Yeast-secreted recombinant extracellular domain of human CD105 antigen is able to bind TGF-beta type II receptor in vitro

Molecular Biotechnology

Volumn 41, Issue 1, 2009, Pages 26-34

  Basile, Giancarlo ^a,b   Peticca, Manuela ^a   Cusano, Patrizia ^a   Catello, Sergio ^a  

^a Tecnogen SpA   (Italy)

^b Exelgen Ltd   (United Kingdom)

Author keywords

CD105 antigen; Cell wall; PDI; Saccharomyces cerevisiae; vrg

Indexed keywords

ANIMAL CELL CULTURE; CELL MEMBRANES; ENDOTHELIAL CELLS; ENZYME ACTIVITY; POLYMERS; YEAST;

CD105 ANTIGEN; CELL WALL; PDI; SACCHAROMYCES CEREVISIAE; VRG;

ANTIGENS;

ENDOGLIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PROTEIN DISULFIDE ISOMERASE; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; CELL STRAIN HL 60; GENETICS; METABOLISM; MOLECULAR CLONING;

SACCHAROMYCES CEREVISIAE;

ANTIGENS, CD; CLONING, MOLECULAR; HL-60 CELLS; HUMANS; PROTEIN DISULFIDE-ISOMERASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CELL SURFACE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 61449505181     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-008-9091-2     Document Type: Article

References (39)

1. A Gougos M Letarte 1990 Primary structure of endoglin, an RGD-containing glycoprotein of human Endothelial cells Journal of Biological Chemistry 265 15 8361 8364
2. A Gougos M Letarte 1988 Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line Journal of Immunology 141 1925 1933
3. EJ Quackenbush M Letarte 1985 Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies Journal of Immunology 134 2 1276 1284
4. S Cheifetz T Bellon C Cales S Vera C Bernabeu J Massaguè M Letarte 1992 Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells Journal of Biological Chemistry 267 19027 19030
5. T Bellon A Corbi P Lastres C Cales M Cebrian S Vera S Cheifetz J Massague M Letarte C Bernabeu 1993 Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions European Journal of Immunology 23 9 2340 2345
6. NP Barbara JL Wrana M Letarte 1999 Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of transforming growth factor β superfamily Journal of Biological Chemistry 274 8 584 594
7. M Altomonte R Montagner E Fonsatti F Colizzi I Cattarossi LI Brasoveanu MR Nicotra A Cattelan PG Natali M Maio 1996 Expression and structural features of endoglin (CD105), a transforming growth factor β1 and β3 binding protein, in human melanoma British Journal of Cancer 74 1586 1591
8. HJ Buhring CA Muller M Letarte A Gougos A Saalmuller A Van Agthoven FW Busch 1991 Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow Leukemia 5 10 841 847
9. RD Marshall 1974 The nature and metabolism of the carbohydrate-peptide linkages of glycoproteins Biochemical Society Symposium 40 17 20
10. U Raab B Velasco P Lastres A Letamendia C Cales C Langa E Tapia JP Lopez-Bote E Paez C Bernabeu 1999 Expression of normal and truncated forms of human endoglin Biochemical Journal 339 579 588
11. N Pece U Cymerman S Vera DA Marchuk M Letarte 1999 Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1 Human Molecular Genetics 8 12 2171 2181
12. KA McAllister KM Grogg DW Johnson CJ Gallione MA Baldwin CE Jackson EA Helmbold DS Markel WC McKinnon J Murrell MK McCormick MA Pericack-Vance P Heutink BA Oostra T Haitjema CJJ Westerman ME Porteus AE Guttmacher M Letarte DA Marchuk 1994 Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 Nature Genetics 8 345 351
13. P Bertolino M Deckers F Lebrin P ten Dijke 2005 Transforming growth factor-b signal transduction in angiogenesis and vascular disorders Chest 128 585S 5090S
14. H Yamashita H Ichijo S Grimsby A Morén P Ten Dijke K Miyazono 1994 Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta Journal of Biological Chemistry 269 1995 2001
15. H Zhang ARE Shaw A Mak M Letarte 1996 Endoglin is a component of the transforming growth factor (TGF)-beta receptor complex of human pre-B leukemic cells Journal of Immunology 156 565 573
16. P Lastres A Letamendia H Zhang C Rius N Almendro U Raab LA Lopez C Langa A Fabra M Letarte C Bernabéu 1996 Endoglin modulates cellular responses to TGF-beta 1 Journal of Cell Biology 133 5 1109 1121
17. T Bellon A Corbi P Lastres C Cales M Cebrian S Vera S Cheifetz J Massague M Letarte C Bernabeu 1997 Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions European Journal of Immunology 23 9 2340 2345
18. S Pichuantes S Vera A Bourdeau N Pece S Kumar EA Wayner M Letarte 1997 Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments Tissue Antigens 50 3 265 276
19. RG Buckholz MAG Gleeson 1991 Yeast systems for the commercial production of heterologous proteins Biotechnology 9 11 1067 1072
20. MA Romanos CA Scorer JJ Clare 1992 Foreign gene expression in yeast: a review Yeast 8 6 423 488
21. Sambrook, J., Fritsch, E. F., & Maniatis, T. (1989). Molecular cloning: a laboratory manual. Cold Spring Harbor, New York, NY: Cold Spring Harbor Laboratory Press.
22. H Hashimoto H Morikawa Y Yamada A Kimura 1985 A novel method for transformation of intact yeast cells by electroinjection of plasmid DNA Applied Microbiology and Biotechnology 21 336 339
23. L Ballou RA Hitzeman MS Lewis CE Ballou 1991 Vanadate-resistant yeast mutants are defective in protein glycosylation Proceedings of the National Academy of Sciences of the United States of America 88 3209 3212
24. CK Ennulat E Montalvo N Neff 1995 Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in golgi-mediated protein glycosylation, sporulation and detergent resistance Genetics 140 933 943
25. CE Ballou 1990 Isolation, characterization, and properties of Saccharomyces cerevisiae mnn mutants with nonconditional protein glycosylation defects Methods in Enzymology 185 440 470
26. Kaiser, C., Michaelis, S., & Mitchell, A. (1994). Methods in yeast genetics. Cold Spring Harbor, New York, NY: Cold Spring Harbor Laboratory Press.
27. M Kozak 1986 Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes Cell 44 2 283 292
28. FM Klis P Mol K Hellingwerf S Brul 2002 Dynamic of cell wall structure in Saccharomyces cerevisiae FEMS Microbiology Reviews 26 239 256
29. D Bartkeviciute K Sasnauskas 2004 Disruption of the MNN10 gene enhances protein secretion in Kluyveromyces lactis and Saccharomyces cerevisiae FEMS Yeast Research 4 833 840
30. D Bartkeviciute K Sasnauskas 2003 Studies of yeast Kluyveromyces lactis mutations conferring super-secretion of recombinant proteins Yeast 20 1 1 11
31. JC Edman L Ellis RW Blacher RA Roth WJ Rutter 1985 Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin Nature 317 6034 267 270
32. AC Mustilli E Izzo M Houghton CL Galeotti 1999 Comparison of secretion of a hepatitis C virus glycoprotein in Saccharomyces cerevisiae and Kluyveromyces lactis Research in Microbiology 150 3 179 187
33. A Herscovics P Orlean 1993 Glycoprotein biosynthesis in yeast FASEB Journal 7 540 550
34. VJ Cid A Duran F Del Rey MP Snyder C Nombela M Sanchez 1995 Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae Microbiological Reviews 59 3 345 386
35. VE Klyushnichenko AN Wulfson 1993 Recombinant human insulin-II. Size-exclusion HPLC of biotechnological precursors. Factors influencing on retention and selectivity Pure and Applied Chemistry 65 10 2265 2272
36. KJ Woycechowsky DK Wittrup RT Raines 1999 A small-molecule catalyst of protein folding in vitro and in vivo Chemistry & Biology 6 12 871 879
37. P ten Dijke CS Hill 2004 New insights into TGF-beta-Smad signalling Trends in Biochemical Sciences 29 265 273
38. H Yamashita P ten Dijke P Franzen K Miyazono CH Heldin 1994 Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta Journal of Biological Chemistry 269 20172 20178
39. M Guerrero-Esteo T Sanchez-Elsner A Letamendia C Bernabeu 2002 Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II Journal of Biological Chemistry 277 32 29197 29209