Duodenal epithelioid gastrointestinal stromal tumor with prominent granular cell features

Human Pathology

Volumn 40, Issue 4, 2009, Pages 599-602

  Adamiak, Anna ^a   Lee, Cheng Han ^a   Nielsen, Torsten O ^a   Webber, Douglas ^a   O'Connell, John X ^b  

^a VANCOUVER GENERAL HOSPITAL   (Canada)

^b SURREY MEMORIAL HOSPITAL   (Canada)

Author keywords

DOG1; GIST; KIT; PKC theta

Indexed keywords

ABDOMEN; ADRENAL CORTEX CARCINOMA; ADULT; ARTICLE; CANCER LOCALIZATION; CASE REPORT; CELL STRUCTURE; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DUODENUM; DUODENUM TUMOR; EPITHELIOID CELL; GASTROINTESTINAL STROMAL TUMOR; GASTROINTESTINAL TRACT; GRANULAR CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MALE; PELVIS; PERITONEAL CAVITY; SEQUENCE ANALYSIS;

ADENOMA; DUODENAL NEOPLASMS; DUODENAL ULCER; EPITHELIOID CELLS; GASTROINTESTINAL STROMAL TUMORS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; NEOPLASMS, MULTIPLE PRIMARY; PITUITARY NEOPLASMS; PROTO-ONCOGENE PROTEINS C-KIT; TUMOR MARKERS, BIOLOGICAL;

EID: 62049085235     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2008.09.017     Document Type: Article

References (14)

1. Hirota S., Isozaki K., Moriyama Y., et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science (New York, NY) 279 (1998) 577-580
2. Miettinen M., and Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 130 (2006) 1466-1478
3. Rubin B.P. Gastrointestinal stromal tumours: an update. Histopathology 48 (2006) 83-96
4. Kirsch R., Gao Z.H., and Riddell R. Gastrointestinal stromal tumors: diagnostic challenges and practical approach to differential diagnosis. Adv Anat Pathol 14 (2007) 261-285
5. Espinosa I., Lee C.H., Kim M.K., et al. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol 32 (2008) 210-218
6. Motegi A., Sakurai S., Nakayama H., Sano T., Oyama T., and Nakajima T. PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors. Pathol Int 55 (2005) 106-112
7. West R.B., Corless C.L., Chen X., et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 165 (2004) 107-113
8. Dematteo R.P., Heinrich M.C., El-Rifai W.M., and Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol 33 (2002) 466-477
9. Lux M.L., Rubin B.P., Biase T.L., et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 156 (2000) 791-795
10. Demetri G.D., Benjamin R.S., Blanke C.D., et al. NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)-update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw 5 Suppl 2 (2007) S1-S29 [quiz S30]
11. Miettinen M., Makhlouf H., Sobin L.H., and Lasota J. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol 30 (2006) 477-489
12. Miettinen M., Kopczynski J., Makhlouf H.R., et al. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases. Am J Surg Pathol 27 (2003) 625-641
13. Yantiss R.K., Rosenberg A.E., Selig M.K., and Nielsen G.P. Gastrointestinal stromal tumors: an ultrastructural study. Intern J Surg Pathol 10 (2002) 101-113
14. Heinrich M.C., Corless C.L., Demetri G.D., et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21 (2003) 4342-4349