U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line

Journal of Neurochemistry

Volumn 108, Issue 6, 2009, Pages 1526-1538

  Zheng, Chao ^a,b   Wang, Meng Ya ^b   Liu, Qiang ^a   Wakui, Makoto ^c   Whiteaker, Paul ^a   Lukas, Ronald J ^a   Wu, Jie ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b WANNAN MEDICAL COLLEGE   (China)

^c HIROSAKI NATIONAL HOSPITAL   (Japan)

Author keywords

(3 ) 3 2 (diethylamino)ethoxy androst 5 en 17 one dihydrochloride; Nicotinic acetylcholine receptor; Patch clamp; SH EP1 cell line

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CHOLESTEROL; NICOTINE; NICOTINIC RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR ALPHA4BETA2 ANTAGONIST; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENDOCYTOSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; PATCH CLAMP; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING;

ANDROSTENES; ANTICHOLESTEREMIC AGENTS; BIOPHYSICAL PROCESSES; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EPITHELIAL CELLS; GENE EXPRESSION; GUANOSINE DIPHOSPHATE; HUMANS; MEMBRANE POTENTIALS; NICOTINE; PATCH-CLAMP TECHNIQUES; RECEPTORS, NICOTINIC; THIONUCLEOTIDES; TRANS-1,4-BIS(2-CHLOROBENZAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;

EID: 61349196895     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05903.x     Document Type: Article

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