MicroRNAs in the ontogeny of leukemias and lymphomas

Leukemia and Lymphoma

Volumn 50, Issue 2, 2009, Pages 160-170

  Fabbri, Muller ^a   Croce, Carlo ^a   Calin, George ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Hematopoiesis; Leukemia; Lymphoma; MicroRNA; Ontogeny

Indexed keywords

MICRORNA; MIR 17 92; MIR 181A; MIR 223; MYC PROTEIN; NUCLEIC ACID; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADAPTIVE IMMUNITY; B LYMPHOCYTE ACTIVATION; BURKITT LYMPHOMA; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TARGETING; HODGKIN DISEASE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LEUKEMIA; LYMPHOCYTE DIFFERENTIATION; LYMPHOMA; MEGAKARYOCYTE; MYELOID LEUKEMIA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ADAPTATION, BIOLOGICAL; ANIMALS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LEUKEMIA; LYMPHOMA; MICRORNAS;

EID: 61349103883     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190802535114     Document Type: Review

References (99)

1. Ambros, V. and Lee, R. C. (2004) Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. Methods Mol Biol, 265, pp. 131-158.
2. Bartel, D. P. (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, pp. 281-297.
3. He, L. and Hannon, G. J. (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet, 5, pp. 522-531.
4. Plasterk, R. H. (2006) Micro RNAs in animal development. Cell, 124, pp. 877-881.
5. Pasquinelli, A. E., Hunter, S. and Bracht, J. (2005) MicroRNAs: A developing story. Curr Opin Genet Dev, 15, pp. 200-205.
6. Carleton, M., Cleary, M. A. and Linsley, P. S. (2007) MicroRNAs and cell cycle regulation. Cell Cycle, 6, pp. 2127-2132.
7. Lee, Y., Kim, M., Han, J., Yeom, K. H., Lee, S. Baek, S. H. et al. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J, 23, pp. 4051-4060.
8. Cai, X., Hagedorn, C. H. and Cullen, B. R. (2004) Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA, 10, pp. 1957-1966.
9. Liu, C. G., Calin, G. A., Meloon, B., Gamliel, N., Sevignani, C. Ferracin, M. et al. (2004) An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA, 101, pp. 9740-9744.
10. Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J. Peck, D. et al. (2005) MicroRNA expression profiles classify human cancers. Nature, 435, pp. 834-838.
11. Schmittgen, T. D., Jiang, J., Liu, Q. and Yang, L. (2004) A high-throughput method to monitor the expression of microRNA precursor. Nucleic Acids Res, 32, pp. 43-53.
12. Raymond, C. K., Roberts, B. S., Garrett-Engele, P., Lim, L. P. and Johnson, J. M. (2005) Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA, 11, pp. 1737-1744.
13. Cummins, J. M., He, Y., Leary, R. J., Pagliarini, R., Diaz Jr, L. A. Sjoblom, T. et al. (2006) The colorectal microRNAome. Proc Natl Acad Sci USA, 103, pp. 3687-3692.
14. Nelson, P. T., Baldwin, D. A., Scearce, L. M., Oberholtzer, J. C., Tobias, J. W. and Mourelatos, Z. (2004) Microarray-based, high-throughput gene expression profiling of microRNAs. Nat Methods, 1, pp. 155-161.
15. Medina, P. P. and Slack, F. J. (2008) MicroRNAs and cancer: An overview. Cell Cycle, 7, pp. 2485-2492.
16. Garzon, R. and Croce, C. M. (2008) MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol, 15, pp. 352-358.
17. Croce, C. M. and Calin, G. A. (2005) MiRNAs, cancer, and stem cell division. Cell, 122, pp. 6-7.
18. Greaves, M. F. (1986) Differentiation-linked leukemogenesis in lymphocytes. Science, 234, pp. 697-704.
19. Georgantas III, R. W., Hildreth, R., Morisot, S., Alder, J., Liu, C. G. Heimfeld, S. et al. (2007) CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control. Proc Natl Acad Sci USA, 104, pp. 2750-2755.
20. Chen, C. Z., Li, L., Lodish, H. F. and Bartel, D. P. (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science, 303, pp. 83-86.
21. Neilson, J. R., Zheng, G. X., Burge, C. B. and Sharp, P. A. (2007) Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev, 21, pp. 578-589.
22. Nakayama, T., Kasprowicz, D. J., Yamashita, M., Schubert, L. A., Gillard, G. Kimura, M. et al. (2002) The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol, 168, pp. 87-94.
23. Zhou, B., Wang, S., Mayr, C., Bartel, D. P. and Lodish, H. F. (2007) MiR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci USA, 104, pp. 7080-7085.
24. Monticelli, S., Ansel, K. M., Xiao, C., Socci, N. D., Krichevsky, A. M. Thai, T. H. et al. (2005) MicroRNA profiling of the murine hematopoietic system. Genome Biol, 6, p. R71.
25. Xiao, C., Calado, D. P., Galler, G., Thai, T. H., Patterson, H. C. Wang, J. et al. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell, 131, pp. 146-159.
26. Koralov, S. B., Muljo, S. A., Galler, G. R., Krek, A., Chakraborty, T. Kanellopoulou, C. et al. (2008) Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell, 132, pp. 860-874.
27. Ventura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A. Erkeland, S. J. et al. (2008) Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell, 132, pp. 875-886.
28. Tam, W. (2001) Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene, 274, pp. 157-167.
29. Taganov, K. D., Boldin, M. P., Chang, K. J. and Baltimore, D. (2006) NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA, 103, pp. 12481-12486.
30. Vigorito, E., Perks, K. L., Abreu-Goodger, C., Bunting, S., Xiang, Z. Kohlhaas, S. et al. (2007) MicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity, 27, pp. 847-859.
31. Thai, T. H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C. Xue, Y. et al. (2007) Regulation of the germinal center response by microRNA-155. Science, 316, pp. 604-608.
32. Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P. Soond, D. R. et al. (2007) Requirement of bic/microRNA-155 for normal immune function. Science, 316, pp. 608-611.
33. Xiao, C., Srinivasan, L., Calado, D. P., Patterson, H. C., Zhang, B. Wang, J. et al. (2008) Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol, 9, pp. 405-414.
34. Li, Q. J., Chau, J., Ebert, P. J., Sylvester, G., Min, H. Liu, G. et al. (2007) MiR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell, 129, pp. 147-161.
35. Mendell, J. T. (2008) MiRiad roles for the miR-17-92 cluster in development and disease. Cell, 133, pp. 217-222.
36. Mi, S., Lu, J., Sun, M., Li, Z., Zhang, H. Neilly, M. B. et al. (2007) MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA, 104, pp. 19971-19976.
37. Bullrich, F., Fujii, H., Calin, G., Mabuchi, H., Negrini, M. Pekarsky, Y. et al. (2001) Characterization of the 13q14 tumor suppressor locus in CLL: Identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res, 61, pp. 6640-6648.
38. Burlinger, L., Dohner, K., Bair, E., Frohling, S., Schlenk, R. F. Tibshirani, R. et al. (2004) Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med, 350, pp. 1605-1616.
39. Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S. Noch, E. et al. (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 99, pp. 15524-15529.
40. Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M. Shimizu, M. et al. (2005) MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA, 102, pp. 13944-13949.
41. Kitada, S., Andersen, J., Akar, S., Zapata, J. M., Takayama, S. Krajewski, S. et al. (1998) Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses. Blood, 91, pp. 3379-3389.
42. Adachi, M., Tefferi, A., Greipp, P. R., Kipps, T. J. and Tsujimoto, Y. (1990) Preferential linkage of BCL-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia. J Exp Med, 171, pp. 559-564.
43. Calin, G. A., Ferracin, M., Cimmino, A., Di Leva, G, Shimizu, M. Wojcik, S. E. et al. (2005) A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med, 353, pp. 1793-1801.
44. Scaglione, B. J., Salerno, E., Balan, M., Coffman, F., Landgraf, P. Abbasi, F. et al. (2007) Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand black mouse model. Br J Haematol, 139, pp. 645-657.
45. Raveche, E. S., Salerno, E., Scaglione, B. J., Manohar, V., Abbasi, F. Lin, Y. C. et al. (2007) Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood, 109, pp. 5079-5086.
46. Calin, G. A., Cimmino, A., Fabbri, M., Ferracin, M., Wojcik, S. E. Shimizu, M. et al. (2008) MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA, 105, pp. 5166-5171.
47. Fabbri, M., Ivan, M., Cimmino, A., Negrini, M. and Calin, G. A. (2007) Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther, 7, pp. 1009-1019.
48. Pekarsky, Y., Santanam, U., Cimmino, A., Palamarchuk, A., Efanov, A. Maximov, V. et al. (2006) TCL1 expression in CLL is regulated by miR-29 and miR-181. Cancer Res, 66, pp. 11590-11593.
49. Chan, T. O., Rittenhouse, S. E. and Tsichlis, P. N. (1999) AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem, 68, pp. 965-1014.
50. Yan, X. J., Albesiano, E., Zanesi, N., Yancopoulos, S., Sawyer, A. Romano, E. et al. (2006) B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 103, pp. 11713-11718.
51. Herling, M., Patel, K. A., Khalili, J., Schlette, E., Kobayashi, R. Medeiros, L. J. et al. (2006) TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia, 20, pp. 280-285.
52. Marton, S., Garcia, M. R., Robello, C., Persson, H., Trajtenberg, F. Pritsch, O. et al. (2008) Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia, 22, pp. 330-338.
53. Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z. Gomez, M. F. et al. (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA, 102, pp. 3627-3632.
54. Tam, W., Hughes, S. H., Hayward, W. S. and Besmer, P. (2002) Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis. J Virol, 76, pp. 4275-4286.
55. Metzler, M., Wilda, M., Busch, K., Viehmann, S. and Borkhardt, A. (2004) High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer, 39, pp. 167-169.
56. Kluiver, J., Haralambieva, E., de Jong, D., Blokzijl, T., Jacobs, S. Kroesen, B. J. et al. (2006) Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma. Genes Chromosomes Cancer, 45, pp. 147-153.
57. Kluiver, J., van den Berg, A, de Jong, D., Blokzijl, T., Harms, G. Bouwman, E. et al. (2007) Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. Oncogene, 26, pp. 3769-3776.
58. Costinean, S., Zanesi, N., Pekarsky, Y., Tili, E., Volinia, S. Heerema, N. et al. (2006) Pre-B cell proliferation and lymphoblastic leukemia/ high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA, 103, pp. 7024-7029.
59. Lawrie, C. H., Soneji, S., Marafioti, T., Cooper, C. D., Palazzo, S. Paterson, J. C. et al. (2007) Microrna expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Int J Cancer, 121, pp. 1156-1161.
60. Roehle, A., Hoefig, K. P., Repsilber, D., Thorns, C., Ziepert, M. Wesche, K. O. et al. (2008) MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. Br J Haematol, 142, pp. 732-744.
61. Rosenwald, A., Wright, G., Leroy, K., Yu, X., Gaulard, P. Gascoyne, R. D. et al. (2003) Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med, 198, pp. 851-862.
62. Rai, D., Karanti, S., Jung, I., Dahia, P. L. and Aguiar, R. C. (2008) Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma. Cancer Genet Cytogenet, 181, pp. 8-15.
63. He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D. Goodson, S. et al. (2005) A microRNA polycistron as a potential human oncogene. Nature, 435, pp. 828-833.
64. Ota, A., Tagawa, H., Karnan, S., Tsuzuki, S., Karpas, A. Kira, S. et al. (2004) Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res, 64, pp. 3087-3095.
65. O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V. and Mendell, J. T. (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature, 435, pp. 839-843.
66. Leone, G., DeGregori, J., Sears, R., Jakoi, L. and Nevins, J. R. (1997) Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature, 387, pp. 422-426.
67. Landais, S., Landry, S., Legault, P. and Rassart, E. (2007) Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res, 67, pp. 5699-5707.
68. Akao, Y., Nakagawa, Y., Kitade, Y., Kinoshita, T. and Naoe, T. (2007) Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci, 98, pp. 1914-1920.
69. Nishimoto, S. and Nishida, E. (2006) MAPK signalling: ERK5 versus ERK1/ 2. EMBO Rep, 7, pp. 782-786.
70. Akao, Y., Nakagawa, Y. and Naoe, T. (2007) MicroRNA-143 and -145 in colon cancer. DNA Cell Biol, 26, pp. 311-320.
71. Navarro, A., Gaya, A., Martinez, A., Urbano-Ispizua, A., Pons, A. Balague, O. et al. (2008) MicroRNA expression profiling in classical Hodgkin lymphoma. Blood, 111, pp. 2825-2832.
72. Nie, K., Gomez, M., Landgraf, P., Garcia, J. F., Liu, Y. Tan, L. H. et al. (2008) MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/ Reed-Sternberg cells: A potential pathogenetic lesion in Hodgkin lymphomas. Am J Pathol, 173, pp. 242-252.
73. Pasqualucci, L., Compagno, M., Houldsworth, J., Monti, S., Grunn, A. Nandula, S. V. et al. (2006) Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med, 203, pp. 311-317.
74. Kluiver, J., Poppema, S., de Jong, D., Blokzijl, T., Harms, G. Jacobs, S. et al. (2005) BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol, 207, pp. 243-249.
75. Kuppers, R. (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer, 5, pp. 251-262.
76. Volinia, S., Calin, G. A., Liu, C. G., Ambs, S., Cimmino, A. Petrocca, F. et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA, 103, pp. 2257-2261.
77. Garzon, R., Pichiorri, F., Palumbo, T., Visentini, M., Aqeilan, R. Cimmino, A. et al. (2007) MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene, 26, pp. 4148-4157.
78. Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M. L. Nervi, C. et al. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell, 123, pp. 819-831.
79. Johnnidis, J. B., Harris, M. H., Wheeler, R. T., Stehling-Sun, S., Lam, M. H. Kirak, O. et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature, 451, pp. 1125-1129.
80. Fukao, T., Fukuda, Y., Kiga, K., Sharif, J., Hino, K. Enomoto, Y. et al. (2007) An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell, 129, pp. 617-631.
81. Fontana, L., Pelosi, E., Greco, P., Racanicchi, S., Testa, U. Liuzzi, F. et al. (2007) MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol, 9, pp. 775-787.
82. Garzon, R., Pichiorri, F., Palumbo, T., Iuliano, R., Cimmino, A. Aqeilan, R. et al. (2006) MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci USA, 103, pp. 5078-5083.
83. Labbaye, C., Spinello, I., Quaranta, M. T., Pelosi, E., Pasquini, L. Petrucci, E. et al. (2008) A three-step pathway comprising PLZF/miR-146a/ CXCR4 controls megakaryopoiesis. Nat Cell Biol, 10, pp. 788-801.
84. Pang, L., Weiss, M. J. and Poncz, M. (2005) Megakaryocyte biology and related disorders. J Clin Invest, 115, pp. 3332-3338.
85. Felli, N., Fontana, L., Pelosi, E., Botta, R., Bonci, D. Facchiano, F. et al. (2005) MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA, 102, pp. 18081-18086.
86. Bruchova, H., Yoon, D., Agarwal, A. M., Mendell, J. and Prchal, J. T. (2007) Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol, 35, pp. 1657-1667.
87. O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., Boldin, M. P., Taganov, K. D. Nicoll, J. et al. (2008) Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med, 205, pp. 585-594.
88. Dore, L. C., Amigo, J. D., Dos Santos, C O, Zhang, Z., Gai, X. Tobias, J. W. et al. (2008) A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci USA, 105, pp. 3333-3338.
89. O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G. and Baltimore, D. (2007) MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA, 104, pp. 1604-1609.
90. Tili, E., Michaille, J. J., Cimino, A., Costinean, S., Dumitru, C. D. Adair, B. et al. (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-{α} stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol, 179, pp. 5082-5089.
91. Perry, M. M., Moschos, S. A., Williams, A. E., Shepherd, N. J., Larner-Svensson, H. M. and Lindsay, M. A. (2008) Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells. J Immunol, 180, pp. 5689-5698.
92. Garzon, R., Volinia, S., Liu, C. G., Fernandez-Cymering, C., Palumbo, T. Pichiorri, F. et al. (2008) MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood, 111, pp. 3183-3189.
93. Garzon, R., Garofalo, M., Martelli, M. P., Briesewitz, R., Wang, L. Fernandez-Cymering, C. et al. (2008) Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA, 105, pp. 3945-3950.
94. Burnett, A. K. (2002) Current controversies: Which patients with acute myeloid leukaemia should receive a bone marrow transplantation? - An adult treater's view. Br J Haematol, 118, pp. 357-364.
95. Marcucci, G., Radmacher, M. D., Maharry, K., Mrozek, K., Ruppert, A. S. Paschka, P. et al. (2008) MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med, 358, pp. 1919-1928.
96. Fazi, F., Racanicchi, S., Zardo, G., Starnes, L. M., Mancini, M. Travaglini, L. et al. (2007) Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell, 12, pp. 457-466.
97. Venturini, L., Battmer, K., Castoldi, M., Schultheis, B., Hochhaus, A. Muckenthaler, M. U. et al. (2007) Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells. Blood, 109, pp. 4399-4405.
98. Bueno, M. J., Perez de Castro, I, Gomez de Cedron, M, Santos, J., Calin, G. A. Cigudosa, J. C. et al. (2008) Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 13, pp. 496-506.
99. Zanette, D. L., Rivadavia, F., Molfetta, G. A., Barbuzano, F. G., Proto-Siqueira, R. Silva Jr, W. A. et al. (2007) miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res, 40, pp. 1435-1440.