Solution structure and catalytic mechanism of human protein histidine phosphatase 1

Biochemical Journal

Volumn 418, Issue 2, 2009, Pages 337-344

  Gong, Weibin ^a   Li, Yifei ^a   Cui, Gaofeng ^a,b   Hu, Jicheng ^a   Fang, Huaming ^a   Jin, Changwen ^a,b   Xia, Bin ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Active site; Catalytic mechanism; Phosphatase; Phosphohistidine; Vertebrate

Indexed keywords

ACTIVE SITE; CATALYTIC MECHANISM; PHOSPHATASE; PHOSPHOHISTIDINE; VERTEBRATE;

BINDING ENERGY; QUANTUM CHEMISTRY; SIGNAL TRANSDUCTION;

BINDING SITES;

ALANINE; HISTIDINE; HISTIDINE PHOSPHATASE 1; IMIDAZOLE; LYSINE; NUCLEOPHILE; PHOSPHOPROTEIN PHOSPHATASE; SERINE; UNCLASSIFIED DRUG; WATER; PHOSPHATASE; PHOSPHATE; PHPT1 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA HELIX; ENZYMATIC ASSAY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN STRUCTURE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; SOLUTION AND SOLUBILITY; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; VERTEBRATA;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; SOLUTIONS; SUBSTRATE SPECIFICITY;

EID: 61449218994     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081571     Document Type: Article

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