Management options for minimal hepatic encephalopathy

Expert Review of Gastroenterology and Hepatology

Volumn 2, Issue 6, 2008, Pages 785-790

  Bajaj, Jasmohan S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cirrhosis; Critical flicker; Inhibitory control test; Lactulose; Minimal hepatic encephalopathy; Probiotics; Psychometric test; Traffic accident

Indexed keywords

ACARBOSE; ACETYLCARNITINE; LACTULOSE; PROBIOTIC AGENT; RIFAXIMIN;

ATTENTION DEFICIT DISORDER; COGNITIVE DEFECT; COMMUNICATION DISORDER; CRITICAL FLICKER FUSION; DRIVING ABILITY; DRUG EFFICACY; ELECTROCORTICOGRAPHY; EVOKED RESPONSE; HEPATIC ENCEPHALOPATHY; HUMAN; LEARNING DISORDER; LIVER CIRRHOSIS; MINIMAL HEPATIC ENCEPHALOPATHY; NEUROPSYCHOLOGICAL TEST; PATIENT COMPLIANCE; PSYCHOMETRY; QUALITY OF LIFE; REVIEW; TRAFFIC ACCIDENT; UNSPECIFIED SIDE EFFECT; COGNITION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

COGNITION; HEPATIC ENCEPHALOPATHY; HUMANS; LACTULOSE; PROBIOTICS; PSYCHOMETRICS;

EID: 61549097213     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/17474124.2.6.785     Document Type: Review

References (51)

1. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification. Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35, 716-721 (2002).
2. Ortiz M, Jacas C, Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J. Hepatol. 42(Suppl.), S45-S53 (2005).
3. Li YY, Nie YQ, Sha WH et al. Prevalence of subclinical hepatic encephalopathy in cirrhotic patients in China. World. J. Gastroenterol. 10, 2397-2401 (2004).
4. Blei AT, Cordoba J. Hepatic encephalopathy. Am. J. Gastroenterol. 96, 1968-1976 (2001).
5. Cordoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology 27, 339-345 (1998).
6. Stewart CA, Smith GE. Minimal hepatic encephalopathy. Nat. Clin. Pract. Gastroenterol. Hepatol. 4, 677-685 (2007).
7. Talwalkar JA, Kamath PS. Influence of recent advances in medical management on clinical outcomes of cirrhosis. Mayo Clin. Proc. 80, 1501-1508 (2005).
8. Groeneweg M, Quero JC, De Bruijn I et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28, 45-49 (1998).
9. Wein C, Koch H, Popp B, Oehler G, Schauder P. Minimal hepatic encephalopathy impairs fitness to drive. Hepatology 39, 739-745 (2004).
10. Bajaj JS, Hafeezullah M, Hoffmann RG, Saeian K. Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations. Am. J. Gastroenterol. 102, 1903-1909 (2007).
11. Bajaj JS, Hafeezullah M, Hoffmann RG et al. Navigation skill impairment: another dimension of the driving difficulties in minimal hepatic encephalopathy. Hepatology 47, 596-604 (2008).
12. Romero-Gomez M, Boza F, Garcia-Valdecasas MS, Garcia E, Aguilar-Reina J. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am. J. Gastroenterol. 96, 2718-2723 (2001).
13. Hartmann IJ, Groeneweg M, Quero JC et al. The prognostic significance of subclinical hepatic encephalopathy. Am. J. Gastroenterol. 95, 2029-2034 (2000).
14. Weissenborn K, Ennen JC, Schomerus H, Ruckert N, Hecker H. Neuropsychological characterization of hepatic encephalopathy. J. Hepatol. 34, 768-773 (2001).
15. Ortiz M, Cordoba J, Jacas C, Flavia M, Esteban R, Guardia J. Neuropsychological abnormalities in cirrhosis include learning impairment. J. Hepatol. 44, 104-110 (2006).
16. Weissenborn K, Giewekemeyer K, Heidenreich S, Bokemeyer M, Berding G, Ahl B. Attention, memory, and cognitive function in hepatic encephalopathy. Metab. Brain Dis. 20, 359-367 (2005).
17. Bajaj JS, Saeian K, Verber MD et al. Inhibitory control test is a simple method to diagnose minimal hepatic encephalopathy and predict development of overt hepatic encephalopathy. Am. J. Gastroenterol. 102, 754-760 (2007).
18. Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 45, 549-559 (2007).
19. Ortiz M, Cordoba J, Doval E et al. Development of a clinical hepatic encephalopathy staging scale. Aliment. Pharmacol. Ther. 26, 859-867 (2007).
20. Amodio P, Campagna F, Olianas S et al. Detection of minimal hepatic encephalopathy: normalization and optimization of the psychometric hepatic encephalopathy score. A neuropsychological and quantified EEG study. J. Hepatol. 49, 346-353 (2008).
21. Romero Gomez M, Cordoba J, Jover R et al. [Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy]. Med. Clin. (Barc.) 127, 246-249 (2006).
22. Mooney S, Hasssanein TI, Hilsabeck RC et al. Utility of the repeatable battery for the assessment of neuropsychological status (RBANS) in patients with end-stage liver disease awaiting liver transplant. Arch. Clin. Neuropsychol. 22, 175-186 (2007).
23. Sorrell JH, Zolnikov BJ, Sharma A, Jinnai I. Cognitive impairment in people diagnosed with end-stage liver disease evaluated for liver transplantation. Psychiatry Clin. Neurosci. 60, 174-181 (2006).
24. Montagnese S, Jackson C, Morgan MY. Spatio-temporal decomposition of the electroencephalogram in patients with cirrhosis. J. Hepatol. 46, 447-458 (2007).
25. Amodio P, Del Piccolo F, Petteno E et al. Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. J. Hepatol. 35, 37-45 (2001).
26. Saxena N, Bhatia M, Joshi YK, Garg PK, Tandon RK. Auditory P300 event-related potentials and number connection test for evaluation of subclinical hepatic encephalopathy in patients with cirrhosis of the liver: a follow-up study. J. Gastroenterol. Hepatol. 16, 322-327 (2001).
27. Jones EA, Giger-Mateeva VI, Reits D, Riemslag FC, Liberov B, Spekrijse H. Visual event-related potentials in cirrhotic patients without overt encephalopathy: the effects of flumazenil. Metab. Brain Dis. 16, 43-53 (2001).
28. Yang SS, Wu CH, Chiang TR, Chen DS. Somatosensory evoked potentials in subclinical portosystemic encephalopathy: a comparison with psychometric tests. Hepatology 27, 357-361 (1998).
29. Kugler CF, Lotterer E, Petter J et al. Visual event-related P300 potentials in early portosystemic encephalopathy. Gastroenterology 103, 302-310 (1992).
30. Vergara-Gomez M, Flavia-Olivella M, Gil-Prades M, Dalmau-Obrador B, Cordoba-Cardona J. [Diagnosis and treatment of hepatic encephalopathy in Spain: results of a survey of hepatologists]. Gastroenterol. Hepatol. 29, 1-6 (2006).
31. Bajaj JS, Etemadian A, Hafeezullah M, Saeian K. Testing for minimal hepatic encephalopathy in the United States: an AASLD survey. Hepatology 45, 833-834 (2007).
32. Bajaj JS, Hafeezullah M, Franco J et al. Inhibitory control test for the diagnosis of minimal hepatic encephalopathy. Gastroenterology. 135(5), 1591-1600.e1 (2008).
33. Kircheis G, Wettstein M, Timmermann L, Schnitzler A, Haussinger D. Critical flicker frequency for quantification of low-grade hepatic encephalopathy. Hepatology 35, 357-366 (2002).
34. Mardini H, Saxby BK, Record CO. Computerized psychometric testing in minimal encephalopathy and modulation by nitrogen challenge and liver transplant. Gastroenterology 135(5), 1582-1590 (2008).
35. Sharma P, Sharma BC, Puri V, Sarin SK. Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy. J. Hepatol. 47, 67-73 (2007).
36. Romero-Gomez M, Cordoba J, Jover R et al. Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology 45, 879-885 (2007).
37. Mullen K, Ferenci P, Bass NM, Leevy CB, Keeffe E. An algorithm for the management of hepatic encephalopathy. Sem. Liver Dis. 27, 32-48 (2007).
38. Das A, Dhiman RK, Saraswat VA, Verma M, Naik SR. Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J. Gastroenterol. Hepatol. 16, 531-535 (2001).
39. Bajaj JS, Ananthakrishnan AN, McGinley E, Hoffmann RG, Brasel KJ. Deleterious impact of cirrhosis on outcomes after motor vehicle crashes using the Nationwide Inpatient Sample. Am. J. Gastroenterol. 103(7), 1674-1681 (2008).
40. Bajaj JS, Saeian K, Hafeezullah M, Hoffmann RG, Hammeke TA. Patients with minimal hepatic encephalopathy have poor insight into their driving skills. Clin. Gastroenterol. Hepatol. 6, 1135-1139; quiz 1065 (2008).
41. Watanabe A, Sakai T, Sato S et al. Clinical efficacy of lactulose in cirrhotic patients with and without subclinical hepatic encephalopathy. Hepatology 26, 1410-1414 (1997).
42. Dhiman RK, Sawhney MS, Chawla YK, Das G, Ram S, Dilawari JB. Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy. Dig. Dis. Sci. 45, 1549-1552 (2000).
43. Mullen KD, Amodio P, Morgan MY. Therapeutic studies in hepatic encephalopathy. Metab. Brain Dis. 22, 407-423 (2007).
44. Malaguarnera M, Gargante MP, Cristaldi E et al. Acetyl-[s L s]-carnitine treatment in minimal hepatic encephalopathy. Dig. Dis. Sci. 53(11), 3018-3025 (2008).
45. Gentile S, Guarino G, Romano M et al. A randomized controlled trial of acarbose in hepatic encephalopathy. Clin. Gastroenterol. Hepatol. 3, 184-191 (2005).
46. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (fos) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig. Dis. Sci. 52, 3259-3265 (2007).
47. Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 39, 1441-1449 (2004).
48. Boca M, Vyskocil M, Mikulecky M et al. [Complex therapy of chronic hepatic encephalopathy supplemented with probiotic: comparison of two studies]. Cas. Lek. Cesk. 143, 324-328 (2004).
49. Macbeth WA, Kass EH, McDermott WV Jr. Treatment of hepatic encephalopathy by alteration of intestinal flora with Lactobacillus acidophilus. Lancet 191, 399-403 (1965).
50. Bajaj JS, Saeian K, Christensen KM et al. Probiotic yogurt for the treatment of minimal hepatic encephalopathy. Am. J. Gastroenterol. 103, 1707-1715 (2008).
51. Sharma P, Sharma BC, Puri V, Sarin SK. An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy. Eur. J. Gastroenterol. Hepatol. 20, 506-511 (2008).