Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec- 3-yl acetic acid ethyl esters as norcantharidin analogues

Letters in Drug Design and Discovery

Volumn 6, Issue 1, 2009, Pages 1-7

  Sauer, Benjamin ^a   Gilbert, Jayne ^b   Sakoff, Jennette A ^b   McCluskey, Adam ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

Author keywords

Anticancer; Drug design scaffold; Norcantharidin; Protein phosphatase 1 and 2A; Wittig reaction

Indexed keywords

(3 HYDROXY 4 MORPHOLIN 4 YL 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (3 HYDROXY 4 OCTYL 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (3 HYDROXY 5 OXO 4 PROPYL 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (4 BUTYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (4 CYCLOHEXYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (4 ETHYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (4 HEXYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (4 SEC BUTYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL)ACETIC ACID ETHYL ESTER; (5 OXO 4,10 DIOXATRICYCLO[5.2.1]DEC 3 YLIDENE)ACETIC ACID ETHYL ESTER; (TRIPHENYLPHOSPHANYLIDENE)ACETIC ACID ETHYL ESTER; 3 HYDROXY 4 (2 MORPHOLIN 4 YLETHYL) 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL]ACETIC ACID ETHYL ESTER; 4 (3 ETHOXYCARBONYLMETHYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 4 YL)BUTYRIC ACID; 6 (3 ETHOXYCARBONYLMETHYL 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 4 YL)HEXANOIC ACID; [3 HYDROXY 4 (3 MORPHOLIN 4 YLPROPYL) 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL]ACETIC ACID ETHYL ESTER; [3 HYDROXY 4 (6 HYDROXYHEXYL) 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL]ACETIC ACID ETHYL ESTER; [4 (2 DIMETHYLAMINOETHYL) 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL]ACETIC ACID ETHYL ESTER; [4 (3 DIMETHYLAMINOPROPYL) 3 HYDROXY 5 OXO 10 OXA 4 AZATRICYCLO[5.2.1]DEC 3 YL]ACETIC ACID ETHYL ESTER; CANTHARIDIN; HERBACEOUS AGENT; NORCANTHARIDIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HERBAL MEDICINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WITTIG REACTION;

EID: 61849142319     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018009787158535     Document Type: Article

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