Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

Letters in Drug Design and Discovery

Volumn 6, Issue 1, 2009, Pages 29-32

  Teus, M ^a   Jirgensons, A ^a,b   Dambrova, M ^a   Mezhapuke, R ^a   Parsons, C G ^c   Danysz, W ^c  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b RIGA TECHNICAL UNIVERSITY   (Latvia)

^c MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

5 hydroxyisoxazole; Glutamate; Glutamate carboxypeptidase II; Lipophilicity; Synthesis

Indexed keywords

ENZYME INHIBITOR; GLUTAMATE CARBOXYPEPTIDASE II; ISOXAZOLE DERIVATIVE; N ACETYLASPARTYLGLUTAMIC ACID;

ARTICLE; BLOOD BRAIN BARRIER; DRUG PENETRATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; PASSIVE TRANSPORT; PRIORITY JOURNAL;

EID: 61849129674     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018009787158544     Document Type: Article

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