Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, Part 1

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1710-1717

  Herold, Franciszek ^a   Chodkowski, Andrzej ^a   Izbicki, Łukasz ^a   Król, Marek ^a   Kleps, Jerzy ^a   Turło, Jadwiga ^a   Nowak, Gabriel ^b,c   Stachowicz, Katarzyna ^b   Dybała, Małgorzata ^c   Siwek, Agata ^c  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

5 HT1A 5 HT T dual activity; Antidepressants; Depression; Pyrido 1,2 c pyrimidines

Indexed keywords

2 [4 [4 (1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL] 4 4 TOLYLPYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 2 [4 [4 (1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL] 4 PHENYLPYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE; 2 [4 [4 (1H INDOLE 3 YL)PIPERIDIN 1 YL]BUTYL] 4 (4 METHOXYPHENYL)PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 2 [4 [4 (5 METHOXY 1H INDOL 3 YL)PIPERIDIN 1 YL] BUTYL] 4 4 TOLYLPYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 2 [4 [4 (5 METHOXY 1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL] 4 (4 METHOXYPHENYL)PYRIDO[1,2C]PYRIMIDINE 1,3 DIONE; 2 [4 [4 (5 METHOXY 1H INDOLE 3 YL)PIPERIDIN 1 YL]BUTYL] 4 PHENYLPYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 FLUOROPHENYL) 2 [4 [4 (1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL]PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (2 FLUOROPHENYL) 2 [4 [4 (5 METHOXY 1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL]PYRIDOL[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 CHLOROPHENYL) 2 [4 [4 (1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL]PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 CHLOROPHENYL) 2 [4 [4 (5 METHOXY 1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL]PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 FLUOROPHENYL) 2 [4 [4 (1H INDOL 3YL)PIPERIDIN 1 YL]BUTYL]PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; 4 (4 FLUOROPHENYL) 2 [4 [4 (5 METHOXY 1H INDOL 3 YL)PIPERIDIN 1 YL]BUTYL]PYRIDO[1,2 C]PYRIMIDINE 1,3 DIONE; AUTORECEPTOR; POSTSYNAPTIC RECEPTOR; PYRIMIDINE DERIVATIVE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; BRAIN MEMBRANE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; HYPOTHERMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BODY TEMPERATURE; DRUG DESIGN; HYPOTHERMIA; IMMOBILIZATION; LIGANDS; MALE; MICE; PIPERAZINES; PYRIDINES; PYRIMIDINES; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SWIMMING;

EID: 61349107179     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.021     Document Type: Article

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