Preclinical pharmacology of sugammadex

Journal of Critical Care

Volumn 24, Issue 1, 2009, Pages 29-35

  Bom, Anton ^a   Hope, Frank ^a   Rutherford, Samantha ^a   Thomson, Karen ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Reversal; Rocuronium; Sugammadex; Vecuronium

Indexed keywords

ACETYLCHOLINE; ATRACURIUM; CHLORALOSE; MAGNESIUM; MIVACURIUM; ROCURONIUM; SUGAMMADEX; SUXAMETHONIUM; URETHAN; VECURONIUM;

DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HEMIDIAPHRAGM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROMUSCULAR BLOCKING; NONHUMAN; PHRENIC NERVE; PROTEIN SECRETION; REVIEW; UNSPECIFIED SIDE EFFECT;

ANDROSTANOLS; ANESTHESIA RECOVERY PERIOD; ANIMALS; CALORIMETRY; CHEMISTRY, PHARMACEUTICAL; CHOLINESTERASE INHIBITORS; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; GAMMA-CYCLODEXTRINS; METABOLIC CLEARANCE RATE; MICE; NEUROMUSCULAR BLOCKADE; NEUROMUSCULAR JUNCTION; NEUROMUSCULAR NONDEPOLARIZING AGENTS; SAFETY; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TITRIMETRY; VECURONIUM BROMIDE;

EID: 61449259923     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2008.10.010     Document Type: Review

References (17)

1. Bom A., Bradley M., Cameron K., et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 41 2 (2002) 266-270
2. Adam J.M., Bennett D.J., Bom A., et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. J Med Chem 45 9 (2002) 1806-1816
3. Tarver G.J., Grove S.J., Buchanan K., et al. 2-O-substituted cyclodextrins as reversal agents for the neuromuscular blocker rocuronium bromide. Bioorg Med Chem 10 6 (2002) 1819-1827
4. Cameron K.S., Clark J.K., Cooper A., et al. Modified gamma-cyclodextrins and their rocuronium complexes. Org Lett 4 20 (2002) 3403-3406
5. 2 subunits contribute to tetanic fade in the rat isolated diaphragm. Synapse 49 2 (2003) 77-88
6. Jonsson M., Gurley D., Dabrowski M., et al. Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology 105 3 (2006) 521-533
7. Epemolu O., Bom A., Hope F., et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969. Anesthesiology 99 3 (2003) 632-637
8. Bom A., van Egmond J., Hope F., et al. Rapid reversal of rocuronium-induced neuromuscular block by Org 25969 is independent of renal perfusion (2003). www.asa-abstracts.com [A-1158, abstr]
9. Bom A., and Mason R. Rapid reversal of profound neuromuscular block by the novel reversal agent Org 25969. Eur J Anesthesiol 19 Suppl 24 (2002) A-426 [abstr]
10. Bom A., and Mason R. McIndewar I. Org 25969 causes rapid reversal of rocuronium-induced neuromuscular block, independent of acid-base status (2002). www.asa-abstracts.com [A-1009, abstr]
11. Bom A., and Hope F. A higher than required dose of sugammadex prevents the creation of a situation similar to "priming" (2007). www.asa-abstracts.com
12. Bom A., and Hope F. Sugammadex (Org 25969) can prevent neomycin-induced re-occurrence of neuromuscular block in guinea pigs. Anesth Analg 102 (2006) S-270 [abstr]
13. Hope F., and Bom A. Org 25969 reverses rocuronium-induced neuromuscular blockade in the cat without important haemodynamic effects. Eur J Anesthesiol 18 Suppl 23 (2001) 17 [abstr]
14. de Boer H.D., van Egmond J., van de Pol F., et al. Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation. Br J Anaesth 97 5 (2006) 681-686
15. de Boer H.D., van Egmond J., van de Pol F., et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology 104 4 (2006) 718-723
16. de Boer H.D., van Egmond J., van de Pol F., et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth 96 4 (2006) 473-479
17. de Boer H.D., van Egmond J., van de Pol F., et al. Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys. Br J Anaesth 96 2 (2006) 201-206