Properties of an oral preparation containing a chitosan salt

Molecules

Volumn 14, Issue 2, 2009, Pages 755-762

  Murata, Yoshifumi ^a   Kodama, Youko ^a   Hirai, Daijirou ^a   Kofuji, Kyouko ^a   Kawashima, Susumu ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

Bile acid adsorption; Chitosan, 2 (4 Chlorophenoxy) 2 methylpropionic acid; Drug release; Hyperlipidemia

Indexed keywords

ALGINIC ACID; BILE ACID; CHITOSAN; CHOLESTEROL; GLUCURONIC ACID; HEXURONIC ACID; INORGANIC SALT; PROPIONIC ACID DERIVATIVE; TRIACYLGLYCEROL;

ADSORPTION; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DIET; EATING; HUMAN; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RAT; STATIC ELECTRICITY; WISTAR RAT;

ADMINISTRATION, ORAL; ADSORPTION; ALGINATES; ANIMALS; BILE ACIDS AND SALTS; CHITOSAN; CHOLESTEROL; DIET; EATING; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MALE; MOLECULAR STRUCTURE; PROPIONIC ACIDS; RATS; RATS, WISTAR; SALTS; STATIC ELECTRICITY; TRIGLYCERIDES;

EID: 61449097534     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14020755     Document Type: Article

References (13)

1. Gao, Y.; Oshita, K.; Lee, K.H.; Oshima, M.; Motomizu, S. Development of column-pretreatment chelating resins for matrix elimination/multi-element determination by inductively coupled plasma-mass spectrometry. Analyst 2002, 127, 1713-1719.
2. Terashima, M.; Oka, N.; Sci, T.; Yoshida, H. Adsorption of cadmium ion and gallium ion to immobilized metallothionine fusion protein. Biotechnol. Prog. 2002, 18, 1318-1323.
3. Gallaher, C.M.; Munion, J.; Hesslink, R.Jr.; Wise, J.; Gallaher, D.D. Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid fat excretion in rats. J. Nutr. 2000, 130, 2753-2759.
4. Barroso, A.J.; Contreras, F.; Bagchi, D.; Preuss, H.G. Efficacy of a novel chitosan formulation on fecal fat excretion: a double-blind, crossover, placebo-controlled study. J. Med. 2002, 33, 209-225.
5. Ylitalo, R.; Lehtinen, S.; Wuolijoki, E.; Ylitalo, P.; Lehtimaki, T. Cholesterol-lowering properties and safety of chitosan. Arzneimittelforschung 2002, 52, 1-7.
6. Shields, K.M.; Smock, N.; McQueen, C.E.; Bryant, P.J. Chitosan for weight loss and cholesterol management. Am. J. Health Syst. Pharm. 2003, 60, 1310-1312.
7. Homma, Y.; Kobayashi, T.; Yamaguchi, H.; Ozawa, H.; Sakane, H.; Nakamura, H. Specific reduction of plasma large, light low-density lipoprotein by a bile acid sequestering resin, cholebine (MCI-196) in type II hyperlipoproteinemia. Atherosclerosis 1997, 21, 241-248.
8. Manhas, A.; Farmer, J.A. Hypolipidemic therapy and cholesterol absorption. Curr. Atheroscler Rep. 2004, 6, 89-93.
9. Wierzbicki, A.S.; Mikhailidis, D.P.; Wray, R. Drug treatment of combined hyperlipidemia. Am. J. Cardiovasc. Drugs 2001, 1, 327-336.
10. Alzahrani, T.; Marrat, S.; Haider, A. Management of dyslipidemia in primary care. Can. J. Cardiol. 2004, 19, 1499-1502.
11. Murata, Y.; Toniwa, S.; Miyamoto, E.; Kawashima, S. Preparation of alginate gel beads containing chitosan nicotinic acid salt and the functions. Euro. J. Pharm. Biopharm. 1999, 48, 49-52.
12. Murata, Y.; Kojima, N.; Kawashima, S. Functions of a chitosan-orotic acid salt in the gastrointestinal tract, Biol. Pharm. Bull. 2003, 26, 687-690.
13. Murata, Y.; Jinno, D.; Liu, D.; Isobe, T.; Kofuji, K.; Kawashima, S. The drug release profile from calcium-induced alginate gel beads coated with an alginate hydrolysate. Molecules 2007, 12, 2559-2566.