Effective suppression of replication of porcine reproductive and respiratory syndrome virus by adenovirus-mediated small interfering RNAs targeting ORF1b, 5 and 7 genes

Journal of Virological Methods

Volumn 157, Issue 1, 2009, Pages 40-46

  Li, Guangming ^a   Jiang, Ping ^a   Li, Yufeng ^a   Wang, Xianwei ^a   Huang, Juan ^a   Du, Yijun ^a   Zeshan, Basit ^a  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

Author keywords

Adenovirus; PRRSV; RNAi; shRNA

Indexed keywords

PROTEIN ORF 1B; PROTEIN ORF 5; PROTEIN ORF 7; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTERIVIRUS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; MONKEY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS GENOME; VIRUS LOAD; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; CELL LINE; CELLS, CULTURED; MACROPHAGES, ALVEOLAR; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RNA, SMALL INTERFERING; SWINE; VIRAL PROTEINS;

ADENOVIRIDAE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 60849130685     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jviromet.2008.12.001     Document Type: Article

References (37)

1. Andersson M.G., Haasnoot P.C., Xu N., Berenjian S., Berkhout B., and Akusjarvi G. Suppression of RNA interference by adenovirus virus-associated RNA. J. Virol. 79 (2005) 9556-9565
2. Chen W., Liu M., Jiao Y., Yan W., Wei X., Chen J., Fei L., Liu Y., Zuo X., Yang F., Lu Y., and Zheng Z. Adenovirus-mediated RNA interference against foot-and-mouth disease virus infection both in vitro and in vivo. J. Virol. 80 (2006) 3559-3566
3. Chen M., Payne W.S., Hunt H., Zhang H., Holmen S.L., and Dodgson J.B. Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference. Virology 377 (2008) 265-272
4. Christopher-Hennings J., Nelson E.A., Hines R.J., Nelson J.K., Swenson S.L., Zimmerman J.J., Chase C.L., Yaeger M.J., and Benfield D.A. Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars. J. Vet. Diagn. Invest. 7 (1995) 456-464
5. Dea S., Gagnon C.A., Mardassi H., Pirzadeh B., and Rogan D. Current knowledge on the structural proteins of porcine reproductive and respiratory syndrome (PRRS) virus: comparison of the North American and European isolates. Arch. Virol. 145 (2000) 659-688
6. Delputte P.L., Meerts P., Costers S., and Nauwynck H.J. Effect of virus-specific antibodies on attachment, internalization and infection of porcine reproductive and respiratory syndrome virus in primary macrophages. Vet. Immunol. Immunopathol. 102 (2004) 179-188
7. den Boon J.A., Faaberg K.S., Meulenberg J.J., Wassenaar A.L., Plagemann P.G., Gorbalenya A.E., and Snijder E.J. Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases. J. Virol. 69 (1995) 4500-4505
8. Feng Z., Jiang P., Wang X., Li Y., and Jiang W. Adenovirus-mediated shRNA interference against porcine circovirus type 2 replication both in vitro and in vivo. Antiviral. Res. 77 (2008) 186-194
9. Galiana-Arnoux D., Dostert C., Schneemann A., Hoffmann J.A., and Imler J.L. Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila. Nat. Immunol. 7 (2006) 590-597
10. Grebennikova T.V., Clouser D.F., Vorwald A.C., Musienko M.I., Mengeling W.L., Lager K.M., Wesley R.D., Biketov S.F., Zaberezhny A.D., Aliper T.I., and Nepoklonov E.A. Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain. Virology 321 (2004) 383-390
11. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2509-2514
12. He Y.X., Hua R.H., Zhou Y.J., An T.Q., Qiu H.J., Wang Y.F., and Tong G.Z. Selection and inhibitory effect analysis of siRNAs specific to ORF2-4 of porcine reproductive and respiratory syndrome virus. Sheng Wu Gong Cheng Xue Bao 23 (2007) 794-800
13. He Y.X., Hua R.H., Zhou Y.J., Qiu H.J., and Tong G.Z. Interference of porcine reproductive and respiratory syndrome virus replication on MARC-145 cells using DNA-based short interfering RNAs. Antiviral. Res. 74 (2007) 83-91
14. Huang J., Jiang P., Li Y., Xu J., Jiang W., and Wang X. Inhibition of porcine reproductive and respiratory syndrome virus replication by short hairpin RNA in MARC-145 cells. Vet. Microbiol. 115 (2006) 302-310
15. Jacque J.M., Triques K., and Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 418 (2002) 435-438
16. Ji W.T., Chulu J.L., Lin F.L., Li S.K., Lee L.H., and Liu H.J. Suppression of protein expression of three avian reovirus S-class genome segments by RNA interference. Vet. Microbiol. 129 (2008) 252-261
17. Jia H., Ge X., Guo X., Yang H., Yu K., Chen Z., Chen Y., and Cha Z. Specific small interfering RNAs-mediated inhibition of replication of porcine encephalomyocarditis virus in BHK-21 cells. Antiviral. Res. (2008)
18. Lee C., Calvert J.G., Welch S.K., and Yoo D. A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity. Virology 331 (2005) 47-62
19. Li W.X., Li H., Lu R., Li F., Dus M., Atkinson P., Brydon E.W., Johnson K.L., Garcia-Sastre A., Ball L.A., Palese P., and Ding S.W. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 1350-1355
20. Li G., Huang J., Jiang P., Li Y., Jiang W., and Wang X. Suppression of porcine reproductive and respiratory syndrome virus replication in MARC-145 cells by shRNA targeting ORF1 region. Virus Genes 35 (2007) 673-679
21. Li Y., Wang X., Bo K., Wang X., Tang B., Yang B., Jiang W., and Jiang P. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Vet. J. 174 (2007) 577-584
22. Lu S., and Cullen B.R. Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis. J. Virol. 78 (2004) 12868-12876
23. Mateu E., and Diaz I. The challenge of PRRS immunology. Vet. J. (2007)
24. Mounir S., Mardassi H., and Dea S. Identification and characterization of the porcine reproductive and respiratory virus ORFs 7, 5 and 4 products. Adv. Exp. Med. Biol. 380 (1995) 317-320
25. Nelson E.A., Christopher-Hennings J., and Benfield D.A. Structural proteins of porcine reproductive and respiratory syndrome virus (PRRSV). Adv. Exp. Med. Biol. 380 (1995) 321-323
26. Nielsen H.S., Oleksiewicz M.B., Forsberg R., Stadejek T., Botner A., and Storgaard T. Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations. J. Gen. Virol. 82 (2001) 1263-1272
27. Rossow K.D. Porcine reproductive and respiratory syndrome. Vet. Pathol. 35 (1998) 1-20
28. Sanchez A.B., Perez M., Cornu T., and de la Torre J.C. RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virus. J. Virol. 79 (2005) 11071-11081
29. Snijder E.J., Wassenaar A.L., and Spaan W.J. Proteolytic processing of the replicase ORF1a protein of equine arteritis virus. J. Virol. 68 (1994) 5755-5764
30. Song E., Lee S.K., Wang J., Ince N., Ouyang N., Min J., Chen J., Shankar P., and Lieberman J. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9 (2003) 347-351
31. Tian, K., Yu, X., Zhao, T., Feng, Y., Cao, Z., Wang, C., Hu, Y., Chen, X., Hu, D., Tian, X., Liu, D., Zhang, S., Deng, X., Ding, Y., Yang, L., Zhang, Y., Xiao, H., Qiao, M., Wang, B., Hou, L., Wang, X., Yang, X., Kang, L., Sun, M., Jin, P., Wang, S., Kitamura, Y., Yan, J., Gao, G.F., 2007. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS ONE 2, e526.
32. Uprichard S.L., Boyd B., Althage A., and Chisari F.V. Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 773-778
33. van Dinten L.C., Wassenaar A.L., Gorbalenya A.E., Spaan W.J., and Snijder E.J. Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains. J. Virol. 70 (1996) 6625-6633
34. Wassenaar A.L., Spaan W.J., Gorbalenya A.E., and Snijder E.J. Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. J. Virol. 71 (1997) 9313-9322
35. Wissink E.H., van Wijk H.A., Kroese M.V., Weiland E., Meulenberg J.J., Rottier P.J., and van Rijn P.A. The major envelope protein, GP5, of a European porcine reproductive and respiratory syndrome virus contains a neutralization epitope in its N-terminal ectodomain. J. Gen. Virol. 84 (2003) 1535-1543
36. Wu W.H., Fang Y., Farwell R., Steffen-Bien M., Rowland R.R., Christopher-Hennings J., and Nelson E.A. A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology 287 (2001) 183-191
37. Zeman D., Neiger R., Yaeger M., Nelson E., Benfield D., Leslie-Steen P., Thomson J., Miskimins D., Daly R., and Minehart M. Laboratory investigation of PRRS virus infection in three swine herds. J. Vet. Diagn. Invest. 5 (1993) 522-528