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Volumn 276, Issue 3 45-3, 1999, Pages

5-HT(2B)-receptor antagonist LY-272015 is antihypertensive in DOCA- salt-hypertensive rats

Author keywords

5 hydroxytryptamine; Deoxycorticosterone acetate; Experimental hypertension; Serotonin receptors; Vasoconstriction

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; SEROTONIN ANTAGONIST; 1 (5 (2 THENYLOXY) 1H INDOL 3 YL)PROPAN 2 AMINE; 1-(5-(2-THENYLOXY)-1H-INDOL-3-YL)PROPAN-2-AMINE; ANTIHYPERTENSIVE AGENT; DEOXYCORTICOSTERONE; INDOLE DERIVATIVE; LY 272015; ORGANIC COMPOUND; SEROTONIN; SEROTONIN AGONIST; SODIUM CHLORIDE; THIOPHENE DERIVATIVE;

EID: 0033093789     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.3.h944     Document Type: Article
Times cited : (66)

References (38)
  • 3
    • 0028005526 scopus 로고
    • 2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat
    • 2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life Sci. 55: PL105-PL114, 1994.
    • (1994) Life Sci. , vol.55
    • Baez, M.1    Mercurio, L.2    Schenck, K.3    Cohen, M.L.4
  • 4
    • 0021079580 scopus 로고
    • Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade
    • Cohen, M. L., R. W. Fuller, and K. D. Kurz. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade. Hypertension 5: 676-681, 1983.
    • (1983) Hypertension , vol.5 , pp. 676-681
    • Cohen, M.L.1    Fuller, R.W.2    Kurz, K.D.3
  • 6
    • 0022510527 scopus 로고
    • Hypersensitivity of mesenteric veins to 5-hydroxytryptamine- and ketanserin-induced reduction of portal pressure in portal hypertensive rats
    • Cummings, S. A., R. J. Groszmann, and A. J. Kaumann. Hypersensitivity of mesenteric veins to 5-hydroxytryptamine- and ketanserin-induced reduction of portal pressure in portal hypertensive rats. Br. J. Pharmacol. 89: 501-513, 1986.
    • (1986) Br. J. Pharmacol. , vol.89 , pp. 501-513
    • Cummings, S.A.1    Groszmann, R.J.2    Kaumann, A.J.3
  • 7
    • 0023884457 scopus 로고
    • Central serotonergic alterations in deoxycorticosterone acetate/NaCl (DOCA/NaCl)-induced hypertension
    • Dawson, R., S. Nagamhama, and S. Oparil. Central serotonergic alterations in deoxycorticosterone acetate/NaCl (DOCA/NaCl)-induced hypertension. Neuropharmacology 27: 417-426, 1988.
    • (1988) Neuropharmacology , vol.27 , pp. 417-426
    • Dawson, R.1    Nagamhama, S.2    Oparil, S.3
  • 10
    • 0028985226 scopus 로고
    • Mediation by 5-hydroxytryptamine2B receptors of endothelium-dependent relaxation in rat jugular vein
    • Ellis, E. S., C. Byrne, O. E. Murphy, N. S. Tilford, and G. S. Baxter. Mediation by 5-hydroxytryptamine2B receptors of endothelium-dependent relaxation in rat jugular vein. Br. J. Pharmacol. 114: 400-404, 1995.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 400-404
    • Ellis, E.S.1    Byrne, C.2    Murphy, O.E.3    Tilford, N.S.4    Baxter, G.S.5
  • 12
    • 0029813756 scopus 로고    scopus 로고
    • Endothelial 5-HT receptors mediate relaxation of porcine pulmonary arteries in response to ergotamine and dihydroergotamine
    • Glusa, E., and A. Roos. Endothelial 5-HT receptors mediate relaxation of porcine pulmonary arteries in response to ergotamine and dihydroergotamine. Br. J. Pharmacol. 119: 330-334, 1996.
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 330-334
    • Glusa, E.1    Roos, A.2
  • 14
    • 0028885005 scopus 로고
    • Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs
    • Ito, A., K. Egashira, T. Kadokami, Y. Fukumoto, T. Takayanagi, R. Nakaike, T. Kuga, K. Sueishi, H. Shimokawa, and A. Takeshita. Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs. Circulation 92: 2636-2644, 1995.
    • (1995) Circulation , vol.92 , pp. 2636-2644
    • Ito, A.1    Egashira, K.2    Kadokami, T.3    Fukumoto, Y.4    Takayanagi, T.5    Nakaike, R.6    Kuga, T.7    Sueishi, K.8    Shimokawa, H.9    Takeshita, A.10
  • 15
    • 0021285418 scopus 로고
    • 3H-serotonin and endogenous content of serotonin in blood platelets in hypertensive patients
    • 3H-serotonin and endogenous content of serotonin in blood platelets in hypertensive patients. Hypertension 6: 568-573, 1984.
    • (1984) Hypertension , vol.6 , pp. 568-573
    • Kamal, L.1    Quan-Bui, K.H.L.2    Meyer, P.3
  • 16
    • 0023809046 scopus 로고
    • Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway
    • Kavanaugh, W. M., L. T. Williams, H. E. Ives, and S. R. Coughlin. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol. Endocrinol. 2: 599-605, 1988.
    • (1988) Mol. Endocrinol. , vol.2 , pp. 599-605
    • Kavanaugh, W.M.1    Williams, L.T.2    Ives, H.E.3    Coughlin, S.R.4
  • 19
    • 0028915622 scopus 로고
    • Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation
    • Loric, S., L. Maroteaux, O. Kellermann, and J. M. Launay. Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation. Mol. Pharmacol. 47: 458-466, 1995.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 458-466
    • Loric, S.1    Maroteaux, L.2    Kellermann, O.3    Launay, J.M.4
  • 20
    • 0029911551 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine receptor mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats
    • MacLean, M. R., G. Sweeney, M. Baird, K. M. McCulloch, M. Houslay, and I. Morecroft. 5-Hydroxytryptamine receptor mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol. 119: 917-930, 1996.
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 917-930
    • MacLean, M.R.1    Sweeney, G.2    Baird, M.3    McCulloch, K.M.4    Houslay, M.5    Morecroft, I.6
  • 21
    • 0027763163 scopus 로고
    • Amplifying interactions between spasmogens in vascular smooth muscle
    • MacLennan, S. J., M. L. Bolofo, and G. R. Martin. Amplifying interactions between spasmogens in vascular smooth muscle. Biochem. Soc. Trans. 21: 1145-1150, 1993.
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 1145-1150
    • MacLennan, S.J.1    Bolofo, M.L.2    Martin, G.R.3
  • 22
    • 0021711383 scopus 로고
    • Serotonin (5-HT) and its antagonists: Involvement in the cardiovascular system
    • Marwood, J. F., and G. S. Stokes. Serotonin (5-HT) and its antagonists: involvement in the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 11: 439-456, 1984.
    • (1984) Clin. Exp. Pharmacol. Physiol. , vol.11 , pp. 439-456
    • Marwood, J.F.1    Stokes, G.S.2
  • 23
    • 0014850574 scopus 로고
    • Vascular responses to 5-hydroxytryptamine in genetic and renal hypertensive rats
    • McGregor, D. D., and F. H. Smirk. Vascular responses to 5-hydroxytryptamine in genetic and renal hypertensive rats. Am. J. Physiol. 219: 687-690, 1970.
    • (1970) Am. J. Physiol. , vol.219 , pp. 687-690
    • McGregor, D.D.1    Smirk, F.H.2
  • 24
    • 0022376395 scopus 로고
    • Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle
    • Myers, J. H., T. E. Mecca, and R. C. Webb. Direct and sensitizing effects of serotonin agonists and antagonists on vascular smooth muscle. J. Cardiovasc. Pharmacol. 7: S44-S48, 1985.
    • (1985) J. Cardiovasc. Pharmacol. , vol.7
    • Myers, J.H.1    Mecca, T.E.2    Webb, R.C.3
  • 25
    • 0025232662 scopus 로고
    • Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes
    • Roson, M. I., M. K. Maquieira, and I. J. de la Riva. Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes. Clin. Exp. Hypertens. A12: 285-306, 1990.
    • (1990) Clin. Exp. Hypertens. , vol.A12 , pp. 285-306
    • Roson, M.I.1    Maquieira, M.K.2    De La Riva, I.J.3
  • 28
    • 0026082880 scopus 로고
    • An amplifying effect of exogenous and neuronally stored 5-hydroxytryptamine on the neurogenic contraction in rat tail artery
    • Szabo, C., J. E. Hardebo, and C. Owman. An amplifying effect of exogenous and neuronally stored 5-hydroxytryptamine on the neurogenic contraction in rat tail artery. Br. J. Pharmacol. 102: 401-407, 1991.
    • (1991) Br. J. Pharmacol. , vol.102 , pp. 401-407
    • Szabo, C.1    Hardebo, J.E.2    Owman, C.3
  • 29
    • 0023094145 scopus 로고
    • Vascular responsiveness to serotonin metabolites in mineralocorticoid hypertension
    • Thompson, L. P., and R. C. Webb. Vascular responsiveness to serotonin metabolites in mineralocorticoid hypertension. Hypertension 9: 277-281, 1987.
    • (1987) Hypertension , vol.9 , pp. 277-281
    • Thompson, L.P.1    Webb, R.C.2
  • 30
    • 25444474047 scopus 로고
    • A sensitive method for the assay of 5-hydroxytryptamine
    • Vane, J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br. J. Pharmacol. 12: 344-349, 1957.
    • (1957) Br. J. Pharmacol. , vol.12 , pp. 344-349
    • Vane, J.R.1
  • 31
    • 0026097787 scopus 로고
    • Serotonin, hypertension and vascular disease
    • Vanhoutte, P. M. Serotonin, hypertension and vascular disease. Neth. J. Med. 38: 35-42, 1991.
    • (1991) Neth. J. Med. , vol.38 , pp. 35-42
    • Vanhoutte, P.M.1
  • 35
    • 0031861805 scopus 로고    scopus 로고
    • The development of enhanced arterial serotonergic hyperresponsiveness in mineralocorticoid hypertension
    • Watts, S. W. The development of enhanced arterial serotonergic hyperresponsiveness in mineralocorticoid hypertension. J. Hypertens. 16: 811-822, 1998.
    • (1998) J. Hypertens. , vol.16 , pp. 811-822
    • Watts, S.W.1
  • 36
    • 33746834420 scopus 로고    scopus 로고
    • 2B receptor antagonist LY272015 inhibits 5-HT-induced contraction in the aorta of mineralocorticoid-salt hypertensive rats
    • In press
    • 2B receptor antagonist LY272015 inhibits 5-HT-induced contraction in the aorta of mineralocorticoid-salt hypertensive rats. J. Ser. Res. In press.
    • J. Ser. Res.
    • Watts, S.W.1
  • 37
    • 0030302110 scopus 로고    scopus 로고
    • The 5-hydroxytryptamineae receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertension
    • Watts, S. W., M. Baez, and R. C. Webb. The 5-hydroxytryptamineae receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertension. J. Pharmacol. Exp. Ther. 277: 1103-1113, 1996.
    • (1996) J. Pharmacol. Exp. Ther. , vol.277 , pp. 1103-1113
    • Watts, S.W.1    Baez, M.2    Webb, R.C.3
  • 38
    • 0028865535 scopus 로고
    • 2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats
    • 2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats. Hypertension 26: 1056-1059, 1995.
    • (1995) Hypertension , vol.26 , pp. 1056-1059
    • Watts, S.W.1    Gilbert, L.2    Webb, R.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.