Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1355-1362

  Virsodia, Vijay ^a   Manvar, Atul ^b   Upadhyay, Kuldip ^c   Loriya, Rajesh ^d   Karia, Denish ^b   Jaggi, Manu ^e   Singh, Anu ^e   Mukherjee, Rama ^e   Shaikh, Mushtaque S ^f   Coutinho, Evans C ^f   Shah, Anamik ^b  

^a Jubilant Organosys   (India)

^b SAURASHTRA UNIVERSITY   (India)

^c Torrent Research Centre   (India)

^d LUPIN LIMITED   (India)

^e DABUR RESEARCH FOUNDATION   (India)

^f BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

2 Indolinones; 3D QSAR; Anticancer activity; Colon cancer; SW620 cell line

Indexed keywords

1 (2,6 DICHLOROPHENYL) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 2 INDOLINONE; 1 (2,6 DICHLOROPHENYL) 3 ((2 CHLORO 6 METHYLQUINOLIN 3 YL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2 CHLORO 7,8 DIMETHYLQUINOLIN 3 YL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2 CHLOROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2 CHLOROQUINOLIN 3 YL)METHYENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2 NITROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2,4 DICHLOROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((2,6 DICHLOROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((3 BROMOBENZYLIDENE)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((3 PHENOXYPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((3,4 DIMETHOXYPHENYL)METHYENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((4 (DIMETHYLAMINO)PHENYL) METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((4 CHLOROPHENYL)METHYLENE)1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((4 FLUOROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((4 HYDROXYPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((4 METHOXYPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((FURAN 2 YL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((NAPHTHALEN 1 YL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 ((PHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 1 (2,6 DICHLOROPHENYL) 3 METHYLENE 1,3 DIHYDRO INDOL 2 ONE DERIVATIVE; 1 (2,6 DICHLOROPHENYL) 3((3 CHLOROPHENYL)METHYLENE) 1,3 DIHYDRO INDOL 2 ONE; 2 CHLORO N (2,6 DICHLOROPHENYL) N PHENYL ACETAMIDE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED;

EID: 60849109964     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.012     Document Type: Article

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