Aceclofenac organogels: In vitro and in vivo characterization

Current Drug Delivery

Volumn 6, Issue 1, 2009, Pages 1-7

  Shaikh, I M ^a   Jadhav, S L ^a   Jadhav, K R ^a   Kadam, V J ^a   Pisal, S S ^b  

^a BHARATI VIDYAPEETH S COLLEGE OF PHARMACY   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Aceclofenac; Ethyl oleate; Lecithin organogel; Topical

Indexed keywords

ACECLOFENAC; EPIKURON 200; OLEIC ACID ETHYL ESTER; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; GEL; HISTOPATHOLOGY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MALE; MICELLE; NONHUMAN; ORGANOGEL; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; VISCOSITY;

ANIMALS; DICLOFENAC; GELS; LECITHINS; LIGHT; MALE; RATS; SCATTERING, RADIATION; SKIN; SOLUBILITY; VISCOSITY;

EID: 61849096275     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720109787048320     Document Type: Article

References (28)

1. Prausnitz, M.R.; Mitragotri, S.; Langer, R. Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Dis., 2004, 3, 115- 24.
2. Nishihata, T.; Kotera, K.; Nakano, Y.; Yamazaki, Y. Rat percutaneous transport of diclofenac and influence of hydrogenated soya phospholipids. Chem. Pharm. Bull., 1987, 35, 3807-12.
3. Yokomizo, Y. Effects of phospholipids on percutaneous penetration of drugs through the dorsal of the guinea pig, in vitro.3.The effects of phospholipids on several drugs having different polarities. J. Control. Release, 1996, 42, 217-28.
4. Yokomiza, Y. Effects of phophatidylcholine on the percutaneous penetration of drugs the dorsal skin of guinea pigs in vitro; and analysis of the molecular mechanism, using attenuated total reflectance-Fourier Transform infrared (ATR-FTIR) spectroscopy. J. Control. Release, 1996, 42, 249-62.
5. Kirjavainen, M.; Monkkonen, J.; Saukkosaari, M.; Valjakkakoskela, R.; Kiesvaara J; Urtti A. Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers. J. Control. Release, 1999, 29, 207-14.
6. Touitou, E.; Dayan, N.; Bergelson, L.; Goo din, B.; Elias, M. Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties J. Control. Release, 2000, 65, 403-18.
7. Vyas, S.P.; Singh, R.; Asati, R.K. Liposomally encapsulated diclofenac for sonophoresis induced systemic delivery J. Microencapsul., 1995, 12, 149-54.
8. Woyczikowski, B.; Szuls, J.; Janicki, S. Effect of the mode of preparation of liposomes on trapping efficiency of sodium diclofenac. Farm-Pol. (Farmaja-polska), 1996, 52, 1011-5.
9. Dayan, N.; Touitou, E. Carriers for skin delivery of trihexyl phenidyl HCl: ethasomes vs liposomes. Biomaterials, 2000, 21, 1879-85.
10. Cevc, G. Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement of vesicle penetration, and transdermal drug delivery. Crit. Rev. Ther. Drug Carrier Syst., 1996, 13, 257-388.
11. Scartazzini, R.; Luisi, P.L.. Organogels from lecithins. J. Phys Chem., 1988, 92, 829-33.
12. Willimann, H.; Walde, P.; Luisi, P.L.; Gazzaniga, A.; Stroppolo, F. Lecithin organogels as matrix for transdermal transport of drugs. J. Pharm. Sci., 1992, 81, 871-4.
13. Dreher, F.; Walde, P.; Walther, P.; Wehrli, E. Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport. J. Control. Release, 1997, 45, 131-40.
14. Agrawal, G.P.; Juneja, M.; Agrawal, S.; Jain, S.K.; Pancholi, S. S. Preparation and characterization of reverse micelle based organogels of piroxicam. Pharmazie, 2004, 59, 191-3.
15. Zia, H.A.; Aboofazeli, R.; Nasseri, A.; Needham, T.E. Lecithin stabilized microemulsion based organogels for topical application of ketorolac tromethamine. II. in vitro release study. Iran. J. Pharmaceut. Res., 2003, 2, 117-24.
16. Yong, C.S.; Oh, Y.K.; Lee, K.H.; Park, S.M; Park, Y.J.; Gil, Y.S.; Yu, C.H.; Yoo, B.K.; . Woo, J.S.; Kim, J.O.; Rhee, J.D.; Kim, C.K.; , Choi, H.G. Trials of clear aceclofenac-loaded soft capsules with accelerated oral absorption in human subjects. Int. J. Pharm., 2005, 302, 78-83 .
17. Luigi, T.; Luciano, C.; Alberto, B.; Giuseppe, L.; Umberto, M.; Luigi, P.; Aldo, P.; Giovanni, T.; Alberto, S.; Gartano, T.; Luigi, S.; Eugenio, M. Aceclofenac cream versus piroxicam cream in the treatment of patients with minor traumas and phlogistic affections of soft tissues: a double-blind study. Curr. Ther. Res., 1995, 56, 702-12.
18. Yang, J.H.; Young, K.; Kim, K.M. Preparation and evaluation of aceclofenac microemulsion for transdermal delivery system. Arch. Pharm. Res., 2002, 25, 534-40.
19. Eccleston, G.M. Microemulsion. In: Encyclopedia of Pharmaceutical Technology. Swarbrick, J; Boylan, J.C.; Eds. New York; Marcel Dekker, 1992, 9, 375-421.
20. Barry, B.W.; Meyer, M.C. The rheological properties of Carbopol gels I. Continuous shear and creep properties of Carbopol gels. Int. J. Pharm., 1979, 2, 1-25.
21. Li, G.L.; Geest, R.V.; Chanet, L.; Zanten, E.V.; Danhof, M., Bouwstra, J.A. In vitro iontophoresis of R-apomorphine across human stratum corneum Structure-transport relationship of penetration enhancement. J. Control. Release, 2002, 84, 49-57.
22. Schurtenberger, P.; Scartazzini, R. ; Luisi, P.L. Viscoelastic properties of polymerlike reverse micelles Rheol. Acta.,1989, 28, 372-81.
23. Natsuki, R.; Takabatake, E. Effect of lecithin on percutaneous absorption of drugs. II. Mechanism of enhancing effect of lecithin on the percutaneous absorption of indomethacin gel-ointment. J. Pharm. Soc. Jpn., 1987, 107, 622-6.
24. Bhatnagar, S.; Vyas, S.P. Organogel-based system for transdermal delivery of propranolol. J. Microencapsul., 1994, 2, 431-8.
25. Shchipunov, YuA. Lecithin organogel: a micellar system with unique properties. Colloids Surf., 2001, 185, 541-54.
26. Kumar, V.V.; Kumar C.; Raghunathan P. Studies on lecithin reverse micelles: Optical birefringence, viscosity, light scattering, electrical conductivity, and electron microscopy. J. Colloidal Int. Sci., 1984, 99, 315-23.
27. Angelico, R.; Ceglie, A.; Colafemmina, G.; Lopez, F.; Murgia, S.; Olsson, U.; Palazzo, G. Biocompatible lecithin organogels: structure and phase equilibria. Langmuir, 2005, 21, 140-8.
28. Hem, S.L.; Bright, D.R.; Banker, G.S.; Pogue, J.P. Tissue irritation evaluation of potential parenteral vehicles. Drug Dev. Commun., 1974, 15, 471-7.