Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology

Nature Protocols

Volumn 4, Issue 1, 2009, Pages 86-93

  Krupnick, Alexander S ^a,b   Lin, Xue ^a   Li, Wenjun ^a   Okazaki, Mikio ^a   Lai, Jiaming ^a   Sugimoto, Seiichiro ^a   Richardson, Steven B ^a   Kornfeld, Christopher G ^a   Garbow, Joel R ^b,c   Patterson, Alexander G ^a,b   Gelman, Andrew E ^a   Kreisel, Daniel ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Washington University in St Louis School of Medicine   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGRAFT; ANASTOMOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL SHUNT; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL ANIMAL; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC CELL; IMMUNOBIOLOGY; LUNG TRANSPLANTATION; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; OPERATION DURATION; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; SURGICAL TECHNIQUE; SURGICAL TRAINING; SURVIVAL RATE; VASCULARIZATION; ANIMAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LUNG; METHODOLOGY;

ANIMALS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LUNG; LUNG TRANSPLANTATION; MICE; MODELS, ANIMAL;

EID: 61449095643     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2008.218     Document Type: Article

References (23)

1. Trulock, E.P. et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult lung and heart-lung transplantation report-2007. J. Heart Lung Transplant. 26, 782-795 (2007).
2. Truong, W., Emamaullee, J.A., Merani, S., Anderson, C.C. & James Shapiro, A.M. Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. Am. J. Transplant. 7, 2031-2038 (2007).
3. Hertz, M.I., Jessurun, J., King, M.B., Savik, S.K. & Murray, J.J. Reproduction of the obliterative bronchiolitis lesion after heterotopic transplantation of mouse airways. Am. J. Pathol. 142, 1945-1951 (1993).
4. Belperio, J.A. et al. Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J. Clin. Invest. 115, 1150-1162 (2005).
5. Belperio, J.A. et al. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J. Clin. Invest. 108, 547-556 (2001).
6. Djamali, A. & Odorico, J.S. Fas-mediated cytotoxicity is not required for rejection of murine nonvascularized heterotopic cardiac allografts. Transplantation 66, 1793-1801 (1998).
7. Neuringer, I.P. et al. Epithelial kinetics in mouse heterotopic tracheal allografts. Am. J. Transplant. 2, 410-419 (2002).
8. Okazaki, M. et al. Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplants. Am. J. Respir. Cell Mol. Biol. 37, 625-630 (2007).
9. Khalifah, A.P. et al. Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. Am. J. Respir. Crit. Care Med. 170, 181-187 (2004).
10. D'Ovidio, F. et al. The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am. J. Transplant. 6, 1930-1938 (2006).
11. Iacono, A.T. et al. A randomized trial of inhaled cyclosporine in lung-transplant recipients. N. Engl. J. Med. 354, 141-150 (2006).
12. Okazaki, M. et al. Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. Am. J. Transplant. 7, 751-758 (2007).
13. Mizuta, T., Kawaguchi, A., Nakahara, K. & Kawashima, Y. Simplified rat lung transplantation using a cuff technique. J. Thorac. Cardiovasc. Surg. 97, 578-581 (1989).
14. Okazaki, M. et al. A mouse model of orthotopic vascularized aerated lung transplantation. Am. J. Transplant. 7, 1672-1679 (2007).
15. Gelman, A.E. et al. CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants. J. Immunol. 180, 4754-4762 (2008).
16. Krieger, N.R., Yin, D.P. & Fathman, C.G. CD4+ but not CD8+ cells are essential for allorejection. J. Exp. Med. 184, 2013-2018 (1996).
17. Yan, S.F. et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 6, 1355-1361 (2000).
18. Panoskaltsis-Mortari, A., Tram, K.V., Price, A.P., Wendt, C.H. & Blazar, B.R. A new murine model for bronchiolitis obliterans post-bone marrow transplant. Am. J. Respir. Crit. Care Med. 176, 713-723 (2007).
19. Blankenstein, T. The role of tumor stroma in the interaction between tumor and immune system. Curr. Opin. Immunol. 17, 180-186 (2005).
20. Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15-18 (2002).
21. Laufer, T.M., DeKoning, J., Markowitz, J.S., Lo, D. & Glimcher, L.H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81-85 (1996).
22. Liao, Y.-P. et al. Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells. J. Immunol. 173, 2462-2469 (2004).
23. Ganss, R., Ryschich, E., Klar, E., Arnold, B. & Hammerling, G.J. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62, 1462-1470 (2002).