Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb2+) exposure

Toxicology Letters

Volumn 186, Issue 2, 2009, Pages 78-83

  Zhang, Le Feng ^b,c   Peng, Shuang Qing ^a   Wang, Sheng ^b  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

5 HT; Aorta; Hypertension; Lead (Pb2+) toxicity; Structure; Vascular reactivity

Indexed keywords

DRINKING WATER; LEAD; SEROTONIN; SEROTONIN 2B RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; AORTA CONSTRICTION; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; EXPOSURE; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; HYPERTENSION; LEAD; LEAD POISONING; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN;

RATTUS; RATTUS NORVEGICUS;

EID: 61349186309     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.01.004     Document Type: Article

References (39)

1. Assoian R.K., and Marcantonio E.E. The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis. J. Clin. Invest. 100 (1997) S15-S18
2. Banes A.K.L., Florian J.A., and Watts S.W. Mechanisms of 5-hydroxytryptamine(2A) receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle. J. Pharmacol. Exp. Ther. 291 (1999) 1179-1187
3. Banes A.K.L., and Watts S.W. Up-regulation of arterial serotonin-1B and -2B receptors in deoxycorticosterone acetate salt hypertension. Hypertension 39 (2002) 394-398
4. Banes A.K.L., and Watts S.W. Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension. BMC Pharmacol. 3 (2003) 12
5. Courtois E., Marques M., Barrientos A., Casado S., and López-Farré A. Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2. J. Am. Soc. Nephrol. 14 (2003) 1464-1470
6. Cummings S.A., Groszmann R.J., and Kaumann A.J. Hypersensitivity of mesenteric veins to 5-hydroxytryptamine and ketanserin-induced reduction of portal pressure in portal hypertensive rats. Br. J. Pharmacol. 89 (1986) 501-513
7. Ding Y., Gonick FH.C., Vaziri FN.D., Liang K., and Wei L. Lead-induced hypertension. III. Increased hydroxyl radical production. Am. J. Hypertens. 14 2 (2001) 169-173
8. Fenga C., Cacciola A., Martino L.B., Calderaro S.R., Di Nola C., Verzera A., Trimarchi G., and Germano D. Relationship of blood lead levels to blood pressure in exhaust battery storage workers. Ind. Health 44 (2006) 304-309
9. Gohlke P., Lamberty V., Kuwer I., Bartenbach S., Schnell A., and Unger T. Vascular remodeling in systemic hypertension. Am. J. Cardiol. 71 (1993) 2E-7E
10. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., and Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46 (1994) 157-203
11. Institute of Laboratory Animal Resources (U.S.), National Research Council, 1996. Guide for the Care and Use of Laboratory Animals. National Academy of Sciences (USA) Press, Washington, DC.
12. Intengan H.D., and Schiffrin E.L. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38 (2001) 581-587
13. Ito A., Egashira K., Kadokami T., Fukumoto Y., Takayanagi T., Nakaike R., Kuga T., Sueishi K., Shimokawa H., and Takeshita A. Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs. Circulation 92 (1995) 2636-2644
14. Karimi G., Khoshbaten A., Abdollahi M., Sharifzadeh M., Namiranian K., and Dehpour A.R. Effects of subacute lead acetate administration on nitric oxide and cyclooxygenase pathways in rat isolated aortic ring. Pharmacol. Res. 46 (2002) 31-37
15. Kiel J.W., Pitts V., Benoit J.N., Granger D.N., and Shepherd A.P. Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats. Am. J. Physiol. 248 (1985) G192-G195
16. Marques M., Millás I., Jiménez A., García-Collis E., Antonio Rodriguez-Feo J., Velasco S., Barrientos A., Casado S., and López-Farré A. Alterations of the soluble guanylate cyclase system in the vascular wall of lead-induced hypertensive rats. J. Am. Soc. Nephrol. 12 (2001) 2594-2600
17. McGregor D.D., and Smirk F.H. Vascular responses to 5-hydroxytryptamine in genetic and renal hypertensive rats. Am. J. Physiol. 219 (1970) 687-690
18. Menke A., Muntner P., Batuman V., Silbergeld E.K., and Guallar E. Blood lead below 0.48 μmol/L (10 μg/dL) and mortality among US adults. Circulation 114 (2006) 1388-1394
19. Miller F.P., Cox Jr. R.H., Snodgrass W.R., and Maickel R.P. Comparative effects of p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem. Pharmacol. 19 2 (1970) 435-442
20. Mulvany M.J. Vascular growth in hypertension. J. Cardiovasc. Pharmacol. 20 (1992) S7-S11
21. Murray B.M., and Paller M.S. Decreased pressor reactivity to angiotensin II in cirrhotic rats: evidence for a post-receptor defect in angiotensin action. Circ. Res. 57 (1985) 424-431
22. Navas-Acien A., Guallar E., Silbergeld E.K., and Rothenberg S.J. Lead exposure and cardiovascular disease-a systematic review. Environ. Health Perspect. 115 (2007) 472-482
23. Purdy R.E., Smith J.R., Ding Y., Oveisi F., Vaziri N.D., and Gonick H.C. Lead-induced hypertension is not associated with altered vascular reactivity in vitro. Am. J. Hypertens. 10 (1997) 997-1003
24. Roson M.I., Maquieira M.K., and de la Riva I.J. Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes. Clin. Exp. Hypertens. A12 (1990) 285-306
25. ω-l-arginine hypertensive rat. J. Pharmacol. Exp. Ther. 303 (2002) 179-187
26. Shelkovnikov S.A., and Gonick H.C. Influence of lead on rat thoracic aorta contraction and relaxation. Am. J. Hypertens. 14 (2001) 873-878
27. Skoczynska A., Wrobel J., and Andrzejak R. Lead-cadmium interaction effect on the responsiveness of rat mesenteric vessels to norepinephrine and angiotensin II. Toxicology 162 (2001) 157-170
28. Thompson L.P., and Webb R.C. Vascular responsiveness to serotonin metabolites in mineralocorticoid hypertension. Hypertension 9 (1987) 277-281
29. Ullmer C., Schmuck K., Kalkman H.O., and Lubbert H. Expression of serotonin receptor mRNAs in blood vessel. FEBS Lett. 370 (1995) 215-221
30. Vaziri N.D., Ding Y., and Ni Z. Nitric oxide synthase expression in the course of lead-induced hypertension. Hypertension 34 4 Pt 1 (1999) 558-562
31. Vaziri N.D., Ding Y., and Ni Z. Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension: reversal by a superoxide dismutase-mimetic drug. J. Pharmacol. Exp. Ther. 298 (2001) 679-685
32. Victery W. Evidence of effects on chronic lead exposure on blood pressure in experimental animals: an overview. Environ. Health Perspect. 78 (1988) 71-76
33. Watts S.W. The development of enhanced arterial serotonergic hyperresponsiveness in mineralocorticoid hypertension. J. Hypertens. 16 (1998) 811-822
34. Watts S.W., Baez M., and Webb R.C. The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertension. J. Pharmacol. Exp. Ther. 277 (1996) 1103-1113
35. 2B-receptor antagonist LY272015 is antihypertensive in DOCA-salt hypertensive rats. Am. J. Physiol. 276 (1999) H944-H952
36. Watts S.W., Gilbert L., and Webb R.C. 5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension 26 (1995) 1056-1059
37. Webb C.R., Winquist R.J., Victery W., and Vander A.J. In vivo and in vitro effects of lead on vascular reactivity in rats. Am. J. Physiol. 241 (1981) H211-H216
38. Zhang L.-F., Peng S.-Q., and Wang S. Influence of lead on the reactions of in vitro cultured rat aorta-increased responsiveness to 5-hydroxytryptamine. Toxicol. Lett. 159 (2005) 71-82
39. Zhang X.-M., Gu R.-J., Zhang Z.-X., Yin J.-G., and Chai J.-K. A rapid fluorophotometry for serum 5-hydroxytryptamine. Shanghai J. Med. Lab. Sci. 9 (1994) 21-22