Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

Biochemical and Biophysical Research Communications

Volumn 380, Issue 3, 2009, Pages 454-459

  Li, Xuerong ^a   Chen, Huiqing ^a   Bahamontes Rosa, Noemi ^b   Kun, Jurgen F J ^b   Traore, Boubacar ^c   Crompton, Peter D ^d   Chishti, Athar H ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF BAMAKO   (Mali)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Band 3; Erythrocyte; Intramembrane aspartyl protease; Malaria; Plasmodium falciparum; Presenilins; Signal peptide peptidase

Indexed keywords

ASPARTIC PROTEINASE; GAMMA SECRETASE; PRESENILIN 1; PROTOZOAL PROTEIN; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL INVASION; CELL SURVIVAL; CONTROLLED STUDY; GENE SILENCING; MALARIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CARBAMATES; DIPEPTIDES; DRUG DESIGN; ERYTHROCYTES; HUMANS; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RNA, SMALL INTERFERING;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 60849127534     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.083     Document Type: Article

References (17)

1. Snow R.W., Guerra C.A., Noor A.M., Myint H.Y., and Hay S.I. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434 (2005) 214-217
2. Blackman M.J. Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets. Curr. Drug Targets 1 (2000) 59-83
3. Rosenthal P.J. Proteases of malaria parasites: new targets for chemotherapy. Emerg. Infect. Dis. 4 (1998) 49-57
4. Rosenthal P.J. Hydrolysis of erythrocyte proteins by proteases of malaria parasites. Curr. Opin. Hematol. 9 (2002) 140-145
5. Hanspal M., Dua M., Takakuwa Y., Chishti A.H., and Mizuno A. Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development. Blood 100 (2002) 1048-1054
6. Baker R.P., Wijetilaka R., and Urban S. Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria. PLoS Pathog. 2 (2006) e113
7. O'Donnell R.A., Hackett F., Howell S.A., Treeck M., Struck N., Krnajski Z., Withers-Martinez C., Gilberger T.W., and Blackman M.J. Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite. J. Cell Biol. 174 (2006) 1023-1033
8. Brown M.S., Ye J., Rawson R.B., and Goldstein J.L. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100 (2000) 391-398
9. Urban S., Lee J.R., and Freeman M. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107 (2001) 173-182
10. Weihofen A., Binns K., Lemberg M.K., Ashman K., and Martoglio B. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296 (2002) 2215-2218
11. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., and Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398 (1999) 513-517
12. Li X., Chen H., Oo T.H., Daly T.M., Bergman L.W., Liu S.C., Chishti A.H., and Oh S.S. A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3. J. Biol. Chem. 279 (2004) 5765-5771
13. Li X., Chen H., Oh S.S., and Chishti A.H. A Presenilin-like protease associated with Plasmodium falciparum micronemes is involved in erythrocyte invasion. Mol. Biochem. Parasitol. 158 (2008) 22-31
14. Nyborg A.C., Ladd T.B., Jansen K., Kukar T., and Golde T.E. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. FASEB J. 20 (2006) 1671-1679
15. Crompton P.D., Traore B., Kayentao K., Doumbo S., Ongoiba A., Diakite S.A., Krause M.A., Doumtabe D., Kone Y., Weiss G., Huang C.Y., Doumbia S., Guindo A., Fairhurst R.M., Miller L.H., Pierce S.K., and Doumbo O.K. Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria. J. Infect. Dis. 198 (2008) 1265-1275
16. Arai M., Mitsuke H., Ikeda M., Xia J.X., Kikuchi T., Satake M., and Shimizu T. ConPred II: a consensus prediction method for obtaining transmembrane topology models with high reliability. Nucleic Acids Res. 32 (2004) W390-W393
17. Weihofen A., Lemberg M.K., Friedmann E., Rueeger H., Schmitz A., Paganetti P., Rovelli G., and Martoglio B. Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors. J. Biol. Chem. 278 (2003) 16528-16533