Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 69, Issue 1, 2009, Pages 145-150

  Iwase, Masanori ^a   Uchizono, Yuji ^a   Nohara, Sakae ^a   Sasaki, Nobuhiro ^a   Sonoki, Kazuo ^a   Iida, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Candesartan; Diabetes mellitus; Insulin; Microangiopathy; Microsphere; Olmesartan; Pancreas

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN; GLUCOSE; INSULIN; MICROSPHERE; OLMESARTAN;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; BLOOD FLOWMETRY; BLOOD PRESSURE REGULATION; CHRONIC DRUG ADMINISTRATION; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC MICROANGIOPATHY; DRUG BLOOD LEVEL; DRUG EFFECT; DUODENUM; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTESTINE BLOOD FLOW; MALE; MICROCIRCULATION; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET; PANCREAS PERFUSION; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; TREATMENT DURATION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; DUODENUM; GLUCOSE; IMIDAZOLES; INSULIN; ISLETS OF LANGERHANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; TETRAZOLES;

RATTUS;

EID: 61649111578     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510802449626     Document Type: Conference Paper

References (37)

1. Bonner-Weir SKahn CRWeir GRKing GLJacobson AMMoses AC, Smith RJ, editors. Islets of Langerhans. Morphology and postnatal growth. Joslin's diabetes mellitus, 14th edn. Philadelphia: Lippincott Williams and Wilkins, 2005. pp. 41-52.
2. Jansson L. The regulation of pancreatic islet blood flow. Diabet Metab Rev 1994;10:407-16.
3. Atef N, Ktorza A, Picon L, Penicaud L. Increased islet blood flow in obese rats: role of the autonomic nervous system. Am J Physiol 1992;262:E736-40.
4. Svensson AM, Abdel-Halim SM, Efendic S, Jansson L, Ostenson CG. Pancreatic and islet blood flow in F1-hybrids of the non-insulin-dependent diabetic GK-Wistar rat. Eur J Endocrinol 1994;130:612-16.
5. Iwase M, Sandler S, Carlsson PO, Hellerstrom C, Jansson L. The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production. Eur J Endocrinol 2001;144:169-78.
6. Jansson L, Andersson A, Bodin B, Kallskog O. Pancreatic islet blood flow during euglycaemic, hyperinsulinaemic clamp in anaesthetized rats. Acta Physiol 2007;189:319-24.
7. Jansson L. Effects of the biguanide metformin on splanchnic blood flow in rats: preferential and dose-dependent increase in islet blood flow. Pharmacology 1995;51:43-7.
8. Iwase M, Nakamura U, Uchizono Y, Nohara S, Sasaki N, Sonoki K, et al. Nateglinide, a non-sulfonylurea rapid insulin secretagogue, increases pancreatic islet blood flow in rats. Eur J Pharmacol 2005;518:243-50.
9. Carlsson PO, Berne C, Jansson L. Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats. Diabetologia 1998;41:127-33.
10. Hypertension in Diabetic Study (HDS). Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications. J Hypertens 1993;11:309-17.
11. Ferranninni E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, et al. Insulin resistance in essential hypertension. N Engl J Med 1987;317:350-7.
12. Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 2007;369:201-7.
13. Cooper SA, Whaley-Connell A, Habibi J, Wei Y, Lastra G, Manrique C, et al. Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance. Am J Physiol 2007;293:H2009-23.
14. Leung PS. The physiology of a local renin-angiotensin system in the pancreas. J Physiol 2007;580:31-7.
15. Tikellis C, Cooper ME, Thomas MC. Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes. Inter J Biochem Cell Biol 2006;38:737-51.
16. Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB, Song KH, et al. Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochem Biophys Res Commun 2004;316:114-22.
17. Tikellis C, Wookey PJ, Candido R, Andrikopoulos S, Thomas MC, Cooper ME. Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat. Diabetes 2004;53:989-97.
18. Chu KY, Lau T, Carlsson PO, Leung PS. Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes 2006;55:367-74.
19. Shao J, Iwashita N, Ikeda F, Ogihara T, Uchida T, Shimizu T, et al. Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochem Biophys Res Commun 2006;344:1224-33.
20. Chu KY, Leung PS. Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice. Antioxid Redox Signal 2007;9:869-78.
21. Huang Z, Jansson L, Sjoholm A. Pancreatic islet blood flow is selectively enhanced by captopril, irbesartan and pravastatin, and suppressed by palmitate. Biochem Biophys Res Commun 2006;346:26-32.
22. Huang Z, Jansson L, Sjoholm A. Vasoactive drugs enhance pancreatic islet blood flow, augment insulin secretion and improve glucose tolerance in female rats. Clin Sci 2007;112:69-76.
23. Kansui Y, Fujii K, Goto K, Abe I, Iida M. Angiotensin II receptor antagonist improves age-related endothelial dysfunction. J Hypertens 2002;20:439-46.
24. Mizuno M, Sada T, Ikeda M, Fukuda N, Miyamoto M, Yanagisawa H, et al. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur J Pharmacol 1995;285:181-8.
25. Iwase M, Tashiro K, Uchizono Y, Goto D, Yoshinari M. Pancreatic islet blood flow in conscious rats during hyperglycemia and hypoglycemia. Am J Physiol 2001;280:R1601-5.
26. Jansson L. Whole pancreatic blood flow and islet blood flow in hypovolemic hypotension in rats. Eur Surg Res 1992;24:291-7.
27. Jansson L. Evidence of an active regulation of pancreatic islet blood flow in rats. Studies in induced hypotension. Horm Metab Res 1993;25:651-2.
28. Lai EY, Jansson L, Patzak A, Persson AE. Vascular reactivity in arterioles from normal and alloxan-diabetic mice: studies on single perfused islets. Diabetes 2007;56:107-12.
29. Carlsson PO, Jansson L, Ostenson CG, Kallskog O. Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats. Diabetes 1997;46:947-52.
30. Tooke JE, editors. A pathophysiological framework for the pathogenesis of diabetic microangiopathy. Diabetic angiopathy. London: Arnold, 1999. pp. 187-96.
31. Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, Rickenbach K, et al. Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes 2006;55:625-33.
32. Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, et al. Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 2006;55:2965-73.
33. Cooper ME, Tikellis C, Thomas MC. Preventing diabetes in patients with hypertension: one more reason to block the renin-angiotensin system. J Hypertens, Suppl 24:S57-63.
34. Leung PS. Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes. Diabet Med 2007;24:110-16.
35. Holst JJ, Orskov C. The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism. Diabetes 2004;53Suppl 3:S197-204.
36. Svensson AM, Ostenson CG, Efendic S, Jansson L. Effects of glucagon-like peptide-1-(7-36)-amide on pancreatic islet and intestinal blood perfusion in Wistar rats and diabetic GK rats. Clin Sci 2007;112:345-51.
37. Hostetter TH, Rennke HG, Brenner BM. The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 1982;72:375-80.