The Use of Flat Panel Volumetric Computed Tomography (fpVCT) in Osteoporosis Research

Academic Radiology

Volumn 16, Issue 4, 2009, Pages 394-400

  Sehmisch, Stephan ^a   Dullin, Christian ^a   Zaroban, Artur ^a   Tezval, Mohammad ^a   Rack, Thomas ^a   Schmelz, Ullrich ^a   Seidlova Wuttke, Dana ^a   Dunkelberg, Hartmut ^a   Wuttke, Wolfgang ^a   Marten, Katharina ^a   Stuermer, Klaus Michael ^a   Stuermer, Ewa Klara ^a  

^a Medical Institute of General Hygiene and Environmental Health   (Germany)

Author keywords

biomechanical test; bone microstructure; fpVCT; osteoporosis

Indexed keywords

ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE STRUCTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; LUMBAR VERTEBRA; MEDICAL RESEARCH; NONHUMAN; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; TRABECULAR BONE; VITAMIN SUPPLEMENTATION; VOLUMETRY;

ABSORPTIOMETRY, PHOTON; ANIMALS; BONE DENSITY; BONE DISEASES, METABOLIC; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; X-RAY INTENSIFYING SCREENS;

EID: 61349115654     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2008.09.017     Document Type: Article

References (29)

1. Flohr T., Stierstorfer K., Bruder H., et al. New technical developments in multislice CT-part 1: approaching isotropic resolution with sub-millimeter 16-slice scanning. Rofo 174 (2002) 839-845
2. Völk M., Hamer O.W., Feuerbach S., et al. Dose reduction in skeletal and chest radiography using a large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide: technical background, basic image quality parameters, and review of the literature. Eur Radiol 14 (2004) 827-834
3. Groh B.A., Siewerdsen J.H., Drake D.G., et al. A performance comparison of flat-panel imager-based MV and kV cone-beam CT. Med Phys 29 (2002) 967-975
4. Ludwig K., Henschel A., Bernhardt T.M., et al. Performance of a flat-panel detector in the detection of artificial erosive changes: comparison with conventional screen-film and storage-phosphor radiography. Eur Radiol 13 (2003) 1316-1323
5. Nikolaou K., Flohr T., Stierstorfer K., et al. Flat panel computed tomography of human ex vivo heart and bone specimens: initial experience. Eur Radiol 15 (2005) 329-333
6. Siris E., Adachi J.D., Lu Y., et al. Effects of raloxifene on fracture severity in postmenopausal women with osteoporosis: results from the MORE study. Osteoporos Int 13 (2002) 907-913
7. Lindsay R., Gallagher J.C., Kleerekoper M., et al. Bone response to treatment with lower doses of conjugated estrogens with and without medroxyprogesterone acetate in early postmenopausal women. Osteoporos Int 16 (2005) 372-379
8. Genant H.K., Delmas P.D., Chen P., et al. Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 18 (2007) 69-76
9. Erlandsson M.C., Jonsson C.A., Lindberg M.K., et al. Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. J Endocrinol 175 (2002) 319-327
10. Rossouw J.E., Anderson G.L., Prentice R.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
11. Stürmer E.K., Seidlová-Wuttke D., Sehmisch S., et al. Standardized bending and breaking test for the normal and osteoporotic metaphyseal tibias of the rat: effect of estradiol, testosterone, and raloxifene. J Bone Miner Res 21 (2006) 89-96
12. Stürmer K.M., and Schmit-Neuerburg K.P. Quantitative determination of the effect of induced alternating currents on the integration of autologous spongiosa transplants. Unfallchirurgie 11 (1985) 168-173
13. Bitterling H., Vogel T., Dobler T., et al. Role of osteoporosis in trauma diagnostics. Rofo 177 (2005) 1663-1669
14. Guglielmi G., and Lang T.F. Quantitative computed tomography. Semin Musculoskelet Radiol 6 (2002) 219-227
15. Prevrhal S., and Genant H.K. Quantitative computer tomography. Radiologe 39 (1999) 194-202
16. Raisz L.G. Clinical practice. Screening for osteoporosis. N Engl J Med 353 (2005) 164-171
17. Engelke K., Karolczak M., Lutz A., et al. Micro-CT. Technology and application for assessing bone structure. Radiologe 39 (1999) 203-212
18. Felsenberg D., and Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther 27 (2005) 1-11
19. Martin-Badosa E., Amblard D., Nuzzo S., et al. Excised bone structures in mice: imaging at three-dimensional synchrotron radiation micro CT. Radiology 229 (2003) 921-928
20. Obert M., Ahlemeyer B., Baumgart-Vogt E., et al. Flat-panel computed tomography: a new method for visualizing fine bone detail in living mice. J Comput Assist Tomogr 29 (2005) 560-565
21. Kuiper J.W., van Kuijk C., Grashuis J.L., et al. Accuracy and the influence of marrow fat on quantitative CT and dual-energy x-ray absorptiometry measurements of the femoral neck in vitro. Osteoporosis Int 6 (1996) 25-30
22. Glüer C.C., and Genant H.K. Impact of marrow fat in accuracy of quantitative CT. J Comput Assist Tomogr 13 (1989) 1023-1035
23. Gupta R., Bartling S.H., Basu S.K., et al. Experimental flat-panel high-spatial-resolution volume CT of the temporal bone. AJNR Am J Neuroradiol 25 (2004) 1417-1424
24. Taschereau R., Chow P.L., and Chatziioannou A.F. Monte Carlo simulations of dose from microCT imaging procedures in a realistic mouse phantom. Med Phys 33 (2006) 216-224
25. Missbach-Guentner J., Dullin C., Zientkowska M., et al. Flat-panel detector-based volume computed tomography: a novel 3D imaging technique to monitor osteolytic bone lesions in a mouse tumor metastasis model. Neoplasia 9 (2007) 755-765
26. Missbach-Guentner J., Dullin C., Kimmina S., et al. Morphological changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography. Neoplasia 10 (2008) 663-673
27. Greschus S., Kiessling F., Lichy M.P., et al. Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging. Neoplasia 7 (2005) 730-740
28. Kiessling F., Greschus S., Lichy M.P., et al. Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med 10 (2005) 1133-1138
29. Reichardt B., Sarwar A., Bartling S.H., et al. Musculoskeletal applications of flat-panel volume CT. Skeletal Radiol 37 (2008) 1069-1076