Protease-activated receptor (PAR)1 alters bioelectric properties of distal lung epithelia without compromising barrier function

Experimental Lung Research

Volumn 35, Issue 2, 2009, Pages 136-154

  Moraes, Theo J ^a,b   Rafii, Bijan ^b   Niessen, Frank ^c   Suzuki, Tomoko ^d,e   Martin, Raiza ^d,e   Vachon, Eric ^d,e   Vogel, Wolfgang ^a   Ruf, Wolfram ^c   O'Brodovich, Hugh ^a,b   Downey, Gregory P ^d,e,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f DEPARTMENT OF MEDICINE   (United States)

Author keywords

Epithelial permeability; Inflammation; Lung injury; Neutrophil; Proteinase

Indexed keywords

CHLORIDE CHANNEL; PROTEINASE ACTIVATED RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; IN VIVO STUDY; ION TRANSPORT; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; CELL POLARITY; CELLS, CULTURED; CHLORIDE CHANNELS; ELECTRIC IMPEDANCE; EPITHELIUM; ION TRANSPORT; LUNG; MICE; PERMEABILITY; RATS; RATS, WISTAR; RECEPTOR, PAR-1;

EID: 61949412824     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140802490723     Document Type: Article

References (44)

1. Lesur O, et al: Acute respiratory distress syndrome: 30 years later. Can Respir J. 1999;6:71-86.
2. Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med, 2000;342:1334-1349.
3. Bachofen M, E.R. Weibel: Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med. 1982;3:35-56.
4. Lee WL, Downey GP: Leukocyte elastase: physiological functions and role in acute lung injury. Am J Respir Crit Care Med. 2001;164:896-904.
5. Lee WL, Downey GP: Neutrophil activation and acute lung injury. Curr Opin Crit Care. 2001;7:1-7.
6. Moraes TJ, Chow CW, Downey GP: Proteases and lung injury. Crit Care Med. 2003;31(4 Suppl):S189-S194.
7. Cocks TM, Moffatt JD: Protease-activated receptor-2 (PAR2) in the airways. Pulm Pharmacol Ther. 2001;14:183-191.
8. Lan RS, Stewart GA, Henry PJ: Role of protease-activated receptors in airway function: a target for therapeutic intervention? Pharmacol Ther. 2002;95:239-257.
9. Riewald M, Ruf W: Science review: role of coagulation protease cascades in sepsis. Crit Care. 2003;7:123-129.
10. de Garavilla L, et al: Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001;133:975-987.
11. Vergnolle N, et al: Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol. 1999;127:1083-1090.
12. Vergnolle N, Hollenberg MD, Wallace, JL: Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). Br J Pharmacol. 1999;126:1262-1268.
13. Vogel, S.M., et al: Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics. 2000;4:137-145.
14. Berthiaume Y, Folkesson HG, Matthay MA: Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol. 2002;93:2207-2213.
15. O'Brodovich H, Rafii B, Post M: Bioelectric properties of fetal alveolar epithelial monolayers. Am J Physiol. 1990;258(4 Pt 1):L201-L206.
16. Rafii B, et al: Pulmonary oedema fluid induces non-alpha-ENaC-dependent Na(+) transport and fluid absorption in the distal lung. J Physiol. 2002;544(Pt 2):537-548.
17. Pitkanen OM, Tanswell AK, O'Brodovich HM: Fetal lung cell-derived matrix alters distal lung epithelial ion transport. Am J Physiol. 1995;268(5 Pt 1):L762-L771.
18. Ko KS, et al: Cell-cell adhesion in human fibroblasts requires calcium signaling. J Cell Sci. 2001;114(Pt 6):1155-1167.
19. Suzuki T, et al: Proteinase activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005;33:231-247.
20. Avivi-Green C, Singal M, Vogel WF: Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med. 2006;174:420-427.
21. Steinhoff M, et al: Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev. 2005;26:1-43.
22. Balda, MS, Matter K, Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol. 2003;13:310-318.
23. D'Atri F, Citi S: Molecular complexity of vertebrate tight junctions [review]. Mol Membr Biol. 2002;19:103-112.
24. Nagafuchi A: Molecular architecture of adherens junctions. Curr Opin Cell Biol. 2001;13:600-603.
25. Cavanaugh KJ Jr, Oswari J, Margulies SS: Role of stretch on tight junction structure in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2001;25:584-591.
26. Hermiston ML, Gordon JI: Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science. 1995;270:1203-1207.
27. Trepat X, et al: Thrombin and histamine induce stiffening of alveolar epithelial cells. J Appl Physiol. 2005;98:1567-1574.
28. Kawkitinarong K, et al: Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol. 2004;31:517-527.
29. Hermanns MI, et al: Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Lab Invest. 2004;84:736-752.
30. Bertog, M, et al: Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. J Physiol. 1999;521(Pt 1):3-17.
31. Cuffe JE, et al: Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon. J Physiol. 2002;539(Pt 1):209-222.
32. Mall M, et al: Activation of ion secretion via proteinase-activated receptor-2 in human colon. Am J Physiol Gastrointest Liver Physiol. 2002;282:G200-G210.
33. Nguyen TD, et al: Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest. 1999;103(2):261-269.
34. Okafor MC, Dean WL, Delamere NA: Thrombin inhibits active sodium-potassium transport in porcine lens. Invest Ophthalmol Vis Sci. 1999;40:2033-2038.
35. Vergnolle N, et al: Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci USA. 1998;95:7766-7771.
36. Danahay H, et al: Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells. Am J Physiol Cell Physiol. 2001:280:C1455-C1464.
37. Kunzelmann K, et al: Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. Cell Biochem Biophys. 2002;36:209-214.
38. Jenkins RG, et al: Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrindependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006;116:1606-1614.
39. Moffatt JD, Lever R, Page CP: Effects of inhaled thrombin receptor agonists in mice. Br J Pharmacol. 2004;143:269-275.
40. Su X, et al: Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005;175:2598-2605.
41. Riewald M, Ruf W: Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005;280:19808-19814.
42. Feistritzer C, Riewald M: Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood. 2005;105:3178-3184.
43. Nakanishi-Matsui M, et al: PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000;404:609-613.
44. Kaneider NC, et al: 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol. 2007;8:1303-1312.