Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways

Cell Biochemistry and Biophysics

Volumn 36, Issue 2-3, 2002, Pages 209-214

  Kunzelmann, Karl ^a   Schreiber, Rainer ^a   König, Jens ^a   Mall, Marcus ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Airways; CFTR; Colon; Electrolyte transport; Inflammation; PAR2; Protease activated receptor type 2; Trypsin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CHLORIDE; CYCLOPIAZONIC ACID; ENZYME INHIBITOR; INDOLE DERIVATIVE; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN RECEPTOR; TRYPSIN;

ANIMAL; COLON; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; INTESTINE MUCOSA; ION TRANSPORT; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CHLORIDES; COLON; ENZYME INHIBITORS; HUMANS; INDOLES; INTESTINAL MUCOSA; ION TRANSPORT; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; RESPIRATORY MUCOSA; TRYPSIN;

EID: 0036357203     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:36:2-3:209     Document Type: Review

References (14)

1. Dery, O., Corvera, C. U., Steinhoff, M., and Bunnett, N. W. (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 274, C1429-C1452.
2. Lindner, J. R., Kahn, M. L., Coughlin, S. R., Sambrano, G. R., Schauble, E., Bernstein, D., et al. (2000) Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J. Immunol. 165, 6504-6510.
3. Nystedt, S., Emilsson, K., Wahlestedt, C., and Sundelin, J. (1994) Molecular cloning of a potential proteinase activated receptor. Proc. Natl. Acad. Sci. USA 91, 9208-9212.
4. Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., et al. (1996) NA, Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314, 1009-1016.
5. D'Andrea, M. R., Derian, C. K., Leturcq, D., Baker, S. M., Brunmark, A., Ling, P., et al. (1998) Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J. Histochem. Cytochem. 46, 157-164.
6. Cocks, T. M., Fong, B., Chow, J. M., Anderson, G. P., Frauman, A. G., Goldie, R. G., et al. (1999). A protective role for protease-activated receptors in the airways. Nature 398, 156-160.
7. Nguyen, T. D., Moody, M. W., Steinhoff, M., Okolo, C., Koh, D. S., and Bunnett, N. W. (1999) Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J. Clin. Invest. 103, 261-269.
8. Kong, W., McConalogue, K., Khitin, L. M., Hollenberg, M. D., Payan, D. G., Bohm, S. K., et al. (1997) Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc. Natl. Acad. Sci. USA 94, 8884-8889.
9. Vergnolle, N., Macnaughton, W. K., Al-Ani, B., Saifeddine, M., Wallace, J. L., and Hollenberg, M. D. (2000) Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc. Natl. Acad. Sci. USA 95, 7766-7771.
10. Chow, J. M., Moffatt, J. D., and Cocks, T. M. Effect of protease-activated receptor (PAR)-1, -2 and -4-activating peptides, thrombin and trypsin in rat isolated airways. Br. J. Pharmacol. 131, 1584-1591.
11. Buresi, M. C., Schleihauf, E., Vergnolle, N., Buret, A., Wallace, J. L., Hollenberg, M. D., et al. (2001) Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells. Am. J. Physiol. 281, G323-G332.
12. Levo, Y. and Livni, N. (1978) Mast-cell degranulation in Crohn's disease. Lancet 1, 1262.
13. Rao, S. N. (1973) Mast cells as a component of the granuloma in Crohn's disease. J. Pathol. 109, 79-82.
14. Crowe, S. E., Luthra, G. K., and Perdue, M. H. (1997) Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease. Gut 41, 785-792.