Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: A prospective randomized trial

Journal of Postgraduate Medicine

Volumn 55, Issue 1, 2009, Pages 22-26

  Chauhan, A ^a   Tiwari, S ^a   Mishra, V ^b   Bhatia, P ^a  

^a ARMY HOSPITAL RESEARCH AND REFERRAL   (India)

^b BASE HOSPITAL   (India)

Author keywords

Chemical sphincterotomy; Hemorrhoidectomy; Internal sphincterotomy; Pain relief; Topical Diltiazem

Indexed keywords

DILTIAZEM; PLACEBO; TRAMADOL;

ADULT; ANUS SPHINCTER; ARTICLE; CHI SQUARE TEST; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FISHER EXACT TEST; HEMORRHOID; HEMORRHOIDECTOMY; HOSPITAL DISCHARGE; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OINTMENT; PAIN ASSESSMENT; POSTOPERATIVE ANALGESIA; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPHINCTEROTOMY; STUDENT T TEST; TREATMENT DURATION; VISUAL ANALOG SCALE; WORK RESUMPTION;

ADMINISTRATION, TOPICAL; ADULT; AGED; CALCIUM CHANNEL BLOCKERS; DIGESTIVE SYSTEM SURGICAL PROCEDURES; DILTIAZEM; FEMALE; HEMORRHOIDS; HUMANS; MALE; MIDDLE AGED; OINTMENTS; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; TRAMADOL; TREATMENT OUTCOME;

EID: 61649100789     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: 10.4103/0022-3859.48436     Document Type: Article

References (29)

1. Watts MJ. Healing and pain after hemorrhoidectomy. BMJ 1964;51:808-17.
2. Asfar SK, Juma TH, Ala-Edeen T. Hemorrhoidectomy and sphincterotomy in reducing pain after hemorrhoidectomy. Dis Colon Rectum 1988;31:181-5.
3. Di Bella F, Estenne G. Indication for internal, medial posterior with anoplasty or left lateral sphinctertotomy during hemorrhoidectomy: Our experience. Minerva Chir 1990;45:361-3.
4. Tan KY, Sng KK, Tay KH, Lai JH, Eu KW. Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy. Br J Surg 2006;93:1464-8.
5. Patti R, Arcara M, Padronaggio D, Bonventre S, Angileri M, Salerno R, et al. Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing. Chir Ital 2005;57:77-85.
6. Flaherty SA. Pain measurement tools for clinical practice and research. AANA J 1996;64:133-40.
7. Jorge JM, Wexner SD. Anorectal manometry: Techniques and clinical applications. South Med J 1993;86:924-31.
8. Hosch SB, Knoefel WT, Pichlmeier U, Schulze V, Busch C, Gawad KA, et al. Surgical treatment of piles: Prospective, randomized study of Parks vs. Milligan-Morgan haemorrhoidectomy. Dis Colon Rectum 1998;41:159-64.
9. Schouten WR, van Vroonhoven TJ. Lateral internal sphincterotomy in the treatment of hemorrhoids: A clinical and manometric study. Dis Colon Rectum 1986;29:869-72.
10. Eisehammer S. Internal anal sphincterotomy plus free dilatation versus anal stretch with special criticism of the anal stretch procedure for hemorrhoids: The recommended modern approach to hemorrhoids treatment. Dis Colon Rectum 1974;17:493-522.
11. Goligher JC. Surgery of anus, rectum and colon. 5th ed. London: Bailliere Tindall; 1984. p. 98.
12. Galizia G, Lieto E, Castellano P, Pelosio L, Imperatore V, Pignatelli C. Lateral internal sphincterotomy together with Hemorrhoidectomy for treatment of Hemorrhoids: A randomized prospective study. Eur J Surg 2000;166:223-8.
13. Kanellos I, Zacharakis E, Christoforidis E, Angelopoulos S, Kanellos D, Pramateftakis MG, et al. Usefulness of lateral internal sphicterotomy in reducing post operative pain after open hemorrhoidectomy. World J Surg 2005;29:464-8.
14. Altomare DF, Rinaldi M, Milito G, Arcanà F, Spinelli F, Nardelli N, et al. Glyceryl trinitrate for chronic anal fissure- healing or headache? Results of a multicenter, randomized, placebo-controlled, double-blind trial. Dis Colon Rectum 2000;43:174-9.
15. Schouten WR, Briel JW, Boerma MO, Auwerda JJ, Wilms EB, Graatsma BH. Pathophysiological outcome of intra-anal application of isosorbide dinitrate in patients of chronic anal fissure. Gut 1996;397:465-9.
16. Parellada C. Randomized prospective trial comparing 0.2 percent isosor bide dinitrate ointment with sphincterotomy in treatment of chronic anal fissure: A two- year follow-up. Dis Colon Rectum 2004;47:437-43.
17. Katsinelos P, Kountouras J, Paroutoglou G, Beltsis A, Chatzimavroudis G, Zavos C, et al. Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. World J Gastroenterol 2006;12:6203-6.
18. Ezri T, Susmallian S. Topical nifedipine vs topical glyceryl trinitrate for treatment of chronic anal fissure. Dis Colon Rectum 2003;46:805-8
19. Bielecki K, Kolodziejczak M. A prospective randomised trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. Colorectal Dis 2003;5:256-7.
20. Carapeti EA, Kamm M, Phillips R. Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissure without side effects. Dis Colon Rectum 2000;43:1359-62.
21. Jonas M, Neal KR, Abercrombie JF, Scholefield JH. A randomized trial of oral vs. topical diltiazem for chronic anal fissures. Dis Colon Rectum 2001;44:1074-8.
22. Silverman R, Bendick PJ, Wasvary HJ. A randomized, prospective double-blind, placebo - controlled trial of the effect of a calcium channel blocker ointment on pain after haemorrhoidectomy. 2005;48:1913-6.
23. Steele SR. Madoff RD. Systematic review: The treatment of anal fissure. Aliment Pharmacol Ther 2006;24:247-57.
24. Alper D, Ram E, Gideon YS, Dreznik Z. Resting anal pressure following hemorrhoidectomy and lateral sphincterotomy. Dis Colon Rectum 2005;48:2080-4.
25. Ho YH, Tan M. Ambulatory anorectal manometric findings in patients before and after haemorrhoidectomy. Int J Colorectal Dis 1997;12:296-7.
26. Brown CJ, Dubreuil D, Santoro L, Liu M, O'Connor BI, McLeod RS. Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: Six-year follow-up of a multicenter, randomized, controlled trial. Dis Colon Rectum 2007;13:134-8
27. Mathai V, Ong BC, Ho YH. Randomised controlled trial of lateral internal sphicterotomy with haemorrhoidectomy. Br J Surg 1996;83:380-2.
28. Khubchandani IT. Internal sphincterotomy with hemorrhoidectomy does not relieve pain: A prospective, randomized study. Dis Colon Rectum 2002;45:1452-7.
29. Amorotti C, Mosca D, Trenti C, Pintaudi U. Usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy by the Milligan-Morgan's technique: Results of a prospective randomized trial. Chir Ital 2003;55:879-86.