Effects of exercise on energy-regulating hormones and appetite in men and women

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 2, 2009, Pages

  Hagobian, Todd A ^a   Sharoff, Carrie G ^a   Stephens, Brooke R ^a   Wade, George N ^a   Silva, J Enrique ^b   Chipkin, Stuart R ^a   Braun, Barry ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b BAYSTATE MEDICAL CENTER   (United States)

Author keywords

Acylated ghrelin; Body fat; Food intake; Insulin; Leptin; Physical activity

Indexed keywords

GHRELIN; INSULIN; LEPTIN; GHRL PROTEIN, HUMAN; HORMONE; THYROID HORMONE;

ACYLATION; ADULT; APPETITE; AREA UNDER THE CURVE; ARTICLE; BODY FAT; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; EXERCISE; FEMALE; FOOD INTAKE; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; MALE; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEX DIFFERENCE; SEX RATIO; SITTING; STATISTICAL SIGNIFICANCE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DIET; ENERGY METABOLISM; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; RISK REDUCTION; TIME;

ADULT; APPETITE REGULATION; CROSS-OVER STUDIES; DIET; ENERGY INTAKE; ENERGY METABOLISM; EXERCISE; FEMALE; GHRELIN; HORMONES; HUMANS; INSULIN; LEPTIN; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; RISK REDUCTION BEHAVIOR; SEX FACTORS; THYROID HORMONES; TIME FACTORS; YOUNG ADULT;

EID: 61949092866     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90671.2008     Document Type: Article

References (49)

1. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337-345, 2001. (Pubitemid 32149296)
2. Berriman SJ, Wade GN, Blaustein JD. Expression of Fos-like proteins in gonadotropin-releasing hormone neurons of Syrian hamsters: effects of estrous cycles and metabolic fuels. Endocrinology 131: 2222-2228, 1992.
3. Black SE, Mitchell E, Freedson PS, Chipkin SR, Braun B. Improved insulin action following short-term exercise training: role of energy and carbohydrate balance. J Appl Physiol 99: 2285-2293, 2005. (Pubitemid 41691649)
4. Brooks GA, Butte NF, Rand WM, Flatt JP, Caballero B. Chronicle of the Institute of Medicine physical activity recommendation: how a physical activity recommendation came to be among dietary recommendations. Am J Clin Nutr 79: 921S-930S, 2004.
5. Broom DR, Stensel DJ, Bishop NC, Burns SF, Miyashita M. Exercise-induced suppression of acylated ghrelin in humans. J Appl Physiol 102: 2165-2171, 2007. (Pubitemid 47080747)
6. Clegg DJ, Brown LM, Woods SC, Benoit SC. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55: 978-987, 2006.
7. Dafopoulos K, Sourlas D, Kallitsaris A, Pournaras S, Messinis IE. Blood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle. Fertil Steril In press.
8. Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K. International Union of Pharmacology. LVI Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev 57: 541-546, 2005. (Pubitemid 43036440)
9. Despres JP, Bouchard C, Savard R, Tremblay A, Marcotte M, Theriault G. The effect of a 20-week endurance training program on adiposetissue morphology and lipolysis in men and women. Metab Clin Exp 33: 235-239, 1984. (Pubitemid 14151223)
10. Dickerman RW, Li HY, Wade GN. Decreased availability of metabolic fuels suppresses estrous behavior in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol 264: R568-R572, 1993.
11. Donnelly JE, Hill JO, Jacobsen DJ, Potteiger J, Sullivan DK, Johnson SL, Heelan K, Hise M, Fennessey PV, Sonko B, Sharp T, Jakicic JM, Blair SN, Tran ZV, Mayo M, Gibson C, Washburn RA. Effects of a 16-month randomized controlled exercise trial on body weight and composition in young, overweight men and women: the Midwest Exercise Trial. Arch Intern Med 163: 1343-1350, 2003. (Pubitemid 36676200)
12. Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 83: 1407-1413, 1998.
13. Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, STS, Cummings D. Human plasma ghrelin levels increase during a one-year exercise program. J Clin Endocrinol Metab 90: 820-825, 2005. (Pubitemid 40279203)
14. Freedson PS, Melanson E, Sirard J. Calibration of the Computer Science and Applications, Inc. accelerometer. Med Sci Sports Exerc 30: 777-781, 1998. (Pubitemid 28211005)
15. Gayle DA, Desai M, Casillas E, Beloosesky R, Ross MG. Gender-specific orexigenic and anorexigenic mechanisms in rats. Life Sci 79: 1531-1536, 2006. (Pubitemid 44301268)
16. Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G. Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol(Oxf) 62: 1-17, 2005. (Pubitemid 40175277)
17. Hagobian TA, Braun B. Interactions between energy surplus and shortterm exercise on glucose and insulin responses in healthy people with induced, mild insulin insensitivity. Metabolism 55: 402-408, 2006. (Pubitemid 43234396)
18. Hagobian TA, Sharoff CG, Braun B. Effects of short-term exercise and energy surplus on hormones related to regulation of energy balance. Metabolism 57: 393-398, 2008.
19. Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Luke-Zeitoun M, Brooks GA. Glucoregulation is more precise in women than in men during postexercise recovery. Am J Clin Nutr 87: 1686-1694, 2008.
20. Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Mau TL, Luke-Zeitoun M, Brooks GA. Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period. J Physiol 584: 963-981, 2007. (Pubitemid 350031935)
21. Hickey MS, Houmard JA, Considine RV, Tyndall GL, Midgette JB, Gavigan KE, Weidner ML, McCammon MR, Israel RG, Caro JF. Gender-dependent effects of exercise training on serum leptin levels in humans. Am J Physiol Endocrinol Metab 272: E562-E566, 1997.
22. Hill JO, Sparling PB, Shields TW, Heller PA. Effects of exercise and food restriction on body composition and metabolic rate in obese women. Am J Clin Nutr 46: 622-630, 1987.
23. Hilton LK, Loucks AB. Low energy availability, not stress, suppresses diurnal rhythm of leptin in healthy young women. Am J Physiol Endocrinol Metab 278: E43-E49, 2000.
24. Kien CL, Ugrasbul F. Prediction of daily energy expenditure during a feeding trial using measurements of resting energy expenditure, fat-free mass, or Harris-Benedict equations. Am J Clin Nutr 80: 876-880, 2004. (Pubitemid 41202085)
25. Klem ML, Wing RR, McGuire MT, Seagle HM, Hill JO. A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am J Clin Nutr 66: 239-246, 1997.
26. Klesges RC, Eck LH, Ray JW. Who underreports dietary intake in a dietary recall? Evidence from the Second National Health and Nutrition Examination Survey. J Consult Clin Psychol 63: 438-444, 1995.
27. Kyriazis GA, Caplan JD, Lowndes J, Carpenter RL, Dennis KE, Sivo SA, Angelopoulos TJ. Moderate exercise-induced energy expenditure does not alter leptin levels in sedentary obese men. Clin J Sport Med 17: 49-51, 2007. (Pubitemid 46279924)
28. Leidy HJ, Dougherty KA, Frye BR, Duke KM, Williams NI. Twenty-four- hour ghrelin is elevated after calorie restriction and exercise training in non-obese women. Obesity 15: 446-455, 2007.
29. Leidy HJ, Gardner JK, Frye BR, Snook ML, Schuchert MK, Richard EL, Williams NI. Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J Clin Endocrinol Metab 89: 2659-2664, 2004.
30. Loucks AB, Heath EM. Induction of low-T3 syndrome in exercising women occurs at a threshold of energy availability. Am J Physiol Regul Integr Comp Physiol 266: R817-R823, 1994.
31. Loucks AB, Thuma JR. Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab 88: 297-311, 2003.
32. Martini AC, Fernandez-Fernandez R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 147: 2374-2382, 2006.
33. Morton GJ, Schwartz MW. The NPY/AgRP neuron and energy homeostasis. Int J Obes Relat Metab Disord 25 Suppl 5: S56-S62, 2001.
34. Pober DM, Freedson PS, Kline GM, McInnis KJ, Rippe JM. Development and validation of a one-mile treadmill walk test to predict peak oxygen uptake in healthy adults ages 40 to 79 years. Can J Appl Physiol 27: 575-589, 2002.
35. Poehlman ET, Tremblay A, Nadeau A, Dussault J, Theriault G, Bouchard C. Heredity and changes in hormones and metabolic rates with short-term training. Am J Physiol Endocrinol Metab 250: E711-E717, 1986. (Pubitemid 16060082)
36. Potteiger JA, Jacobsen DJ, Donnelly JE, Hill JO. Glucose and insulin responses following 16 months of exercise training in overweight adults: the Midwest Exercise Trial. Metab Clin Exp 52: 1175-1181, 2003.
37. Ravussin E, Tschop M, Morales S, Bouchard C, Heiman ML. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab 86: 4547-4551, 2001. (Pubitemid 32848587)
38. Romon M, Gomila S, Hincker P, Soudan B, Dallongeville J. Influence of weight loss on plasma ghrelin responses to high-fat and high-carbohydrate test meals in obese women. J Clin Endocrinol Metab 91: 1034-1041, 2006. (Pubitemid 43357777)
39. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R, Janssen I. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 133: 92-103, 2000. (Pubitemid 30490409)
40. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, and Pi-Sunyer FX. Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71: 2402-2411, 1991.
41. Stubbs RJ, Hughes DA, Johnstone AM, Whybrow S, Horgan GW, King N, Blundell J. Rate and extent of compensatory changes in energy intake and expenditure in response to altered exercise and diet composition in humans. Am J Physiol Regul Integr Comp Physiol 286: R350-R358, 2004. (Pubitemid 38140380)
42. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell J. The effect of graded levels of exercise on energy intake and balance in free-living men, consuming their normal diet. Eur J Clin Nutr 56: 129-140, 2002. (Pubitemid 34145155)
43. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, King N, Horgan G, Blundell JE. The effect of graded levels of exercise on energy intake and balance in free-living women. Int J Obes Relat Metab Disord 26: 866-869, 2002. (Pubitemid 34620879)
44. Tannous dit El Khoury, D., Obeid O, Azar ST, Hwalla N. Variations in postprandial ghrelin status following ingestion of high-carbohydrate, highfat, and high-protein meals in males. Ann Nutr Metab 50: 260-269, 2006.
45. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 407: 908-913, 2000.
46. Wade GN, Jones JE. Neuroendocrinology of nutritional infertility. Am J Physiol Regul Integr Comp Physiol 287: R1277-R1296, 2004.
47. Woods SC, Gotoh K, Clegg DJ. Gender differences in the control of energy homeostasis. Exp Biol Med (Maywood) 228: 1175-1180, 2003. (Pubitemid 37413676)
48. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992, 2001.
49. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141: 4325-4328, 2000.