Comparison of statistical power between 2 × 2 allele frequency and allele positivity tables in case-control studies of complex disease genes

Annals of Human Genetics

Volumn 65, Issue 2, 2001, Pages 197-206

  Ohashi, J ^a   Yamamoto, S ^b   Tsuchiya, N ^a   Hatta, Y ^a   Komata, T ^a   Matsushita, M ^a,c   Tokunaga, K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANALYTICAL ERROR; ARTICLE; CASE CONTROL STUDY; COMPARATIVE STUDY; CONTROLLED STUDY; DATA ANALYSIS; GENE FREQUENCY; GENE LOCUS; HYPOTHESIS; INHERITANCE; MARKER GENE; PENETRANCE; PRIORITY JOURNAL; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ALLELES; CASE-CONTROL STUDIES; GENE FREQUENCY; GENES, DOMINANT; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MODELS, GENETIC; PENETRANCE; RESEARCH DESIGN; SAMPLE SIZE; STATISTICS;

EID: 0035024283     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S000348000100851X     Document Type: Article

References (11)

1. Bannai, M., Tokunaga, K., Lin, L., Kuwata, S., Mazda, T., Amaki, I., Fujisawa, K. & Juji, T. (1994). Discrimination of human HLA-DRB1 alleles by PCR-SSCP (single-strand conformation polymorphism) method. Eur. J. Immunogenet. 21, 1-9.
2. Camp, N. J. (1999). Genomewide transmission/disequilibrium testing: a correction. Am. J. Hum. Genet. 64, 1485-1487.
3. Hashimoto, H., Nishimura, Y., Dong, R. P., Kimura, A., Sasazuki, T., Yamanaka, K., Tokano, Y., Murashima, A., Kabasawa, K. & Hirose, S. (1994). HLA antigens in Japanese patients with systemic lupus erythematosus. Scand. J. Rheumatol. 23, 191-196.
4. Hatta, Y., Tsuchiya, N., Ohashi, J., Matsushita, M., Fujiwara, K., Hagiwara, K., Juji. T. & Tokunaga, K. (1999). Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese. Genes and Immunity 1, 53-60.
5. Kawai, S., Maekawajiri, S., Tokunaga, K., Kashiwase, K., Miyamato, M., Akaza, T., Juji, T. & Yamane, A. (1996). Routine low and high resolution typing of the HLA-RRB gene using the PCR-MPH (microtitre plate hybridization) method. Eur. J. Immunogenet. 23, 471-486.
6. Komata, T., Tsuchiya, N., Matsushita, M., Hagiwara, K. & Tokunaga, K. (1999). Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens 53, 527-533.
7. Ohashi, J. & Tokunaga, K. (1999). Selecting a contingency table in a population based association study: allele frequency or positivity? J. Hum. Genet. 44, 246-248.
8. Risch, N. & Merikangas, K. (1996). The future of genetic studies of complex human diseases. Science 273, 1516-1517.
9. Sasieni, P. D. (1997). From genotypes to genes: doubling the sample size. Biometrics 53, 1253-1261.
10. Spielman, R. S., McGinnis, R. E. & Ewens, W. J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516.
11. Tsao, B. P. (1998). Genetic susceptibility to lupus nephritis. Lupus 7, 585-590.