Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA

Nature Biotechnology

Volumn 27, Issue 3, 2009, Pages 288-292

  Lam, Bianca J ^a   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; AUTOCATALYTIC; CATALYTIC DOMAINS; COGNATE LIGANDS; CONCENTRATION OF; CONSTANT TEMPERATURES; ENVIRONMENTAL MONITORING; EXPONENTIAL GROWTH RATES; LIGAND-BINDING DOMAINS; MEDICAL DIAGNOSTICS; QUANTITATIVE PCR; RNA CATALYSIS; RNA MOLECULES; SMALL MOLECULES;

AMPLIFICATION; CATALYSTS; ENZYMES; NUCLEIC ACIDS; OLIGONUCLEOTIDES; RNA;

LIGANDS;

APTAMER; APTAZYME; LIGAND; RNA LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME SYNTHESIS; GENE AMPLIFICATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA BINDING; RNA REPLICATION;

APTAMERS, NUCLEOTIDE; BIOCATALYSIS; KINETICS; LIGANDS; NUCLEIC ACID CONFORMATION; POLYNUCLEOTIDE LIGASES; RNA; RNA LIGASE (ATP); RNA, CATALYTIC;

EID: 62149112116     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1528     Document Type: Article

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