Relationship of insulin resistance and related metabolic variables to coronary artery disease: A mathematical analysis

Diabetes Care

Volumn 32, Issue 2, 2009, Pages 361-366

  Eddy, David ^a   Schlessinger, Len ^a   Kahn, Richard ^b   Peskin, Barbara ^a   Schiebinger, Rick ^c  

^a Archimedes Inc   (United States)

^b AMERICAN DIABETES ASSOCIATION   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HEART INFARCTION; HUMAN; INSULIN RESISTANCE; MALE; SMOKING; SYSTOLIC BLOOD PRESSURE; BIOLOGICAL MODEL; CLINICAL TRIAL; COMPUTER SIMULATION; INCIDENCE; NUTRITION; PATHOPHYSIOLOGY; RISK FACTOR; UNITED STATES;

ADULT; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; CORONARY DISEASE; HUMANS; INCIDENCE; INSULIN RESISTANCE; MODELS, CARDIOVASCULAR; MYOCARDIAL INFARCTION; NUTRITION SURVEYS; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 61849120255     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-0854     Document Type: Article

References (25)

1. Reaven GM: Banting lecture 1988: role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
2. Zavaroni I, Bonara E, Pagliara M, Dall'Aglio E, Luchetti L, Buonnano G, Bonati PA, Bergonzani M, Gnudi L, Paseri M: Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320:702-706, 1989
3. Ginsberg HN: Insulin resistance and cardiovascular disease. J Clin Invest 106:453-458, 2000
4. Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G: Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 95: 158-166, 1995
5. Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10, 1997
6. Kelley DE, Mokan M, Simoneau JA, Man- darino LJ: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92:91-98, 1993
7. Steinberg HO, Paradisi G, Hook G, Crow- der K, Cronin J, Baron AD: Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes 49:1231-1238, 2000
8. Juhan-Vague I, Alessi M, Vague P: Increased plasma PAI-1 levels: a possible link between insulin resistance and atherothrombosis. Diabetologia 34:457462, 1991
9. Alessi MC, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I: Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes 46:860-867, 1997
10. Schlessinger L, Eddy DM: Archimedes: a new model for simulating health care systems: the mathematical formulation. J Biomed Inform 35:37-50, 2002
11. Eddy DM, Schlessinger L: Archimedes: a trial-validated model of diabetes. Diabetes Care 26:3093-3101, 2003
12. Eddy DM, Schlessinger L: Validation of the Archimedes diabetes model. Diabetes Care 26:3102-3110, 2003
13. American Diabetes Association Consensus Panel: Guidelines for computer modeling of diabetes and its complications. Diabetes Care 27:2262-2265, 2004
14. UK Prospective Diabetes Study Group: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 310:83-88, 1995
15. Colagiuri S, Cull CA, Holman RR, the UK- PDS Group: Are lower fasting plasma glucose levels at diagnosis of type 2 diabetes associated with improved outcomes? Diabetes Care 25:1410-1417, 2002
16. Cowie CC, Harris MI: Physical and metabolic characteristics of persons with diabetes. In Diabetes in America. 2nd ed. Harris MI, Cowie CC, Stern MP, Eds. Washington, DC, U.S. Govt. Printing Office, 1995 (NIH publ. no. 95-1468)
17. Ross D, Cabal A, Schlessinger L, Bethel J, Bowman J, Firouzian M, Dudl J, Eddy D: To what extent are insulin resistance and related metabolic variables responsible for coronary artery disease? Variables review [article online], 2008. Available from http://archimedesmodel.com/pdf/Metabolic-Variables-8-26-08. pdf. Accessed 26 August 2008
18. National Center for Health Statistics: National Health and Nutrition Examination Survey [Internet]. Available from http://www.cdc.gov/nchs/nhanes. htm. Accessed 9 January 2008
19. UK Prospective Diabetes Study Group: Effect of intensive blood-glucose control with metformin on complications inover-weight patients with type 2 diabetes (UK- PDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854-865, 1998
20. UK Prospective Diabetes Study Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837-853, 1998
21. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW: 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577-1589, 2008
22. Action to Control Cardiovascular Risk in Diabetes Study Group: Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545-2559, 2008
23. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbe D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F; ADVANCE Collaborative Group: Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358: 2560-2572, 2008
24. McGarryJD: Banting Lecture 2001: dys- regulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51:718, 2002
25. Glund S, Krook A: Role of interleukin-6 signalling in glucose and lipid metabolism. Acta Physiol (Oxf) 192:37-48, 2008