Monoclonal antibody 16D10 to the COOH-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues

Molecular Cancer Therapeutics

Volumn 8, Issue 2, 2009, Pages 282-291

  Benkoël, Liliane ^a   Bernard, Jean Paul ^a,b,d   Payan Defais, Marie José ^c   Crescence, Lydie ^a   Franceschi, Cécile ^a   Delmas, Mireille ^c   Ouaissi, Mehdi ^a,c   Sastre, Bernard ^c   Sahel, José ^d   Benoliel, Anne Marie ^e   Bongrand, Pierre ^e   Silvy, Françoise ^a   Gauthier, Laurent ^f   Romagné, François ^f   Lombardo, Dominique ^a,b   Mas, Eric ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^c TIMONE HOSPITAL   (France)

^d HÔPITAL DE LA CONCEPTION   (France)

^e INSERM   (France)

^f INNATE PHARMA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

16D10 ANTIGEN; BILE SALT DEPENDENT LIPASE; FETOACINAR PANCREAS PROTEIN; FETOPROTEIN; GEMCITABINE; GLYCOPEPTIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 16D10; MONOCLONAL ANTIBODY 8H8; TRIACYLGLYCEROL LIPASE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG TARGETING; FEMALE; HOMOGENATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR RECOGNITION; NUDE MOUSE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR XENOGRAFT;

EID: 60849115840     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0471     Document Type: Article

References (50)

1. Lombardo D. Bile salt-dependent lipase: its pathophysiological implications. Biochim Biophys Acta 2001;1533:1-28.
2. Lombardo D, Guy O. Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters. Biochim Biophys Acta 1980;611: 147-55.
3. Shamir R, Johnson WJ, Zolfaghari R, et al. Role of bile salt-dependent cholesteryl ester hydrolase in the uptake of micellar cholesterol by intestinal cells. Biochemistry 1995;34:6351-8.
4. Howles P, Carter C, Hui DY. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J Biol Chem 1996;271:7196-202.
5. Aubert-Jousset E, Garmy N, Sbarra V, et al. The combinatorial extension method reveals a sphingolipid binding domain on pancreatic bile salt-dependent lipase: role in secretion. Structure (Camb) 2004;12:1437-47.
6. Bruneau N, Lombardo D. Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase. J Biol Chem 1995;270:13524-33.
7. Bruneau N, Lechene de la Porte P, Sbarra V, et al. Association of bile salt-dependent lipase with membranes of human pancreatic microsomes. Eur J Biochem 1995;233:209-18.
8. Nganga A, Bruneau N, Sbarra V, et al. Control of the pancreatic bile salt-dependent lipase secretion by Grp94. Biochem J 2000;352:865-74.
9. Abouakil N, Mas E, Bruneau N, et al. Bile salt-dependent lipase biosynthesis in rat pancreatic AR 4-2 J cells. Essential requirement of N-linked oligosaccharide for secretion and expression of a fully active enzyme. J Biol Chem 1993;268:25755-63.
10. Bruneau N, Nganga A, Fisher EA, et al. O-glycosylation of C-terminal tandem-repeated sequences regulates the secretion of rat pancreatic bile salt-dependentlipase. JBiol Chem 1997;272:27353-61.
11. Vérine A, Le Petit-Thévenin J, Panicot-Dubois L, et al. Phosphorylation of human bile salt dependent lipase: identification of phosphorylation site and relation with secretion process. J Biol Chem 2000;276:12356-61.
12. Pasqualini E, Caillol N, Mas E, et al. Association of bile salt-dependent lipase with membranes of human pancreatic microsomes is under the control of ATP and phosphorylation. Biochem J 1997;327:527-37.
13. Pasqualini E, Caillol N, Valette A, et al. Phosphorylation of the rat pancreatic bile salt-dependent lipase by casein-kinase II is essential for secretion. Biochem J 2000;345:121-8.
14. Escribano MJ, Imperial S. Purification and molecular characterization of FAP, a feto-acinar protein associated with the differentiation of human pancreas. J Biol Chem 1989;264:21865-71.
15. Escribano MJ, Cordier J, Nap M, et al. Differentiation antigens in fetal human pancreas. Int J Cancer 1986;38:155-60.
16. Albers GHR, Escribano MJ, Gonzalez M, et al. Fetoacinar pancreatic protein in the developing human pancreas. Differentiation 1987;34:210-5.
17. Mas E, Abouakil N, Roudani S, et al. Human fetoacinar pancreatic protein: an oncofetal glycoform of the normally secreted pancreatic bile salt-dependentlipase. Biochem J 1993;269:609-15.
18. Pasqualini E, Caillol N, Panicot L, et al. Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase. J Biol Chem 1998;273:28208-18.
19. Miralles F, Langa F, Mazo A, et al. Retention of the fetoacinar pancreatic (FAP) protein to the endoplasmic reticulum of tumor cells. Eur J Cell Biol 1993;60:115-21.
20. Roudani S, Pasqualini E, Margotat A, et al. Expression of a 46 kDa protein in human pancreatic tumors and its possible relationship with the bile salt-dependent lipase. Eur J Cell Biol 1994;64:132-44.
21. Caillol N, Pasqualini E, Lloubes R, et al. Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. J Cell Biochem 2000;79:628-47.
22. Le Petit-Thévenin J, Verine A, Nganga A, et al. Impairment of bile salt-dependent lipase secretion in AR4-2J rat pancreatic cells induces its degradation by the proteasome. Biochim Biophys Acta 2001;1530:184-98.
23. Panicot-Dubois L, Aubert M, Franceschi C, et al. Monoclonal antibody 16D10 to the C-terminal domain of the feto-acinar pancreatic protein binds to membrane of human pancreatic tumoral SOJ-6 cells and inhibits the growth of tumor xenografts. Neoplasia 2004;6:713-24.
24. Mas E, Crotte C, Lecestre D, et al. The oncofetal J28 epitope involves fucosylated O-linked oligosaccharide structures of the fetoacinar pancreatic protein. Glycobiology 1997;7:745-55.
25. Panicot L, Mas E, Pasqualini E, et al. The formation of the oncofetal J28 glycotope involves core-2 β6-N-acetylglucosaminyltransferase and α3/4- fucosyltransferase activities. Glycobiology 1999;9:935-46.
26. Mas E, Pasqualini E, Caillol N, et al. The fucosyltransferase activities in human pancreatic tissues: comparative study between cancer tissues and established cell lines. Glycobiology1998;8:605-13.
27. Benkoel L, Dodero F, Hardwigsen J, et al. Effect of ischemia-reperfusion on bile canalicular F-actin microfilaments in hepatocytes of human liver allograft: image analysis by confocal laser scanning microscopy. Dig Dis Sci 2001;46:1663-7.
28. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
29. Kakimoto K, Takekoshi S, Miyajima K, Osamura RY. Hypothesis for the mechanism for heat-induced antigen retrieval occurring on fresh frozen sections without formalin-fixation in immunohistochemistry. J Mol Histol 2008;39:389-99.
30. Raeder H, Johansson S, Holm PI, et al. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet 2006;38:54-62.
31. Yang GY, Wagner TD, Fuss M, Thomas CR. Multimodality approaches for pancreatic cancer. CA Cancer J Clin 2005;55:352-67.
32. Ellenrieder V, Adler G, Gress TM. Invasion and metastasis in pancreatic cancer. Ann Oncol 1999;10:46-50.
33. Kobayashi T, Kawa S, Tokoo M, et al. Comparative study of CA-50 (time-resolved fluoroimmunoassay), Span-1, and CA 19-9 in the diagnosis of pancreatic cancer. Scand J Gastroenterol 1991;26:787-97.
34. Lan MS, Khorrani A, Kaufman B, et al. Molecular characterization of a mucin-type antigen associated with human pancreatic cancers: the Du-Pan 2 antigen. J Biol Chem 1987;262:12863-70.
35. Magnani JL, Steplewski Z, Koprowski H, et al. Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patient as mucin. Cancer Res 1983;43:5489-92.
36. Masson P, Palsson B, Andren-Sandberg A. Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status. Br J Cancer 1990;62:118-21.
37. Prat M, Medico E, Rossino P, et al. Biochemical and immunological properties of the human carcinoma-associated CAR-3 epitope defined by themonoclonal antibodyAR-3. Cancer Res1989;49:1415-21.
38. Ozkan H, Kaya M, Cengiz A. Comparison of tumor marker CA 242 with CA 19-9 and carcinoembryonic antigen (CEA) in pancreatic cancer. Hepatogastroenterology 2003;50:1669-74.
39. Narimatsu H, Iwasaki H, Nakayama F, et al. Lewis and secretor gene dosages affect CA 19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 1998;58:512-8.
40. Jiang JT, Wu CP, Deng HF, et al. Serum level of TSGF, CA242 and CA19-9 in pancreatic cancer. World J Gastroenterol 2004;10:1675-7.
41. Kim GE, Bae HI, Park HU, et al. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Gastroenterology 2002;123:1052-60.
42. Kim YS, Gum J, Brockhausen I. Mucin glycoproteins in neoplasia. Glycoconj J 1996;13:693-707.
43. Audie JP, Janin A, Porchet N, et al. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 1993;41:1479-85.
44. McCarthy DM, Maitra A, Argani P, et al. Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labelling increases accuracy in cytologically borderline cases. Appl Immunohistochem Mol Morphol 2003;11:238-43.
45. Mazo A, Fujii Y, Shimotake J, et al. Expression of fetoacinar pancreatic (FAP) protein in the pancreatic human tumor cell line BxPC-3. Pancreas 1991;6:37-45.
46. Imperial S, Escribano MJ. Concanavalin A variants of the fetoacinar pancreatic protein in the developing human pancreas and other biological sources. Biochim Biophys Acta 1988;967:25-33.
47. Takeda Y, Miralles F, Daher N, et al. Radioimmunolocalization of the monoclonal antibody J28 in early transformation stages in N-nitrosobis(2- hydroxypropyl)amine-induced pancreatic tumors in the Syrian golden hamster. J Cancer Res Clin Oncol 1992;118:377-85.
48. Walker RA. The significance of histological determination of HER-2 status in breast cancer. Breast 2000;9:130-3.
49. Xiong HQ, Rosenberg A, LoBuglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol 2004;22:2610-6.
50. Crane CH, Ellis LM, Abbruzzese JL, et al. Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecita-bine in locally advanced pancreatic cancer. J Clin Oncol 2006;24:1145-51.