Inducible nitric oxide synthase mediates hippocampal caspase-3 activation in pneumococcal meningitis

International Journal of Neuroscience

Volumn 119, Issue 4, 2009, Pages 455-459

  Braun, Johann ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Brain damage; Caspase 3; iNOS; Meningitis; S. pneumoniae

Indexed keywords

CASPASE 3; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE INACTIVATION; HIPPOCAMPUS; INFLAMMATORY INFILTRATE; KNOCKOUT MOUSE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PNEUMOCOCCAL MENINGITIS; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ANIMALS; CASPASE 3; CEREBROSPINAL FLUID; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE SILENCING; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MENINGITIS, PNEUMOCOCCAL; MICE; MICE, KNOCKOUT; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; STREPTOCOCCUS PNEUMONIAE;

EID: 61649112726     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.1080/00207450802479970     Document Type: Article

References (8)

1. Bratasz, A., Kuter, I., Konior, R., Goscinski, I., & Lukiewicz, S. (2004). Nitric oxide as a prognostic marker for neurological diseases. Antioxidants & Redox Signaling, 6, 613-617.
2. Braun, J. S., Hoffmann, O., Schickhaus, M., Freyer, D., Dagand, E., Bermpohl, D., et al. (2007). Pneumolysin causes neuronal cell death through mitochondrial damage. Infection and Immunity, 75, 4245-4254.
3. Braun, J. S., Novak, R., Herzog, K. H., Bodner, S. M., Cleveland, J. L., & Tuomanen, E. I. (1999). Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nature Medicine, 5, 298-302.
4. Braun, J. S., Novak, R., Murray, P. J., Eischen, C. M., Susin, S. A., Kroemer, G., et al. (2001). Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus. Journal of Infectious Diseases, 184, 1300-1309.
5. Hoffmann, O., Zweigner, J., Smith, S. H., Freyer, D., Mahrhofer, C., Dagand, E., et al. (2006). Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infection and Immunity, 74, 5058-5066.
6. Koedel, U., Scheld, W. M., & Pfister, H. W. (2002). Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infectious Diseases, 2, 721-736.
7. Mitchell, L., Smith, S. H., Braun, J. S., Herzog, K. H., Weber, J. R., & Tuomanen, E. I. (2004). Dual phases of apoptosis in pneumococcal meningitis. Journal of Infectious Diseases, 190, 2039-2046.
8. Winkler, F., Koedel, U., Kastenbauer, S., & Pfister, H. W. (2001). Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown. Journal of Infectious Diseases, 183, 1749-1759.