TLR-mediated immune activation in HIV

Blood

Volumn 113, Issue 2, 2009, Pages 269-270

  Chang, J Judy ^a   Altfeld, Marcus ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; GASTROINTESTINAL TRACT; GENETIC POLYMORPHISM; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; IMMUNE SYSTEM; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; INNATE IMMUNITY; LYMPH FOLLICLE; LYMPHOCYTE DEPLETION; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 61949158436     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-10-184598     Document Type: Note

References (8)

1. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371.
2. MeierA,Alter G,FrahmN,etal. MyD88-dependent immune activation mediated byhuman immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol. 2007;81:8180-8191.
3. Beignon AS, McKennaK,SkoberneM,etal. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest. 2005;115:3265-3275.
4. Heikenwalder M,PolymenidouM,Junt T, etal. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004;10:187-192.
5. Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526-1529.
6. Mandl JN, Barry AP, Vanderford TH, et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat Med. 2008;14:1077-1087.
7. Schott E, Witt H, Neumann K, et al. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol. 2007;47:203-211.
8. Oh DY, Taube S, Hamouda O, et al. A functional tolllike receptor 8 variant is associated with HIV disease restriction. J Infect Dis. 2008;198:701-709.