Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. 22) Effects of 2- and 4-week administration of theobromine on the testis

Journal of Toxicological Sciences

Volumn 25, Issue SPEC. ISS, 2000, Pages 211-221

  Funabashi, H ^a   Fujioka, M ^a   Kohchi, M ^a   Tateishi, Y ^a   Matsuoka, N ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Histopathology; Male rats; Testicular toxicity; Theobromine

Indexed keywords

THEOBROMINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DEGENERATION; CELL VACUOLE; CONTROLLED STUDY; DESQUAMATION; GIANT CELL; HISTOPATHOLOGY; MALE; MALE GENITAL SYSTEM; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SPERMATID; SPERMATOCYTE; TESTIS WEIGHT; TOXICITY TESTING;

ANIMALIA;

EID: 0033660212     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.specialissue_211     Document Type: Article

References (12)

1. Retardation of spermiation following short-term treatment of rats with theobromine
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3. Comparative toxicities of dietary caffeine and theobromine in the rat
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5. Daily sperm production and epididymal sperm reserves of pubertal and adult rats
6. A collaborative study in Japan on optimal treatment period and parameters for detection of mate fertility disorders induced by drugs in rats
7. Studies on the optimal treatment period and parameters for detection of male fertility disorder in rats
8. Short-term effects of graded levels of theobromine in laboratory rodents
9. Effects of continuous administration of dietary theobromine on rat testicular weight and morphology
10. Reproductive toxicity of theobromine and cocoa extract in male rats
11. Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline