Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1960-1965

  Schweinitz, Andrea ^a   Dönnecke, Daniel ^a   Ludwig, Alexander ^a   Steinmetzer, Peter ^a   Schulze, Alexander ^a   Kotthaus, Joscha ^b   Wein, Silvia ^b   Clement, Bernd ^b   Steinmetzer, Torsten ^c  

^a The Medicines Company (Leipzig) GmbH   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Anticancer drugs; Matriptase; Protease inhibitor; Serine protease

Indexed keywords

3 AMIDINOPHENYLALANINE DERIVATIVE; AMIDINE; BLOOD CLOTTING FACTOR 10A; MATRIPTASE; PHENYLALANINE DERIVATIVE; PLASMIN; PLASMINOGEN ACTIVATOR; PROTEINASE; SULFONE DERIVATIVE; THROMBIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROPHILICITY;

ADMINISTRATION, ORAL; AMIDINES; ANIMALS; FACTOR XA; PHENYLALANINE; RATS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; THROMBIN;

EID: 61849086891     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.047     Document Type: Article

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