Mycophenolic acid production in solid-state fermentation using a packed-bed bioreactor

Biochemical Engineering Journal

Volumn 44, Issue 2-3, 2009, Pages 106-110

  Alani, Faiez ^a   Grove, Jason A ^b   Anderson, William A ^b   Moo Young, Murray ^b  

^a BRANDON UNIVERSITY   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Mycophenolic acid; Packed bed bioreactor; Pearl barley; Penicillium brevicompactum; Solid state fermentation

Indexed keywords

MYCOPHENOLIC ACID; PACKED-BED BIOREACTOR; PEARL BARLEY; PENICILLIUM BREVICOMPACTUM; SOLID-STATE FERMENTATION;

ACIDS; BIOCHEMICAL ENGINEERING; BIOCONVERSION; BIOREACTORS; ELECTRON HOLOGRAPHY; GEMS; INDUSTRIAL CHEMICALS;

FERMENTATION;

MANNITOL; MYCOPHENOLIC ACID;

ARTICLE; BARLEY; CONTROLLED STUDY; CULTURE OPTIMIZATION; FERMENTATION; MOISTURE; NONHUMAN; OAT; PACKED BED REACTOR; PENICILLIUM; PENICILLIUM BREVICOMPACTUM; PH; PRIORITY JOURNAL; RICE; SOLID STATE; WHEAT BRAN;

HORDEUM; PENICILLIUM BREVICOMPACTUM; TRITICUM AESTIVUM;

EID: 61449155512     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2008.11.005     Document Type: Article

References (12)

1. Vinokurova N., Ivanushkina N., Kochkina G., Arinbasarov M., and Ozerskaya S. Production of mycophenolic acid by fungi of genus Penicillium link. Appl. Biochem. Microbiol. 41 (2005) 83-86
2. Bentley R. Mycophenolic acid: a one hundred year odyssey from antibiotic to immunosuppressant. Chem. Rev. 100 (2000) 3801-3825
3. Wirsching S., Morgan G., Sullivan D., Coleman D., and Morschhauser J. Antimicrob. Agents Chemother. 45 (2001) 3416-3421
4. Holker U., Hofer M., and Lenz J. Biotechnological advantages of laboratory-scale solid-state fermentation with fungi. Appl. Microbiol. Biotechnol. 64 (2004) 175-186
5. Ozaki H., Kubota K., and Takahashi H. Effects various adsorbents on mycelium formation and mycophenolic acid production by Penicillium brevicompactum. Agric. Biol. Chem. 51 (1987) 2503-2508
6. Sadhukhan A.K., Murphy M.V., Kumar R., Mohan E., Vandana G., Bahr C., and Rao K. Optimization of mycophenolic acid production in solid state fermentation using response surface methodology. J. Ind. Microbiol. Biotechnol. 22 (1999) 33-38
7. Xu Z., and Yang S. Production of mycophenolic acid by Penicillium brevicompactum immobilized in a rotating fibrous-bed bioreactor. Enzyme Microb. Technol. 40 (2007) 623-628
8. Barrios-Gonzalez J., Castillo T.E., and Mejia A. Development of high penicillin producing strains for solid-state fermentations. Biotechnol. Adv. 11 (1993) 525-537
9. Tomasini A., Fajardo C., and Barrios-Gonzalez J. Giberellic acid production using different solid state fermentation systems. World J. Microbiol. Biotechnol. 13 (1997) 203-206
10. Harris J.P., and Mantel P.G. Biosynthesis of ochratoxins by Aspergillus ochraceus. Phytochemistry 58 (2001) 709-716
11. Sekar C., Rajasekar V., and Balaraman K. Production of cyclosporin A by solid-state fermentation. Bioproc. Eng. 17 (1997) 257-259
12. Krishna C. Solid-state fermentation systems-an overview. Crit. Rev. Biotechnol. 25 (2005) 1-30