Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum

Brain Research

Volumn 951, Issue 2, 2002, Pages 316-321

  Chung, Yoon Hee ^a   Shin, Chung Min ^a   Joo, Kyeung Min ^a   Kim, Myeung Ju ^a   Cha, Choong Ik ^a,b,c  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Korea National Institute of Health   (South Korea)

Author keywords

3 Nitrotyrosine; Aging; Cerebellum; Immunohistochemistry; Neuronal nitric oxide synthase; Oxidative damage; Rat

Indexed keywords

3 NITROTYROSINE; NITRIC OXIDE;

ADOLESCENT; AGE; AGED; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CONTROLLED STUDY; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT;

AGING; ANIMALS; CEREBELLAR CORTEX; CEREBELLUM; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; NEURONS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PURKINJE CELLS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE; UP-REGULATION;

EID: 0037019922     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03261-4     Document Type: Article

References (38)

1. Agarwal S., Sohal R.S. Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species. Exp. Gerontol. 31:1996;365-372.
2. Alexander T., Sortwell C.E., Sladek C.D., Roth R.H., Steece-Collier K. Comparison of neurotoxicity following repeated administration of L-dopa, D-dopa and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors. Cell Transplant. 6:1997;309-315.
3. Alper G., Girgin F.K., Özgönül M., Mentes G., Ersöz B. MAO inhibitors and oxidant stress in aging brain tissue. Eur. Neuropsychopharmacol. 9:1999;247-252.
4. Bickford P.C., Gould T., Breiderick L., Chadman K., Pollock A., Young D., Shukitt-Hale B., Joseph J. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 866:2000;211-217.
5. Browne S.E., Ferrante R.J., Beal M.F. Oxidative stress in Huntington's disease. Brain Pathol. 9:1999;147-163.
6. Butterfield D.A., Howard B.J., Yatin S., Allen K.L., Carney J.M. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. USA. 94:1997;674-678.
7. Butterfìeld D.A., Koppal T., Howard B., Subramaniam R., Hall N., Hensley K., Yatin S., Allen K., Aksenov M., Aksenova M., Carney J. Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E. Ann. N.Y. Acad. Sci. 854:1998;448-462.
8. Cakatay U., Telci A., Kayali R., Tekeli F., Akcay T., Sivas A. Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain. Exp. Gerontol. 36:2001;221-229.
9. Cha C.I., Kim J.M., Shin D.H., Kim Y.S., Kim J., Gurney M.E., Lee K.W. Reactive astrocytes express nitric oxide synthase in the spinal cord of transgenic mice expressing a human Cu/Zn SOD mutation. Neuroreport. 9:1998;1503-1506.
10. Cha C.I., Uhm M.R., Shin D.H., Chung Y.H., Baik S.H. Immunocytochemical study on the distribution of NOS-immunoreactive neurons in the cerebral cortex of aged rats. Neuroreport. 9:1998;2171-2174.
11. Cha C.I., Chung Y.H., Shin C.M., Shin D.H., Kim Y.S., Gurney M.E., Lee K.W. Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation. Brain Res. 853:2000;156-161.
12. Cha C.I., Sohn S.G., Chung Y.H., Shin C., Baik S.H. Region-specific changes of NOS-IR cells in the basal ganglia of the aged rat. Brain Res. 854:2000;239-244.
13. Chung Y.H., Shin C., Kim M.J., Lee B., Park K.H., Cha C.I. Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat. Brain Res. 885:2000;137-141.
14. Cini M., Moretti A. Studies on lipid peroxidation and protein oxidation in the aging brain. Neurobiol. Aging. 16:1995;53-57.
15. Crow J.P., Beckman J.S. The role of peroxynitrite in nitric oxide-mediated toxicity. Curr. Top. Microbiol. Immunol. 196:1995;57-73.
16. Doǧru-Abbaso lu S., Tamer-Toptani S., Uurnal B., Koçak-Toker N., Aykaç-Toker G., Uysal M. Lipid peroxidation and antioxidant enzymes in livers and brains of aged rats. Mech. Ageing Dev. 98:1997;177-180.
17. Driver A.S., Kodavanti P.R., Mundy W.R. Age-related changes in reactive oxygen species production in rat brain homogenates. Neurotoxicol. Teratol. 22:2000;175-181.
18. Dubey A., Forster M.J., Lal H., Sohal R.S. Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch. Biochem. Biophys. 333:1996;189-197.
19. Evans P., Lyras L., Halliwell B. Measurement of protein carbonyls in human brain tissue. Methods Enzymol. 300:1999;145-156.
20. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature. 408:2000;239-247.
21. Forster M.J., Dubey A., Dawson K.M., Stutts W.A., Lal H., Sohal R.S. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc. Natl. Acad. Sci. USA. 93:1996;4765-4769.
22. Good P.F., Werner P., Hsu A., Olanow C.W., Perl D.P. Evidence of neuronal oxidative damage in Alzheimer's disease. Am. J. Pathol. 149:1996;21-28.
23. Johnson T.M., Yu Z.X., Ferrans V.J., Lowenstein R.A., Finkel T. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA. 93:1996;11848-11852.
24. Kawai M., Matsuura S., Asanuma M., Ogawa N. Manda, a fermented natural food, suppresses lipid peroxidation in the senescent rat brain. Neurochem. Res. 23:1998;455-461.
25. Le Bourg E. Oxidative stress, aging and longevity in Drosophila melanogaster. FEBS Lett. 498:2001;183-186.
26. Leutner S., Eckert A., Muller W.E. ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J. Neural Transm. 108:2001;955-967.
27. Martinez M., Hernandez A.I., Martinez N., Ferrandiz M.L. Age-related increase in oxidized proteins in mouse synaptic mitochondria. Brain Res. 731:1996;246-248.
28. Masoro E.J. Caloric restriction and aging: an update. Exp. Gerontol. 35:2000;299-305.
29. Merrill J.E., Murphy S.P. Regulation of gene expression in the nervous system by reactive oxygen and nitrogen species. Metab. Brain Dis. 12:1997;97-112.
30. O'Donnell E., Lynch M.A. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol. Aging. 19:1998;461-467.
31. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., Vogelstein B. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
32. Sahoo A., Chainy G.B. Alterations in the activities of cerebral antioxidant enzymes of rat are related to aging. Int. J. Dev. Neurosci. 15:1997;939-948.
33. Shin C.M., Chung Y.H., Kim M.J., Lee E.Y., Kim E.G., Cha C.I. Age-related changes in the distribution of nitrotyrosine in the cerebral cortex and hippocampus of rats. Brain Res. 931:2002;194-199.
34. Stadtman E.R. Protein oxidation and aging. Science. 257:1992;1220-1224.
35. Su J.H., Deng G., Cotman C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 774:1997;193-199.
36. Teunissen C.E., Markerink-van Ittersum M., de Bruijn C., Steinbusch H.W., de Vente J. Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures. Brain Res. 931:2002;5-20.
37. Tian L., Cai Q., Wei H. Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic. Biol. Med. 24:1998;1477-1484.
38. Yu W., Juang S., Lee J., Liu T., Cheng J. Decrease of neuronal nitric oxide synthase in the cerebellum of aged rats. Neurosci. Lett. 291:2000;37-40.