Perfusion computed tomographic assessment of early hepatocellular carcinoma in cirrhotic liver disease: Initial observations

Journal of Computer Assisted Tomography

Volumn 32, Issue 6, 2008, Pages 855-858

  Ippolito, Davide ^a,b   Sironi, Sandro ^a,b   Pozzi, Massimo ^b   Antolini, Laura ^a,b   Ratti, Laura ^b   Meloni, Franca ^c   Invernizzi, Francesca ^a,b   Valsecchi, Maria Grazia ^a,b   Fazio, Ferruccio ^a,d,e  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b H SGerardo Monza   (Italy)

^c H Vimercate   (Italy)

^d INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

CT perfusion; Functional CT; Hepatocellular carcinoma; Neoangiogenesis

Indexed keywords

COMPUTERIZED TOMOGRAPHY; NONINVASIVE MEDICAL PROCEDURES;

BLOOD VOLUMES; CLASS A; COMPUTED TOMOGRAPHIC; COMPUTED TOMOGRAPHY PERFUSION; FUNCTIONAL COMPUTED TOMOGRAPHY; HEPATOCELLULAR CARCINOMA; LIVER DISEASE; NEOANGIOGENESIS; TIME TO PEAK; TUMOR VASCULARITY;

TUMORS;

ADULT; AGED; ARTERY PERFUSION; ARTICLE; BLOOD VOLUME; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; EARLY CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER PERFUSION; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; NON INVASIVE MEASUREMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; TUMOR VASCULARIZATION; LIVER TUMOR; METHODOLOGY; MIDDLE AGED; PERFUSION; PILOT STUDY; PRECANCER; RADIOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PERFUSION; PILOT PROJECTS; PRECANCEROUS CONDITIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 62149097991     PISSN: 03638715     EISSN: None     Source Type: Journal    
DOI: 10.1097/RCT.0b013e318161dc58     Document Type: Article

References (19)

1. Itai Y, Matsui O. Blood flow and liver imaging. Radiology. 1997;202: 306-314.
2. Matsui O, Kadoya M, Kameyama T, et al. Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology. 1991;178:493-497.
3. Park YN, Yang CP, Fernandez GJ, et al. Neoangio-genesis and sinusoidal capillarization in dysplastic nodules of the liver. Am J Surg Pathol. 1998;22:656-662.
4. Pluda JM. Tumor-associated angiogenesis: mechanisms, clinical applications and therapeutic strategies. Semin Oncol. 1997;24:203-218.
5. Pandharipande PV, Krinsky GA, Rusinek H, et al. Perfusion imaging of the liver: current challenges and future goals. Radiology. 2005;234: 661-673.
6. Miles KA, Griffiths MR. Perfusion CT: a worthwhile enhancement? Br J Radiol. 2003;76:220-231.
7. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT. Radiology. 1993;188:405-411.
8. Miles KA. Perfusion CT for the assessment of tumour vascularity: which protocol? Br J Radiol. 2003;76:36-42.
9. Miles KA. Measurement of tissue perfusion by dynamic computed tomography. Br J Radiol. 1991;64:409-412.
10. Cuenod CA, Leconte I, Siauve N, et al. Deconvolution technique for measuring tissue perfusion by dynamic CT: application to normal and metastatic liver. Acad Radiol. 2002;9:205-211.
11. Van Beers BE, Leconte I, Materne R, et al. Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity. AJR Am J Roentgenol. 2001;176:667-673.
12. Hollander M, Wolfe DA. Nonparametric Statistical Methods. 2nd ed. New York: John Wiley and Sons; 1999.
13. Tsushima Y, Funabasama S, Aoki J. Quantitative perfusion map of malignant liver tumors created from dynamic computed tomography data. Acad Radiol. 2004;11:215-223.
14. Kim CK, Lim JH, Park CK, et al. Neoangiogenesis and sinusoidal capillarization in hepatocellular carcinoma: correlation between dynamic CT and density of tumor microvessels. Radiology. 2005;237:529-534.
15. Fournier LS, Cuenod CA, de Bazelaire C, et al. Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol. 2004;14:2125-2133.
16. Sahani DV, Holalkere NS, Mueller PR, et al. Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue - initial experience. Radiology. 2007;243:736-743.
17. Kan Z, Kobayashi S, Phongkitkarun S, et al. Functional CT quantification of tumor perfusion after transhepatic arterial embolization in a rat model. Radiology. 2005;1:144-150.
18. Kan Z, Phongkitkarun S, Kobayashi S, et al. Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology. 2005;237:151-158.
19. Boone JM. Multidetector CT: opportunities, challenges, and concerns associated with scanners with 64 or more detector rows. Radiology. 2006;241:334-337.