Metoprolol represses PGC1α-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart

European Journal of Pharmacology

Volumn 607, Issue 1-3, 2009, Pages 156-166

  Sharma, Vijay ^a   Dhillon, Pavan ^a   Parsons, Hannah ^b   Allard, Michael F ^b   McNeill, John H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

Author keywords

Diabetic cardiomyopathy; Metoprolol; Peroxisome proliferator activated receptor ; PPAR coactivator 1 ; Upstream stimulatory factor

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1B; METOPROLOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG; UPSTREAM STIMULATORY FACTOR 1; UPSTREAM STIMULATORY FACTOR 2; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ISOPROTEIN; MADS DOMAIN PROTEIN; MEF2A PROTEIN, RAT; MYOGENIC FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR; UPSTREAM STIMULATORY FACTOR; USF2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENZYME REPRESSION; IMMUNOPRECIPITATION; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; WISTAR RAT; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; HEART; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; TIME;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; HEART; IMMUNOPRECIPITATION; MADS DOMAIN PROTEINS; MALE; METOPROLOL; MYOGENIC REGULATORY FACTORS; PPAR ALPHA; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; RATS; RATS, WISTAR; TIME FACTORS; TRANSCRIPTION FACTORS; UPSTREAM STIMULATORY FACTORS;

EID: 62149138421     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.02.016     Document Type: Article

References (23)

1. Bonnefont J.P., Djouadi F., Prip-Buus C., Gobin S., Munnich A., and Bastin J. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol. Aspects Med. 25 (2004) 495-520
2. Brandt J.M., Djouadi F., and Kelly D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 273 (1998) 23786-23792
3. Cotter M.A., Cameron N.E., and Robertson S. Polyol pathway-mediated changes in cardiac muscle contractile properties: studies in streptozotocin-diabetic and galactose-fed rats. Exp. Physiol. 77 (1992) 829-838
4. Esser V., Brown N.F., Cowan A.T., Foster D.W., and McGarry J.D. Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes. J. Biol. Chem. 271 (1996) 6972-6977
5. Finck B.N., Han X., Courtois M., Aimond F., Nerbonne J.M., Kovacs A., Gross R.W., and Kelly D.P. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1226-1231
6. Hoit B.D., Castro C., Bultron G., Knight S., and Matlib M.A. Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats. J. Card. Fail. 5 (1999) 324-333
7. Kewalramani G., An D., Kim M.S., Ghosh S., Qi D., Abrahani A., Pulinilkunnil T., Sharma V., Wambolt R.B., Allard M.F., Innis S.M., and Rodrigues B. AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes. J. Mol. Cell. Cardiol. 42 (2007) 333-342
8. Lehman T.C., Hale D.E., Bhala A., and Thorpe C. An acyl-coenzyme A dehydrogenase assay utilizing the ferricenium ion. Anal. Biochem. 186 (1990) 280-284
9. Lydell C.P., Chan A., Wambolt R.B., Sambandam N., Parsons H., Bondy G.P., Rodrigues B., Popov K.M., Harris R.A., Brownsey R.W., and Allard M.F. Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts. Cardiovasc. Res. 53 (2002) 841-851
10. Malone J.I., Schocken D.D., Morrison A.D., and Gilbert-Barness E. Diabetic cardiomyopathy and carnitine deficiency. J. Diabetes Complicat. 13 (1999) 86-90
11. Mascaro C., Acosta E., Ortiz J.A., Marrero P.F., Hegardt F.G., and Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J. Biol. Chem. 273 (1998) 8560-8563
12. McGarry J.D., and Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244 (1997) 1-14
13. McGarry J.D., Mills S.E., Long C.S., and Foster D.W. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat. Biochem. J. 214 (1983) 21-28
14. Moore M.L., Park E.A., and McMillin J.B. Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1. J. Biol. Chem. 278 (2003) 17263-17268
15. Ojamaa K., Samarel A.M., and Klein I. Identification of a contractile-responsive element in the cardiac alpha-myosin heavy chain gene. J. Biol. Chem. 270 (1995) 31276-31281
16. Qin W., Khuchua Z., Klein S.C., and Strauss A.W. Elements regulating cardiomyocyte expression of the human sarcomeric mitochondrial creatine kinase gene in transgenic mice. J. Biol. Chem. 272 (1997) 25210-25216
17. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
18. Rodrigues B., Cam M.C., Kong J., Goyal R.K., and McNeill J.H. Strain differences in susceptibility to streptozotocin-induced diabetes: effects on hypertriglyceridemia and cardiomyopathy. Cardiovasc. Res. 34 (1997) 199-205
19. Sawadogo M., and Roeder R.G. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43 (1985) 165-175
20. Sharma V., Dhillon P., Wambolt R., Parsons H., Brownsey R., Allard M.F., and McNeill J.H. Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin (STZ) diabetic rat. Am. J. Physiol.: Heart Circ. Physiol. 294 (2008) H1609-H1620
21. Srere P.A. Citrate synthase. Methods Enzymol. 13 (1969) 3-26
22. van der Leij F.R., Cox K.B., Jackson V.N., Huijkman N.C., Bartelds B., Kuipers J.R., Dijkhuizen T., Terpstra P., Wood P.A., Zammit V.A., and Price N.T. Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals. J. Biol. Chem. 277 (2002) 26994-27005
23. Wang G.L., Moore M.L., and McMillin J.B. A region in the first exon/intron of rat carnitine palmitoyltransferase Ibeta is involved in enhancement of basal transcription. Biochem. J. 362 (2002) 609-618