A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice

Proteomics

Volumn 9, Issue 4, 2009, Pages 1044-1056

  Chatterji, Bijon ^a   Borlak, Jürgen ^a,b  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Biomarkers; C myc; Lung cancer; MALDI TOF; Serum; TOF

Indexed keywords

AFAMIN; ALPHA 1 ANTITRYPSIN; ALPHA 2 MACROGLOBULIN; ALPHA ACTIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; AMYLOID P COMPONENT; ANTITHROMBIN III; APOLIPOPROTEIN A1; APOLIPOPROTEIN A4; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; BETA2 GLYCOPROTEIN 1; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; FETUIN A; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 3; OROSOMUCOID; OROSOMUCOID 8; PLASMA PROTEIN; PLASMA RETINOL BINDING PROTEIN; PREALBUMIN; PROPERDIN; PROTEOME; RAF PROTEIN; SERUM ALBUMIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; CONTROLLED STUDY; E BOX ELEMENT; GENE EXPRESSION REGULATION; LUNG CANCER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TUMOR DIFFERENTIATION;

ACUTE-PHASE PROTEINS; ANIMALS; APOLIPOPROTEINS; BIOLOGICAL MARKERS; BLOOD PROTEINS; DISEASE MODELS, ANIMAL; E-BOX ELEMENTS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE PEROXIDASE; LUNG; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; NORMAL DISTRIBUTION; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS C-RAF; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MUS; MUS MUSCULUS;

EID: 61349198132     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200701135     Document Type: Article

References (61)

1. Duarte, R. L., Paschoal, M. E., Molecular markers in lung cancer: Prognostic role and relationship to smoking. J. Bras. Pneumol. 2006, 32, 56-65.
2. Bhattacharjee, A., Richards, W. G., Staunton, J., Li, C. et al., Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl. Acad. Sci. USA 2001, 98, 13790-13795.
3. Takezawa, C., Takahashi, H., Fujishima, T., Shiratori, M. et al., Assessment of differentiation in adenocarcinoma cells from pleural effusion by peripheral airway cell markers and their diagnostic values. Lung Cancer 2002, 38, 273-281.
4. Fields, W. R., Desiderio, J. G., Putnam, K. P., Bombick, D. W., Doolittle, D. J., Quantification of changes in c-myc mRNA levels in normal human bronchial epithelial (NHBE) and lung adenocarcinoma (A549) cells following chemical treatment. Toxicol. Sci. 2001, 63, 107-114.
5. Broers, J. L., Viallet, J., Jensen, S. M., Pass, H. et al., Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of nonsmall cell lung cancers. Am. J. Respir. Cell. Mol. Biol. 1993, 9, 33-43.
6. Little, C. D., Nau, M. M., Carney, D. N., Gazdar, A. F., Minna, J. D., Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 1983, 306, 194-196.
7. Zajac-Kaye, M., Myc oncogene: A key component in cell cycle regulation and its implication for lung cancer. Lung Cancer 2001, 34, S43-S46.
8. Bernasconi, N. L., Wormhoudt, T. A., Laird-Offringa, I. A., Post-transcriptional deregulation of myc genes in lung cancer cell lines. Am. J. Respir. Cell. Mol. Biol. 2000, 23, 560-565.
9. Barr, L. F., Campbell, S. E., Bochner, B. S., Dang, C. V., Association of the decreased expression of alpha3beta1 integrin with the altered cell: Environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells. Cancer Res. 1998, 58, 5537-5545.
10. Lorenz, J., Friedberg, T., Paulus, R., Oesch, F., Ferlinz, R., Oncogene overexpression in nonsmall-cell lung cancer tissue: Prevalence and clinicopathological significance. Clin. Investig. 1994, 72, 156-163.
11. Volm, M., Drings, P., Wodrich, W., van Kaick, G., Expression of oncoproteins in primary human nonsmall cell lung cancer and incidence of metastases. Clin. Exp. Metastasis 1993, 11, 325-329.
12. Pfeifer, A. M., Mark, G. E., III, Malan-Shibley, L., Graziano, S. et al., Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 1989, 86, 10075-10079.
13. Johnson, B. E., Battey, J., Linnoila, I., Becker, K. L. et al., Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. J. Clin. Invest. 1986, 78, 525-532.
14. Volm, M., van Kaick, G., Mattern, J., Analysis of c-fos, c-jun, c-erbB1, c-erbB2 and c-myc in primary lung carcinomas and their lymph node metastases. Clin. Exp. Metastasis 1994, 12, 329-334.
15. Nakashima, T., Liu, D., Nakano, J., Ishikawa, S. et al., Wnt1 overexpression associated with tumor proliferation and a poor prognosis in nonsmall cell lung cancer patients. Oncol. Rep. 2008, 19, 203-209.
16. Ehrhardt, A., Bartels, T., Geick, A., Klocke, R. et al., Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes. Br. J. Cancer 2001, 84, 813-818.
17. Facchini, L. M., Penn, L. Z., The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights. FASEB J 1998, 12, 633-651.
18. Amati, B., Frank, S. R., Donjerkovic, D., Taubert, S., Function of the c-Myc oncoprotein in chromatin remodeling and transcription. Biochim. Biophys. Acta 2001, 1471, 135-145.
19. Lee, L. A., Dang, C. V., Myc target transcriptomes. Curr. Top Microbiol. Immunol. 2006, 302, 145-167.
20. Prochownik, E. V, c-Myc as a therapeutic target in cancer. Expert. Rev. Anticancer Ther. 2004, 4, 289-302.
21. Dang, C. V., c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 1999, 19, 1-11.
22. Ehrhardt, A., Bartels, T., Klocke, R., Paul, D., Halter, R., Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells. J. Cancer Res. Clin. Oncol. 2003, 129, 71-75.
23. Chatterji, B., Borlak, J., Serum proteomics of lung adeno-carcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers. Prote-omics 2007, 7, 3980-3991.
24. Lehner, I., Niehof, M., Borlak, J., An optimized method for the isolation and identification of membrane proteins. Elec-trophoresis 2003, 24, 1795-1808.
25. Rabilloud, T., Use of thiourea to increase the solubility of membrane proteins in two-dimensional electrophoresis. Electrophoresis 1998, 19, 758-760.
26. Görg, A., Postel, W., Weser, J., Günther, S. et al., Elimination of point streaking on silver stained two-dimensional gels by addition of iodoacetamide to the equilibration buffer. Electrophoresis 1987, 8, 122-124.
27. Rütters, H., Zürbig, P., Halter, R., Borlak, J., Towards a lung adenocarcinoma proteome map: Studies with SP-C/c-raf transgenic mice. Proteomics 2006, 6, 3127-3137.
28. Perkins, D. N., Pappin, D. J., Creasy, D. M., Cottrell, J. S., Probability-based protein identification by searching sequence databases using mass spectrometry data. Elec-trophoresis 1999, 20, 3551-3567.
29. Chamrad, D. C., Koerting, G., Gobom, J., Thiele, H. et al., Interpretation of mass spectrometry data for high-throughput proteomics. Anal. Bioanal. Chem. 2003, 376, 1014-1022.
30. Hood, B. L., Zhou, M., Chan, K. C., Lucas, D. A. et al., Investigation of the mouse serum proteome. J. Proteome Res. 2005, 4, 1561-1568.
31. Anderson, N. L., Anderson, N. G., The human plasma pro-teome: History, character, and diagnostic prospects. Mol. Cell. Proteomics 2002, 1, 845-867. Erratum in: Mol. Cell. Proteomics. 2003, 2,50.
32. Zeller, K. I., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., Dang, C. V., An integrated database of genes responsive to the Myc oncogenic transcription factor: Identification of direct genomic targets. Genome. Biol. 2003, 4, R69.
33. Ceciliani, F., Giordano, A., Spagnolo, V., The systemic reaction during inflammation: The acute-phase proteins. Protein Pept. Lett. 2002, 9, 211-223.
34. Kanoh, Y., Ohtani, N., Mashiko, T., Ohtani, S. et al., Levels of alpha 2 macroglobulin can predict bone metastases in prostate cancer. Anticancer Res. 2001, 21, 551-556.
35. Misra, U. K., Pizzo, S. V., Regulation of cytosolic phospholi-pase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: Role in mito-genesis and cell proliferation. J. Biol. Chem. 2002, 277, 4069-4078.
36. Pepys, M. B., Herbert, J., Hutchinson, W. L.,Tennent, G. A. et al., Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 2002, 417, 254-259.
37. Korbelik, M., Cecic, I., Merchant, S., Sun, J., Acute phase response induction by cancer treatment with photodynamic therapy. Int. J. Cancer 2008, 722, 1411-1417.
38. Van Bennekum, A. M., Wei, S., Gamble, M. V., Vogel, S. et al., Biochemical basis for depressed serum retinol levels in transthyretin-deficient mice. J. Biol. Chem. 2001, 276, 1107-1113.
39. Roberts, D., Williams, S. J., Cvetkovic, D., Weinstein, J. K. et al., Decreased expression of retinol-binding proteins is associated with malignant transformation of the ovarian surface epithelium. DNA Cell. Biol. 2002, 21, 11-19.
40. Zhang, Z., Bast, R. C., Jr., Yu, Y., Li, J. et al., Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res. 2004, 64, 5882-5890.
41. Moore, L. E., Fung, E. T., McGuire, M., Rabkin, C. C. et al., Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population. Cancer Epidemiol. Biomarkers Prev. 2006, 15, 1641-1646.
42. Maciel, C. M., Junqueira, M., Paschoal, M. E., Kawamura, M. T. et al., Differential proteomic serum pattern of low molecular weight proteins expressed by adenocarcinoma lung cancer patients. J. Exp. Ther. Oncol. 2005, 5, 31-38.
43. Feng, J. T., Liu, Y. K., Song, H. Y., Dai, Z. et al., Heat-shock protein 27: A potential biomarker for hepatocellular carcinoma identified by serum proteome analysis. Proteomics 2005, 5, 4581-4588.
44. Cham, B, E., Importance of apolipoproteins in lipid metabolism. Chem. Biol. Interact. 1978, 20, 263-277.
45. Chen, J., Anderson, M., Misek, D. E., Simeone, D. M., Lub-man, D. M., Characterization of apolipoprotein and apolipo-protein precursors in pancreatic cancer serum samples via two-dimensional liquid chromatography and mass spec-trometry. J. Chromatogr. A 2007, 1162, 117-25.
46. Venanzoni, M. C., Giunta, S., Muraro, G. B., Storari, L. et al., Apolipoprotein E expression in localized prostate cancers. Int. J. Oncol. 2003, 22, 779-786.
47. Wright, L. C., Sullivan, D. R., Muller, M., Dyne, M. et al., Elevated apolipoprotein(a) levels in cancer patients. Int. J. Cancer 1989, 43, 241-244.
48. Han, C., Zhang, H. T., Du, L., Liu, X. et al., Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine 2005, 26, 19-24.
49. Chang, S. I., El-Bayoumy, K., Sinha, I., Trushin, N. et al.,4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa pro-tein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 228-235.
50. Ishikawa, I., Hayama, T., Yoshida, S., Asaka, M. et al., Proteomic analysis of rat plasma by SELDI-TOF-MS under the condition of prevention of progressive adriamycin nephro-pathy using oral adsorbent AST-120. Nephron. Physiol. 2006, 103, 125-130.
51. Hiukka, A., Fruchart-Najib, J., Leinonen, E., Hilden, H. et al., Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes. Diabetologia 2005, 48, 1207-1215.
52. Yokoyama, Y., Kuramitsu, Y., Takashima, M., Iizuka, N. et al., Protein level of apolipoprotein E increased in human hepa-tocellular carcinoma. Int. J. Oncol. 2006, 28, 625-631.
53. Li, Z. G., Zhao, L., Liu, L., Ding, Y. Q., Monitoring changes of serum protein markers in metastatic colorectal carcinoma model. Zhonghua Bing Li Xue Za Zhi 2007, 36, 48-52.
54. Grønborg, M., Kristiansen, T. Z., Iwahori, A., Chang, R. et al., Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol. Cell. Proteomics 2006, 5, 157-171.
55. Grainger, D. J., Reckless, J., McKilligin, E., Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipo-protein E-deficient mice. J. Immunol. 2004, 173, 6366-6375.
56. Beecken, W. D., Engl, T., Ringel, E. M., Camphausen, K. et al., An endogenous inhibitor of angiogenesis derived from a transitional cell carcinoma: Clipped beta2-glycoprotein-I. Ann. Surg. Oncol. 2006, 13, 1241-1251.
57. Hough, C. D., Cho, K. R., Zonderman, A. B., Schwartz, D. R., Morin, P. J., Coordinately up-regulated genes in ovarian cancer. Cancer Res. 2001, 61, 3869-3876.
58. Iwata, K., Nishinaka, T., Matsuno, K., Yabe-Nishimura, C., Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Biol. Pharm. Bull. 2006, 29, 1042-1045.
59. Smida, J., Holubek, V., Oravec, C., Thurzo, V., The properdin system in tumorous disease. Part VI. Influence of the prop-erdin fraction on the cancerogenic activity of chicken tumour virus B77. Neoplasma 1960, 7, 26-30.
60. Beebe, D. P., Schreiber, R. D., Cooper, N. R., Neutralization of influenza virus by normal human sera: mechanisms involving antibody and complement. J. Immunol. 1983, 130, 1317-1322.
61. Factor, V. M., Kiss, A., Woitach, J. T., Wirth, P. J., Thorgeirs-son, S. S., Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis. J. Biol. Chem. 1998, 273, 15846-15853.