Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function

Angiogenesis

Volumn 12, Issue 1, 2009, Pages 35-46

  McGonigle, Joseph S ^a,b   Giachelli, Cecilia M ^a   Scatena, Marta ^a  

^a University of Washington   (United States)

^b SurModics Inc   (United States)

Author keywords

Apoptosis; ERK signaling; Neovessels formation; Proliferation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR RECEPTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; AORTA; APOPTOSIS; CELL PROLIFERATION; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOPROTEGERIN; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; RATS; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

RATTUS;

EID: 61449157230     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-008-9127-z     Document Type: Article

References (51)

1. G Gasparini R Longo M Toi N Ferrara 2005 Angiogenic inhibitors: a new therapeutic strategy in oncology Nat Clin Pract Oncol 2 562 577 10.1038/ncponc0342
2. BH Annex M Simons 2005 Growth factor-induced therapeutic angiogenesis in the heart: protein therapy Cardiovasc Res 65 649 655 10.1016/j.cardiores.2004. 09.004
3. ZS Patel AG Mikos 2004 Angiogenesis with biomaterial-based drug- and cell-delivery systems J Biomater Sci Polym Ed 15 701 726 10.1163/ 156856204774196117
4. BD Ratner 2002 Reducing capsular thickness and enhancing angiogenesis around implant drug release systems J Control Release 78 211 218 10.1016/S0168-3659(01)00502-8
5. WS Simonet DL Lacey CR Dunstan M Kelley MS Chang R Luthy HQ Nguyen S Wooden L Bennett T Boone 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 309 319 10.1016/S0092-8674(00)80209-3
6. E Tsuda M Goto S Mochizuki K Yano F Kobayashi T Morinaga K Higashio 1997 Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis Biochem Biophys Res Commun 234 137 142 10.1006/bbrc.1997.6603
7. LC Hofbauer 1999 Osteoprotegerin ligand and osteoprotegerin: novel implications for osteoclast biology and bone metabolism Eur J Endocrinol 141 195 210 10.1530/eje.0.1410195
8. LC Hofbauer S Khosla CR Dunstan DL Lacey WJ Boyle BL Riggs 2000 The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption J Bone Miner Res 15 2 12 10.1359/jbmr.2000.15.1.2
9. DL Lacey E Timms HL Tan MJ Kelley CR Dunstan T Burgess R Elliott A Colombero G Elliott S Scully 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 165 176 10.1016/S0092-8674(00)81569-X
10. BR Wong J Rho J Arron E Robinson J Orlinick M Chao S Kalachikov E Cayani FS Bartlett 3rd WN Frankel 1997 TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells J Biol Chem 272 25190 25194 10.1074/jbc.272.40.25190
11. DM Anderson E Maraskovsky WL Billingsley WC Dougall ME Tometsko ER Roux MC Teepe RF DuBose D Cosman L Galibert 1997 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Nature 390 175 179 10.1038/36593
12. K Abe A Kurakin M Mohseni-Maybodi B Kay R Khosravi-Far 2000 The complexity of TNF-related apoptosis-inducing ligand Ann N Y Acad Sci 926 52 63
13. JG Emery P McDonnell MB Burke KC Deen S Lyn C Silverman E Dul ER Appelbaum C Eichman R DiPrinzio 1998 Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL J Biol Chem 273 14363 14367 10.1074/jbc.273.23.14363
14. TJ Yun PM Chaudhary GL Shu JK Frazer MK Ewings SM Schwartz V Pascual LE Hood EA Clark 1998 OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40 J Immunol 161 6113 6121
15. H Yasuda N Shima N Nakagawa K Yamaguchi M Kinosaki S Mochizuki A Tomoyasu K Yano M Goto A Murakami 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Proc Natl Acad Sci USA 95 3597 3602 10.1073/pnas.95.7.3597
16. N Bucay I Sarosi CR Dunstan S Morony J Tarpley C Capparelli S Scully HL Tan W Xu DL Lacey 1998 Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Genes Dev 12 1260 1268 10.1101/gad.12.9.1260
17. A Mizuno N Amizuka K Irie A Murakami N Fujise T Kanno Y Sato N Nakagawa H Yasuda S Mochizuki 1998 Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin Biochem Biophys Res Commun 247 610 615 10.1006/bbrc.1998.8697
18. YY Kong H Yoshida I Sarosi HL Tan E Timms C Capparelli S Morony AJ Oliveira-dos-Santos G Van A Itie 1999 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature 397 315 323 10.1038/16852
19. WC Dougall M Glaccum K Charrier K Rohrbach K Brasel T De Smedt E Daro J Smith ME Tometsko CR Maliszewski 1999 RANK is essential for osteoclast and lymph node development Genes Dev 13 2412 2424 10.1101/gad.13.18.2412
20. AC Zannettino CA Holding P Diamond GJ Atkins P Kostakis A Farrugia J Gamble LB To DM Findlay DR Haynes 2005 Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor J Cell Physiol 204 714 723 10.1002/jcp.20354
21. BJ Bennett M Scatena EA Kirk M Rattazzi RM Varon M Averill SM Schwartz CM Giachelli ME Rosenfeld 2006 Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice Arterioscler Thromb Vasc Biol 26 2117 2124 10.1161/01.ATV.0000236428.91125.e6
22. S Morony Y Tintut Z Zhang RC Cattley G Van D Dwyer M Stolina PJ Kostenuik LL Demer 2008 Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice Circulation 117 411 420 10.1161/ CIRCULATIONAHA.107.707380
23. S Kiechl G Schett G Wenning K Redlich M Oberhollenzer A Mayr P Santer J Smolen W Poewe J Willeit 2004 Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease Circulation 109 2175 2180 10.1161/01.CIR.0000127957.43874.BB
24. M Schoppet AM Sattler JR Schaefer LC Hofbauer 2006 Osteoprotegerin (OPG) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in atherosclerosis Atherosclerosis 184 446 447 10.1016/j.atherosclerosis.2005.10. 028
25. M Soufi M Schoppet AM Sattler M Herzum B Maisch LC Hofbauer JR Schaefer 2004 Osteoprotegerin gene polymorphisms in men with coronary artery disease J Clin Endocrinol Metab 89 3764 3768 10.1210/jc.2003-032054
26. S Ziegler S Kudlacek A Luger E Minar 2005 Osteoprotegerin plasma concentrations correlate with severity of peripheral artery disease Atherosclerosis 182 175 180
27. UM Malyankar M Scatena KL Suchland TJ Yun EA Clark CM Giachelli 2000 Osteoprotegerin is an alpha vbeta 3-induced, NF-kappa B-dependent survival factor for endothelial cells J Biol Chem 275 20959 20962 10.1074/jbc.C000290200
28. M Scatena C Giachelli 2002 The alpha(v)beta3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway. Potential role in angiogenesis Trends Cardiovasc Med 12 83 88 10.1016/S1050-1738(01)00151-7
29. LB Pritzker M Scatena CM Giachelli 2004 The role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand in human microvascular endothelial cell survival Mol Biol Cell 15 2834 2841 10.1091/mbc.E04-01-0059
30. DE Myers FM Collier C Minkin H Wang WR Holloway M Malakellis GC Nicholson 1999 Expression of functional RANK on mature rat and human osteoclasts FEBS Lett 463 295 300 10.1016/S0014-5793(99)01650-6
31. WH Zhu RF Nicosia 2002 The thin prep rat aortic ring assay: a modified method for the characterization of angiogenesis in whole mounts Angiogenesis 5 81 86 10.1023/A:1021509004829
32. WH Zhu A MacIntyre RF Nicosia 2002 Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting Am J Pathol 161 823 830
33. SS Cross Z Yang NJ Brown SP Balasubramanian CA Evans JK Woodward HL Neville-Webbe JM Lippitt MW Reed RE Coleman 2006 Osteoprotegerin (OPG)-a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int J Cancer 118 1901 1908 10.1002/ijc.21606
34. AC Bharti BB Aggarwal 2004 Ranking the role of RANK ligand in apoptosis Apoptosis 9 677 690 10.1023/B:APPT.0000045780.10463.c6
35. AC Bharti Y Takada S Shishodia BB Aggarwal 2004 Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism J Biol Chem 279 6065 6076 10.1074/jbc.M308062200
36. HH Kim HS Shin HJ Kwak KY Ahn JH Kim HJ Lee MS Lee ZH Lee GY Koh 2003 RANKL regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway FASEB J 17 2163 2165
37. YM Kim YM Lee HS Kim JD Kim Y Choi KW Kim SY Lee YG Kwon 2002 TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cells J Biol Chem 277 6799 6805 10.1074/jbc.M109434200
38. SJ Alladina JH Song ST Davidge C Hao AS Easton 2005 TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2 J Vasc Res 42 337 347 10.1159/000086599
39. G Cantarella N Risuglia R Dell'eva L Lempereur A Albini G Pennisi GM Scoto DN Noonan R Bernardini 2006 TRAIL inhibits angiogenesis stimulated by VEGF expression in human glioblastoma cells Br J Cancer 94 1428 1435 10.1038/sj.bjc.6603092
40. JH Li NC Kirkiles-Smith JM McNiff JS Pober 2003 TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells J Immunol 171 1526 1533
41. P Secchiero A Gonelli E Carnevale F Corallini C Rizzardi S Zacchigna M Melato G Zauli 2004 Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand Neoplasia 6 364 373 10.1593/neo.03421
42. P Secchiero A Gonelli E Carnevale D Milani A Pandolfi D Zella G Zauli 2003 TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways Circulation 107 2250 2256 10.1161/01.CIR.0000062702.60708.C4
43. R Auerbach R Lewis B Shinners L Kubai N Akhtar 2003 Angiogenesis assays: a critical overview Clin Chem 49 32 40 10.1373/49.1.32
44. RF Nicosia YJ Lin D Hazelton X Qian 1997 Endogenous regulation of angiogenesis in the rat aorta model. Role of vascular endothelial growth factor Am J Pathol 151 1379 1386
45. S Villaschi RF Nicosia 1993 Angiogenic role of endogenous basic fibroblast growth factor released by rat aorta after injury Am J Pathol 143 181 190
46. G Ferrari G Pintucci G Seghezzi K Hyman AC Galloway P Mignatti 2006 VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis Proc Natl Acad Sci USA 103 17260 17265 10.1073/pnas.0605556103
47. I Segura A Serrano GG De Buitrago MA Gonzalez JL Abad C Claveria L Gomez A Bernad AC Martinez HH Riese 2002 Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis FASEB J 16 833 841 10.1096/fj.01-0819com
48. W Fierlbeck A Liu R Coyle BJ Ballermann 2003 Endothelial cell apoptosis during glomerular capillary lumen formation in vivo J Am Soc Nephrol 14 1349 1354 10.1097/01.ASN.0000061779.70530.06
49. DR Haynes E Barg TN Crotti C Holding H Weedon GJ Atkins A Zannetino MJ Ahern M Coleman PJ Roberts-Thomson 2003 Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls Rheumatology (Oxford) 42 123 134 10.1093/rheumatology/keg047
50. P Collin-Osdoby L Rothe F Anderson M Nelson W Maloney P Osdoby 2001 Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis J Biol Chem 276 20659 20672 10.1074/jbc.M010153200
51. S Jono Y Ikari A Shioi K Mori T Miki K Hara Y Nishizawa 2002 Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease Circulation 106 1192 1194 10.1161/01.CIR.0000031524.49139.29