Asymmetric dieckmann condensation via memory of chirality: synthesis of the key intermediate for as-3201, an aldose reductase inhibitor

Heterocycles

Volumn 76, Issue 2, 2008, Pages 1593-1606

  Watanabe, Toshihide ^a   Kawabata, Takeo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Amino Acid; Axially Chiral Enolate; Diabetes; Dynamic Chirality

Indexed keywords

EID: 61349145077     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-08-S(N)126     Document Type: Article

References (15)

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15. The yield and ee of the Dieckmann condensation of 2 in various solvents are as follows: toluene; 12% yield, 61% ee: ether; 22% yield, 75% ee: diisopropyl ether; 18% yield, 72% ee: cyclopropyl methyl ether; 17% yield, 67% ee: tert-butyl methyl ether; 24% yield, 78% ee.