A validated LC/MS/MS method for the quantification of pyrrole-2,3,5- tricarboxylic acid (PTCA), a eumelanin specific biomarker, in human skin punch biopsies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 826, Issue 1-2, 2005, Pages 31-40

  Szekely Klepser, Gabriella ^a   Wade, Kimberly ^a   Woolson, Dayna ^a   Brown, Richard ^a   Fountain, Scott ^a   Kindt, Erick ^a  

^a PFIZER INC   (United States)

Author keywords

Biomarker; Eumelanin; Human skin; LC MS MS; Mass spectrometry; Melanin; Pigmentation; PTCA; Pyrrole 2,3,5 tricarboxylic acid

Indexed keywords

BIOASSAY; BIOMEDICAL ENGINEERING; BIOPSY; CARBOXYLIC ACIDS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PIGMENTS; SKIN; TISSUE;

EUMELANIN; HUMAN SKIN; LC/MS/MS; MELANIN; PIGMENTATION; PTCA; PYRROLE-2,3,5-TRICARBOXYLIC ACID;

BIOMARKERS;

BIOLOGICAL MARKER; MELANIN; PYRROLE 2,3,5 TRICARBOXYLIC ACID; PYRROLE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; OXIDATION; PRIORITY JOURNAL; PUNCH BIOPSY; QUALITY CONTROL; SENSITIVITY ANALYSIS; SKIN BIOPSY; SKIN PIGMENTATION; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

AFRICAN AMERICANS; ANIMALS; BIOLOGICAL MARKERS; BIOPSY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; MASS SPECTROMETRY; MELANINS; MICE; PYRROLES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SKIN; SKIN PIGMENTATION;

EID: 26844532543     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.08.002     Document Type: Article

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