The roles of IL-1, IL-6, and TNFα in the feeding responses to endotoxin and influenza virus infection in mice

Brain, Behavior, and Immunity

Volumn 13, Issue 3, 1999, Pages 252-265

  Swiergiel, Artur H ^a   Dunn, Adrian J ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Endotoxin; Feeding; IL 1 receptor antagonist; Influenza virus; Interleukin 1; Interleukin 6; LPS; TNF binding protein; Tumor necrosis factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BINDING PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEEDING; FOOD INTAKE; HYPOPHAGIA; INFLUENZA; MALE; MILK; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; VIRUS INFECTION;

EID: 0032856499     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1006/brbi.1999.0565     Document Type: Article

References (42)

1. Bernstein I. L. Neural mediation of food aversions and anorexia induced by tumor necrosis factor and tumors. Neurosci. Biobehav. Rev. 20:1996;177-181.
2. Bluthé R.-M., Dantzer R., Kelley K. W. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res. 573:1992;318-320.
3. Bocci V. Interleukins: Clinical pharmacokinetics and practical implications. Clin. Pharmacokinet. 21:1991;274-284.
4. Breder C. D., Hazuka C., Ghayur T., Klug C., Huginin M., Yasuda K., Teng M., Saper C. B. Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl Acad. Sci. USA. 91:1994;11393-11397.
5. Bret-Dibat J.-L., Bluthé R.-M., Kent S., Kelley K. W., Dantzer R. Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism. Brain, Behav. Immun. 9:1995;242-246.
6. Cooney R., Iocono J., Maish G., Smith J. S., Ehrlich P. Tumor necrosis factor mediates impaired wound healing in chronic abdominal sepsis. J. Trauma. 42:1997;415-420.
7. Crestani F., Seguy F., Dantzer R. Behavioral effects of peripherally injected interleukin-1: Role of prostaglandins. Brain Res. 542:1991;330-335.
8. Dantzer R., Bluthé R.-M., Kent S., Goodall G. Behavioral effects of cytokines: An insight into mechanisms of sickness behavior. De Souza E. B. Neurobiology of cytokines Part B. 1993;130-150 Academic Press, San Diego.
9. Dawson D. A., Martin D., Hallenbeck J. M. Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat. Neurosci. Lett. 218:1996;41-44.
10. Dinarello C. Role of interleukin-1 in infectious diseases. Immunol. Rev. 127:1992;119-146.
11. Dinarello C. A. Biology of interleukin 1. FASEB J. 2:1988;108-115.
12. Dunn A. J. The role of interleukin-1 and tumor necrosis factor α in the neurochemical and neuroendocrine responses to endotoxin. Brain Res. Bull. 29:1992;807-812.
13. Dunn A. J. Effects of the interleukin-1 (IL-1) receptor antagonist on the IL-1- and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice. Neuroimmunomodulation. 6:1999.
14. Dunn A. J., Antoon M., Chapman Y. Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing factor. Brain Res. Bull. 26:1991;539-542.
15. Dunn A. J., Chapman Y., Antoon M. Endotoxin-induced behavioral changes of mice in the multicompartment chamber are distinct from those of interleukin-1. Neurosci. Res. Commun. 10:1992;63-69.
16. Dunn, A. J, &, Swiergiel, A. H. The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia. [submitted for publication].
17. Givalois L., Dornand J., Mekaouche M., Solier M. D., Bristow A. F., Ixart G., Siaud P., Assenmacher I., Barbanel G. Temporal cascade of plasma level surges in ACTH, and corticosterone, and cytokines in endotoxin-challenged rats. Am. J. Physiol. 267:1994;R164-170.
18. Hart B. L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12:1988;123-137.
19. Hennet T., Ziltener H. J., Frei K., Peterhans E. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J. Immunol. 149:1992;932-939.
20. Kent S., Bluthé R.-M., Kelley K. W., Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 13:1992a;24-28.
21. Kent S., Kelley K. W., Dantzer R. Effects of lipopolysaccharide on food-motivated behavior in the rat are not blocked by an interleukin-1 receptor antagonist. Neurosci. Lett. 145:1992b;83-86.
22. Kimble R. B., Bain S., Pacifici R. The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J. Bone Miner. Res. 12:1997;935-941.
23. Kitzawa R., Kimble R. B., Vannice J. L., Kung V. T., Pacifici R. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J. Clin. Invest. 94:1994;2397-2406.
24. Kozak W., Conn C. A., Kluger M. J. Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice. Am. J. Physiol. 266:1994;R125-135.
25. Kozak W., Zheng H., Conn C. A., Soszynski D., Van Der Ploeg L. H. T., Kluger M. J. Thermal and behavioral effects of lipopolysaccharide and influenza in interleukin-1β-deficient mice. Am. J. Physiol. 38:1995;R969-977.
26. Krueger J. M., Takahashi S., Kapas L., Bredow S., Roky R., Fang J. D., Floyd R., Renegar K. B., Guha-Thakurta N., Novitsky S., Obal F. Cytokines in sleep regulation. Adv. Neuroimmunol. 5:1995;171-188.
27. Langhans W., Savoldelli D., Weingarten S. Comparison of the feeding responses to bacterial lipopolysaccharide and interleukin-1β Physiol. Behav. 53:1993;643-649.
28. Martin D., Near S. L., Bendele A., Russell D. A. Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein. Exp. Neurol. 131:1995;221-228.
29. McCarthy D. O., Kluger M. J., Vander A. J. Suppression of food intake during infections: Is interleukin-1 involved? Am. J. Clin. Nutr. 42:1985;1179-1182.
30. Oldenburg H. S. A., Rogy M. A., Lazarus D. D., Van Zee K. J., Keeler B. B., Chizzonite R. A., Lowry S. F., Moldawer L. L. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur. J. Immunol. 23:1993;1889-1894.
31. Plata-Salamán C. R., Oomura Y., Kai Y. Tumor necrosis factor and interleukin-1β: Suppression of food intake by direct action in the central nervous system. Brain Res. 448:1988;106-114.
32. Spadaro F., Dunn A. J. Intracerebroventricular administration of interleukin-1 to mice alters investigation of stimuli in a novel environment. Brain Behav. Immun. 4:1990;308-322.
33. Stovroff M. C., Fraker D. L., Swedenborg J. A., Norton J. A. Cachectin/tumor necrosis factor: A possible mediator of cancer anorexia in the rat. Cancer Res. 48:1988;4567-4572.
34. Strassmann G., Kambayashi T. Inhibition of experimental cancer cachexia by anti-cytokine and anti-cytokine-receptor therapy. Cytokines Mol. Ther. 1:1995;107-113.
35. Swiergiel A. H., Smagin G. N., Dunn A. J. Influenza virus infection of mice induces anorexia: Comparison with endotoxin and interleukin-1 and the effects of indomethacin. Pharmacol. Biochem. Behav. 57:1997a;389-396.
36. Swiergiel A. H., Smagin G. N., Johnson L. J., Dunn A. J. The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: Effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra). Brain Res. 776:1997b;96-104.
37. Tasaki K., Ruetzler C. A., Ohtsuki T., Martin D., Nawashiro H., Hallenbeck J. M. Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rat. Brain Res. 748:1997;267-270.
38. van der Meer M. J. M., Sweep C. G. J. F., Pesman G. J., Borm G. F., Hermus A. R. M. M. Synergism between IL-1β and TNF-α on the activity of the pituitary-adrenal axis and on food intake of rats. Am. J. Physiol. 268:1995;E551-557.
39. Vink A., Coulie P., Warnier G., Renauld J.-C., Stevens M., Donckers D., Van Snick J. Mouse plasmacytoma growth in vivo: Enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor. J. Exp. Med. 172:1990;997-1000.
40. Wang J. P., Dunn A. J. The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis induced by endotoxin and interleukin-1β Brain Res. 815:1999;337-348.
41. Weingarten H. P. Cytokines and food intake: The relevance of the immune system to the student of ingestive behavior. Neurosci. Biobehav. Rev. 20:1996;163-170.
42. Yang Z.-J., Koseki M., Meguid M. M., Gleason J. R., Debonis D. Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats. Am. J. Physiol. 267:1994;R1056-1064.