Role for α3 integrin in EMT and pulmonary fibrosis

Journal of Clinical Investigation

Volumn 119, Issue 1, 2009, Pages 7-10

  Borok, Zea ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3 INTEGRIN; BETA CATENIN; BLEOMYCIN; COLLAGEN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TYROSINE; WNT PROTEIN; ANTINEOPLASTIC ANTIBIOTIC;

CELL ADHESION; CELL MEMBRANE; CELL NUCLEUS; EPITHELIUM CELL; FIBROSING ALVEOLITIS; LUNG FIBROSIS; MESENCHYME; MYOFIBROBLAST; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL DIFFERENTIATION; CHEMICALLY INDUCED DISORDER; CYTOLOGY; EXTRACELLULAR MATRIX; GENETICS; HUMAN; MESODERM; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BETA CATENIN; BLEOMYCIN; CELL DIFFERENTIATION; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; INTEGRIN ALPHA3; MESODERM; MICE; MICE, KNOCKOUT; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 61749097791     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI38084     Document Type: Note

References (20)

1. American Thoracic Society and European Respiratory Society. 2002. American Thoracic Society/ European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am. J. Respir. Crit. Care Med. 165:277-304.
2. Selman, M., and Pardo, A. 2006. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc. Am. Thorac. Soc. 3:364-372.
3. Willis, B.C., et al. 2005. Induction of epithelialmesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 166:1321-1332.
4. Kim, K.K., et al. 2006. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl. Acad. Sci. U. S. A. 103:13180-13185.
5. Zavadil, J., and Bottinger, E.P. 2005. TGF-beta and epithelial-to- mesenchymal transitions. Oncogene. 24:5764-5774.
6. Iwano, M., et al. 2002. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110:341-350.
7. Nawshad, A., Lagamba, D., Polad, A., and Hay, E.D. 2005. Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs. 179:11-23.
8. Radisky, D.C., et al. 2005. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123-127.
9. Nelson, W.J., and Nusse, R. 2004. Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483-1487.
10. Cadigan, K.M. 2008. Wnt-beta-catenin signaling. Curr. Biol. 18:R943-R947.
11. Lilien, J., and Balsamo, J. 2005. The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr. Opin. Cell Biol. 17:459-465.
12. Masszi, A., et al. 2004. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for betacatenin. Am. J. Pathol. 165:1955-1967.
13. Huber, A.H., Stewart, D.B., Laurents, D.V., Nelson, W.J., and Weis, W.I. 2001. The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. J. Biol. Chem. 276:12301-12309.
14. Roura, S., Miravet, S., Piedra, J., Garcia de Herreros, A., and Dunach, M. 1999. Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J. Biol. Chem. 274:36734-36740.
15. Kim, K., Lu, Z., and Hay, E.D. 2002. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell. Biol. Int. 26:463-476.
16. Selman, M., Pardo, A., and Kaminski, N. 2008. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med. 5:e62.
17. Konigshoff, M., et al. 2008. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE. 3:e2142.
18. Medici, D., Hay, E.D., and Goodenough, D.A. 2006. Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol. Biol. Cell. 17:1871-1879.
19. Chattopadhyay, N., Wang, Z., Ashman, L.K., Brady-Kalnay, S.M., and Kreidberg, J.A. 2003. alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. J. Cell Biol. 163:1351-1362.
20. Kim, K.K., et al. 2009. Epithelial cell a3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J. Clin. Invest. 119:213-224.