Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas

Oncology Reports

Volumn 21, Issue 1, 2009, Pages 19-24

  Hong, Sung P ^a   Lee, Eun K ^a   Park, Jeong Y ^a   Jeon, Tae J ^b   Bang, Seungmin ^a   Park, Seungwoo ^a   Chung, Jae B ^a   Lee, Woo J ^a   Kim, Hoguen ^a   Song, Si Young ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

Cripto 1; Immunohistochemistry; Intraductal papillary mucinous neoplasm; Real time RT PCR; Tumorigenesis

Indexed keywords

CRIPTO 1 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR; TDGF1 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER TISSUE; CARCINOGENESIS; CARCINOGENICITY; CARCINOMA IN SITU; CELL INVASION; CELL TRANSFORMATION; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INVASIVE CARCINOMA; MALE; PANCREAS ADENOMA; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CLASSIFICATION; UPREGULATION; ADENOCARCINOMA; BIOSYNTHESIS; COLLOID CARCINOMA; GENE EXPRESSION; METABOLISM; MIDDLE AGED; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY;

ADENOCARCINOMA, MUCINOUS; ADENOCARCINOMA, PAPILLARY; ADULT; AGED; CARCINOMA, PANCREATIC DUCTAL; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 61449562125     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000184     Document Type: Article

References (37)

1. Sessa F, Solcia E, Capella C, et al: Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425: 357-367, 1994.
2. Rickaert F, Cremer M, Devière J, et al: Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology 101: 512-519, 1991.
3. Sugiyama M and Atomi Y: Intraductal papillary mucinous tumors of the pancreas: imaging studies and treatment strategies. Ann Surg 228: 685-691, 1998.
4. Furukawa T, Klöppel G, Volkan Adsay N, et al: Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447: 794-799, 2005.
5. Shen MM and Schier AF: The EGF-CFC gene family in vertebrate development. Trends Genet 16: 303-309, 2000.
6. Minchiotti G, Parisi S, Liguori G, et al: Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Mech Dev 90: 133-142, 2000.
7. Yan YT, Liu JJ, Luo Y, et al: Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol 22: 4439-4449, 2002.
8. Saloman DS, Bianco C, Ebert AD, et al: The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer. Endocr Relat Cancer 7: 199-226, 2000.
9. Schier AF: Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol 19: 589-621, 2003.
10. Ciardiello F, Dono R, Kim N, Persico MG and Salomon DS: Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line. Cancer Res 51: 1051-1054, 1991.
11. Wechselberger C, Ebert AD, Bianco C, et al: Cripto-1 enhances migration and branching morphogenesis of mouse mammary epithelial cells. Exp Cell Res 266: 95-105, 2001.
12. Bianco C, Strizzi L, Ebert A, et al: Role of human cripto-1 in tumor angiogenesis. J Natl Cancer Inst 97: 132-141, 2005.
13. Ciardiello F, Kim N, Saeki T, et al: Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci USA 88: 7792-7796, 1991.
14. Qi CF, Liscia DS, Normanno N, et al: Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. Br J Cancer 69: 903-910, 1994.
15. Fontanini G, De Laurentiis M, Vignati S, et al: Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 4: 241-249, 1998.
16. Friess H, Yamanaka Y, Büchler M, Kobrin MS, Tahara E and Korc M: Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. Int J Cancer 56: 668-674, 1994.
17. Allgayer H, Heiss MM and Schildberg FW: Prognostic factors in gastric cancer. Br J Surg 84: 1651-1664, 1997.
18. Saeki T, Stromberg K, Qi CF, et al: Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors. Cancer Res 52: 3467-3473, 1992.
19. Kim HS, Park KH, Kim SA, et al: Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint. Mutat Res 578: 187-201, 2005.
20. Jesnowski R, Backhaus C, Ringel J and Lohr M: Ribosomal highly basic 23-kDa protein as a reliable standard for gene expression analysis. Pancreatology 2: 421-424, 2002.
21. Kim JJ, Li JJ, Jung DS, et al: Differential expression of nephrin according to glomerular size in early diabetic kidney disease. J Am Soc Nephrol 18: 2303-2310, 2007.
22. Niemeyer CC, Persico MG and Adamson ED: Cripto: roles in mammary cell growth, survival, differentiation and transformation. Cell Death Differ 5: 440-449, 1998.
23. Strizzi L, Bianco C, Normanno N, et al: Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice. J Cell Physiol 201: 266-276, 2004.
24. Wechselberger C, Strizzi L, Kenney N, et al: Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma. Oncogene 24: 4094-4105, 2005.
25. Park PW, Reizes O and Bernfield M: Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters. J Biol Chem 275: 29923-29926, 2000.
26. Bianco C, Strizzi L, Rehman A, et al: A nodal- and ALK4-independent signaling pathway activated by Cripto-1 through glypican-1 and c-src. Cancer Res 63: 1192-1197, 2003.
27. Kannan S, De Santis M, Lohmeyer M, et al: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem 272: 3330-3335, 1997.
28. Ebert AD, Wechselberger C, Frank S, et al: Cripto-1 induces phosphatidylinositol 3′-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. Cancer Res 59: 4502-4505, 1999.
29. Gray PC, Harrison CA and Vale W: Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc Natl Acad Sci USA 100: 5193-5198, 2003.
30. Kuniyasu H, Yoshida K, Yokozaki H, et al: Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas. Jpn J Cancer Res 82: 969-973, 1991.
31. Normanno N, Kim N, Wen D, et al: Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas. Breast Cancer Res Treat 35: 293-297, 1995.
32. Osako M, Yonezawa S, Siddiki B, et al: Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer 71: 2191-2199, 1993.
33. Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DT and Kim YS: Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem 264: 6480-6487, 1989.
34. Ho SB, Niehans GA, Lyftogt C, et al: Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 53: 641-651, 1993.
35. Nakamura A, Horinouchi M, Goto M, et al: New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol 197: 201-210, 2002.
36. Bianco C, Strizzi L, Mancino M, et al: Identification of cripto-1 as a novel serologic marker for breast and colon cancer. Clin Cancer Res 12: 5158-5164, 2006.
37. Xing PX, Hu XF, Pietersz GA, Hosick HL and McKenzie IF: Cripto: a novel target for antibody-based cancer immunotherapy. Cancer Res 64: 4018-4023, 2004.