Studies on self-aggregation of anthracycline drugs by restrained molecular dynamics approach using nuclear magnetic resonance spectroscopy supported by absorption, fluorescence, diffusion ordered spectroscopy and mass spectrometry

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1437-1451

  Agrawal, Prashansa ^a   Barthwal, Sudhir Kumar ^a   Barthwal, Ritu ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

2D nuclear Overhauser enhancement spectroscopy; 4 Epiadriamycin, adriamycin and daunomycin; Cardiotoxicity; Diffusion ordered spectroscopy; Electron spray ionization mass spectrometry; Restrained molecular dynamics

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; DAUNORUBICIN; DIMER; DOXORUBICIN; EPIRUBICIN;

ABSORPTION SPECTROSCOPY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARDIOTOXICITY; CHROMATOPHORE; COMPLEX FORMATION; DIFFUSION ORDERED SPECTROSCOPY; DNA BINDING; DRUG DNA BINDING; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ABSORPTION; ANTHRACYCLINES; ANTINEOPLASTIC AGENTS; DIFFUSION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 61349131998     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.037     Document Type: Article

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