Analysis and optimization of biochemical process reaction pathways. 2. Optimal selection of reaction steps for modification

Industrial and Engineering Chemistry Research

Volumn 37, Issue 12, 1998, Pages 4709-4714

  Conejeros, Haul ^a   Vassiliadis, Vassilios S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NONLINEAR SYSTEM; PROCESS OPTIMIZATION;

CHEMICAL MODIFICATION; FUNCTIONS; NONLINEAR PROGRAMMING; SENSITIVITY ANALYSIS;

BIOCHEMICAL PROCESS REACTIONS;

FERMENTATION;

ARTICLE; ATTENUATION; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME SUBSTRATE; FERMENTATION; NONHUMAN; PENICILLIUM CHRYSOGENUM; REACTION ANALYSIS; REACTION TIME;

EID: 0032455049     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie980411c     Document Type: Article

References (20)

1. Delgado, J.; Liao, J. C. Inverse flux analysis for reduction of acetate excretion in Escherichia coli. Biotechnol. Prog. 1997, 13, 361.
2. Jørgensen, H.; Nielsen, J.; Villadsen, J. Metabolic flux distributions in Penicilliun chrysogenum during fed-batch cultivations. Biotechnol Bioeng. 1995a, 46, 117.
3. Reagan, L.; Bogle, I. D. L.; Dunnill, P. Simulation and optimization of metabolic pathways. Comput. Chem. Eng. 1992, 16S, S237.
4. Reagan, L.; Bogle, I. D. L.; Dunnill, P. Simulation and optimization of metabolic pathways. Comput. Chem. Eng. 1993, 17, 627.
5. Voit, E. O. Optimization in integrated biochemical systems. Biotechnol. Bioeng. 1992, 40, 572.
6. Hatzimanikatis, V.; Floudas, C. A.; Bailey, J. E. Optimization of regulatory architectures in metabolic reaction networks. Biotechnol. Bioeng. 1996a, 52, 485.
7. Hatzimanikatis, V.; Floudas, C. A.; Bailey, J. E. Analysis and design of metabolic reaction networks via mixed-integer linear optimization. AIChE J. 1996b, 42, 1277.
8. Galazzo, J. L.; Bailey, J. E. Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae. Enzyme Microb. Technol. 1990, 12, 162.
9. Galazzo, J. L.; Bailey, J. E. Errata. Enzyme Microb. Technol. 1991, 13, 363.
10. Schlosser, P. M.; Holcomb, T.; Bailey, J. E. Determining metabolic sensitivity coefficients directly from experimental data. Biotechnol. Bioeng. 1993, 41, 1027.
11. Schlosser, P. M.; Riedy, G.; Bailey, J. E. Ethanol production in baker's yeast: Application of experimental perturbation techniques for model developement and resultant changes in flux control analysis. Biotechnol. Prog. 1994, 10, 141.
12. Torres, N. V.; Voit, E. O.; Glez-Alcon, C.; Rodriguez, F. An indirect optimization method for biochemical systems: Description of method and application to the maximization of the rate of ethanol, glycerol, and carbohydrate production in Saccharomyces cerevisiae. Biotechnol. Bioeng. 1997, 55, 759.
13. Savageau, M. Biochemical system analysis, i. some mathematical properties of the rate law for the component enzymatic reactions. J. Theor. Biol. 1969a, 25, 365.
14. Savageau, M. Biochemical system analysis, iii. dynamic solutions using a power-law approximation. J. Theor. Biol. 1970, 26, 215.
15. Savageau, M. Biochemical system analysis, ii. the steadystate solutions for an n-pool system using a power-law approximation. J. Theor. Biol. 1969b, 25, 370.
16. Hatzimanikatis, V.; Bailey, J. E. Effects of spatiotemporal variations on metabolic control: Approximate analysis using (log)linear kinetic models. Biotechnol. Bioeng. 1997, 54, 91.
17. Pissara, P. N.; Nielsen, J.; Bazin, M. J. Pathway kinetics and metabolic control analysis of a high-yielding strain of Pénicillium chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 1996, 51, 168.
18. Jørgensen, H.; Nielsen, J.; Villadsen, J.; Möllgaard, H. Analysis of penicillin v biosynthesis during fed-batch cultivations with a high-yielding strain of Pénicillium chrysogenum. Appl. Microbiol. Biotechnol. 1995b, 43, 123.
19. Nielsen, J.; Jørgensen, H. Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Pénicillium chrysogenum. Biotechnol. Prog. 1995, 11, 299.
20. gPROMS User's Guide, Version 0.1; Process Systems Enterprise Ltd.: London, 1996.