Correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadias

International Journal of Environmental Research and Public Health

Volumn 6, Issue 2, 2009, Pages 568-578

  Giannandrea, Fabrizio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cocoa consumption; Hypospadias; Male reproductive diseases; Testicular cancer

Indexed keywords

ADULT; ARTICLE; CACAO; CANCER INCIDENCE; CANCER REGISTRY; CORRELATION ANALYSIS; FOOD INTAKE; HUMAN; HYPOSPADIAS; MALE; PREGNANCY; PRENATAL EXPOSURE; PRENATAL PERIOD; PREVALENCE; TESTIS CANCER;

ANIMALIA; THEOBROMA CACAO;

EID: 61449182765     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph6020578     Document Type: Article

References (29)

1. Huyghe, E.; Matsuda, T.; Thonneau, P. Increasing incidence of testicular cancer worldwide: a review. J. Urol. 2003, 770, 5-11.
2. Purdue, M.P.; Devesa, S.S.; Sigurdson, A.J.; McGlynn, K.A. International patterns and trends in testis cancer incidence. Int. J. Cancer 2005, 775, 822-827.
3. Bray, F.; Richiardi, L.; Ekbom, A.; Pukkala, E.; Cuninkova, M.; Møller, H. Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality. Int. J. Cancer 2006, 775, 3099-3111.
4. Sharpe, R.M.; Skakkebaek, N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Int. J. Androl. 2006, 29, 211-218.
5. Virtanen, H.E.; Rajpert-De Meyts, E.; Main, K.M.; Skakkebaek, N.E.; Toppari, J. Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders. Toxicol. Appl. Pharmacol. 2005, 207, 501-505.
6. Dieckmann, K.P.; Pichlmeier, U. Clinical epidemiology of testicular germ cell tumors. World. J. Urol. 2004, 22, 2-14.
7. Almstrup, K.; Sonne, S.B.; Hoei-Hansen, C.E.; Ottesen, A.M.; Nielsen, J.E.; Skakkebaek, N.E.; Leffers, H.; Rajpert-De Meyts, E. From embryonic stem cells to testicular germ cell cancer-should we be concerned? Int. J. Androl. 2006, 29, 211-218.
8. Burlingame, B. Trends in foods available for consumption: Europe, 1961-1999. IARC Sci. Publ. 2002, 756, 513-517.
9. FAOSTAT Database. Available at: http://faostat.fao.org/site/502/ DesktopDefault.aspx (accessed December 30, 2008).
10. International Agency for Research on Cancer (IARC). Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 27 February to 6 March 1990. IARC Monogr. Eval. Carcinog. Risks Hum. 1991, 51, 1-513
11. Wang, Y.; Waller, D.P.; Hikim, A.P.; Russell, L.D. Reproductive toxicity of theobromine and cocoa extract in male rats. Reprod. Toxicol. 1992, 6, 347-353.
12. Weinberger, M.A.; Friedman, L; Farber, T.M.; Moreland, F.M.; Peters, E.L., Gilmore, C.E., Khan, M.A. Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline. J. Environ. Pathol. Toxicol. 1978, 1, 669-688.
13. Tarka, S.M.; Zoumas, B.L.; Gans, J.H. Effects of continuous administration of dietary theobromine on rat testicular weight and morphology. Toxicol. Appl. Pharmacol. 1981, 55, 76-82.
14. Renner, H.W.; Münzner, R. Genotoxicity of cocoa examined by microbial and mammalian systems. Mutat. Res. 1982, 103, 275-281.
15. Patera, J.; Chorostowska-Wynimko, J.; Słodkowska, J.; Borowska, A.; Skopiński, P.; Sommer, E.; Wasiutyński, A.; Skopińska-Rózewska, E. Morphometric and functional abnormalities of kidneys in the progeny of mice fed chocolate during pregnancy and lactation. Folia Histochem. Cytobiol. 2006, 44, 207-211.
16. International Agency for Research on Cancer (IARC). Cancer Incidence in Five Continents. Vol. IX. Available at: http://www-dep.iarc.fr (accessed December 30, 2008).
17. International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS). Annual Report 2005 with data for 2003. Avaiable from: http://www.icbdsr.org/filebank/documents/Report2005.pdf (accessed December 30, 2008).
18. Toppari, J.; Kaleva, M.; Virtanen, H.E. Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data. Hum. Reprod. Update 2001, 7, 282-286.
19. Paulozzi, L. Effects of age of diagnosis and latency on the correlation of testicular cancer incidence with fat consumption. Int. J. Cancer 1998, 78, 527-528.
20. Friedman, L; Weinberger, M.A.; Farber T.M.; Moreland, F.M.; Peters, E.L.; Gilmore, C.E.; Khan, M.A. Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline. J. Environ. Pathol. Toxicol. 1979, 2, 687-706.
21. Funabashi, H.; Fujioka, M.; Kohchi, M.; Tateishi, Y.; Matsuoka, N. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 22). Effects of 2- and 4-week administration of theobromine on the testis. J. Toxicol. Sci. 2000, Spec No, 211-221
22. Resman, B.H.; Blumenthal, P.; Jusko, W.J. Breast milk distribution of theobromine from chocolate. J. Pediatr. 1977, 91, 477-480.
23. European Food Safety Authority (EFSA). Theobromine as undesirable substances in animal feed. Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J. 2008, 725, 1-66
24. Giannandrea, F.; Talamanca, I.F. Increased availability of estrogens to the foetus and the risk of testicular cancer in later life: does insulin have a role? Med. Hypotheses 2008, 71, 152-153.
25. Brand-Miller, J.; Holt, S.H.; de Jong, V.; Petocz, P. Cocoa powder increases postprandial insulinemia in lean young adults. J. Nutr. 2003, 133, 3149-3152.
26. Fung, T.T.; Hu, F.B.; Barbieri, R.L.; Willett, W.C.; Hankinson, S.E. Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women. Int. J. Cancer. 2007, 727, 803-809.
27. Lagiou, P.; Lagiou, A.; Samoli, E.; Hsieh, C.C.; Adami, H.O.; Trichopoulos D. Diet during pregnancy and levels of maternal pregnancy hormones in relation to the risk of breast cancer in the offspring. Eur. J. Cancer Prev. 2006, 75, 20-26.
28. Amézqueta, S.; González-Peñas, E.; Murillo, M.; de Cerain, A.L.Occurrence of ochratoxin A in cocoa beans: effect of shelling. Food Addit. Contam. 2005, 22, 590-596.
29. Schwartz, G.G. Hypothesis: does ochratoxin A cause testicular cancer? Cancer Causes Control 2002, 73, 91-100.