Detection of minimal hepatic encephalopathy: Normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study

Journal of Hepatology

Volumn 49, Issue 3, 2008, Pages 346-353

  Amodio, Piero ^a   Campagna, Francesca ^a   Olianas, Stefania ^a   Iannizzi, Pamela ^a   Mapelli, Daniela ^a   Penzo, Marco ^a   Angeli, Paolo ^a   Gatta, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Liver cirrhosis; Mild cognitive impairment; Minimal hepatic encephalopathy; Psychometric tests; Spectral EEG

Indexed keywords

ADULT; ARTICLE; CALCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EDUCATIONAL STATUS; ELECTROENCEPHALOGRAM; FEMALE; GERMANY; HEPATIC ENCEPHALOPATHY; HUMAN; ITALY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PREDICTOR VARIABLE; PRIORITY JOURNAL; PSYCHOMETRIC HEPATIC ENCEPHALOPATHY SCORE; PSYCHOMETRY; SPAIN; STATISTICAL SIGNIFICANCE;

AGED; ATTENTION; DISEASE PROGRESSION; ELECTROENCEPHALOGRAPHY; FEMALE; GERMANY; HEPATIC ENCEPHALOPATHY; HUMANS; INTELLIGENCE TESTS; ITALY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMETRICS; PSYCHOMOTOR PERFORMANCE; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SPACE PERCEPTION; SPAIN; VISUAL PERCEPTION;

EID: 48449094761     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.04.022     Document Type: Article

References (28)

1. Amodio P., Montagnese S., Gatta A., and Morgan M.Y. Characteristics of minimal hepatic encephalopathy. Metab Brain Dis 19 (2004) 253-267
2. Lockwood A.H. "What's in a name?" Improving the care of cirrhotics. J Hepatol 32 (2000) 859-861
3. Amodio P., Del Piccolo F., Marchetti P., Angeli P., Iemmolo R., Caregaro L., et al. Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests. Hepatology 29 (1999) 1662-1667
4. Amodio P., Del Piccolo F., Petteno E., Mapelli D., Angeli P., Iemmolo R., et al. Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients. J Hepatol 35 (2001) 37-45
5. Saxena N., Bhatia M., Joshi Y.K., Garg P.K., Dwivedi S.N., and Tandon R.K. Electrophysiological and neuropsychological tests for the diagnosis of subclinical hepatic encephalopathy and prediction of overt encephalopathy. Liver 22 (2002) 190-197
6. Wein C., Koch H., Popp B., Oehler G., and Schauder P. Minimal hepatic encephalopathy impairs fitness to drive. Hepatology 39 (2004) 739-745
7. Groeneweg M., Quero J.C., De Bruijn I., Hartmann I.J., Essink-bot M.L., Hop W.C., et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28 (1998) 45-49
8. Schomerus H., and Hamster W. Quality of life in cirrhotics with minimal hepatic encephalopathy. Metab Brain Dis 16 (2001) 37-41
9. Amodio P., Marchetti P., Del Piccolo F., Campo G., Rizzo C., Iemmolo R.M., et al. Visual attention in cirrhotic patients: a study on covert visual attention orienting. Hepatology 27 (1998) 1517-1523
10. Amodio P., Schiff S., Del Piccolo F., Mapelli D., Gatta A., and Umilta C. Attention dysfunction in cirrhotic patients: an inquiry on the role of executive control, attention orienting and focusing. Metab Brain Dis 20 (2005) 115-127
11. Tarter R.E., Hegedus A.M., Van Thiel D.H., Schade R.R., Gavaler J.S., and Starzl T.E. Non alcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy. Gastroenterology 86 (1984) 1421-1427
12. Weissenborn K., Giewekemeyer K., Heidenreich S., Bokemeyer M., Berding G., and Ahl B. Attention, memory, and cognitive function in hepatic encephalopathy. Metab Brain Dis 20 (2005) 359-367
13. Weissenborn K., Heidenreich S., Ennen J., Ruckert N., and Hecker H. Attention deficits in minimal hepatic encephalopathy. Metab Brain Dis 16 (2001) 13-19
14. Schiff S., Vallesi A., Mapelli D., Orsato R., Pellegrini A., Umilta C., et al. Impairment of response inhibition precedes motor alteration in the early stage of liver cirrhosis: a behavioral and electrophysiological study. Metab Brain Dis 20 (2005) 381-392
15. Schomerus H., and Hamster W. Neuropsychological aspects of portal-systemic encephalopathy. Metab Brain Dis 13 (1998) 361-377
16. Weissenborn K., Ennen J.C., Schomerus H., Ruckert N., and Hecker H. Neuropsychological characterization of hepatic encephalopathy. J Hepatol 34 (2001) 768-773
17. Ferenci P., Lockwood A., Mullen K., Tarter R., Weissenborn K., and Blei A.T. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35 (2002) 716-721
18. Lockwood A.H., Murphy B.W., Donnelly K.Z., Mahl T.C., and Perini S. Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy. Hepatology 18 (1993) 1061-1068
19. Douglass A., Al Mardini H., and Record C. Amino acid challenge in patients with cirrhosis: a model for the assessment of treatments for hepatic encephalopathy. J Hepatol 34 (2001) 658-664
20. Romero-Gómez M., Cordoba J., Jover R., del Olmo J., Fernandez A., Flavia M., et al. Tablas de normalidad de la poblacion espanola para los tests psicometricos utilizados en el diagnostico de la encefalopatia hepatica minima. Med Clin (Barc) 127 (2006) 246-249
21. Romero-Gómez M., Cordoba J., Jover R., del Olmo J.A., Ramirez M., Rey R., et al. Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology 45 (2007) 879-885
22. Amodio P., Wenin H., Del Piccolo F., Mapelli D., Montagnese S., Pellegrini A., et al. Variability of trail making test, symbol digit test and line trait test in normal people. A normative study taking into account age-dependent decline and sociobiological variables. Aging Clin Exp Res 14 (2002) 117-131
23. Klem G.H., Lüders H.O., Jasper H.H., and Elger C. The ten-twenty electrode system of the International Federation. In: Deuschal G., and Eisen A. (Eds). Recommandations for the practice of clinical neurophysiology: guidelines of the international federation of clinical neurophysiology (1999), Elsevier, Amsterdam 3-6
24. Amodio P., Marchetti P., Del Piccolo F., de Tourtchaninoff M., Varghese P., Zuliani C., et al. Spectral versus visual EEG analysis in mild hepatic encephalopathy. Clin Neurophysiol 110 (1999) 1334-1344
25. Bland J.M., and Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1 (1986) 307-310
26. Quero J.C., Hartmann I.J., Meulstee J., Hop W.C., and Schalm S.W. The diagnosis of subclinical hepatic encephalopathy in patients with cirrhosis using neuropsychological tests and automated electroencephalogram analysis. Hepatology 24 (1996) 556-560
27. Weissenborn K., Ruckert N., Hecker H., and Manns M.P. The number connection tests A and B: interindividual variability and use for the assessment of early hepatic encephalopathy. J Hepatol 28 (1998) 646-653
28. Amodio P., Quero J.C., Del Piccolo F., Gatta A., and Schalm S.W. Diagnostic tools for the detection of subclinical hepatic encephalopathy: comparison of standard and computerized psychometric tests with spectral-EEG. Metab Brain Dis 11 (1996) 315-327