Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

Tetrahedron

Volumn 65, Issue 16, 2009, Pages 3292-3304

  Brandt, Thomas A ^a   Caron, Stéphane ^a   Damon, David B ^a   DiBrino, Joseph ^a   Ghosh, Arun ^a   Griffith, David A ^a   Kedia, Sandeep ^a   Ragan, John A ^a   Rose, Peter R ^a   Vanderplas, Brian C ^a   Wei, Lulin ^a  

^a PFIZER INC   (United States)

Author keywords

1,3,5 Triazine; CB1 antagonist; Obesity; Pyrazolotriazine; Suzuki coupling; Thiosemicarbazide

Indexed keywords

ANTIOBESITY AGENT; BENZENESULFONIC ACID DERIVATIVE; CANNABINOID 1 RECEPTOR ANTAGONIST; CE 178253; KETONE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; THIOSEMICARBAZIDE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; CHLORINATION; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SUZUKI REACTION;

EID: 62049083037     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.10.067     Document Type: Article

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