CD5 sweetens lymphocyte responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 5, 2009, Pages 1303-1304

  Lenz, Laurel L ^a  

^a DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; B LYMPHOCYTE RECEPTOR; BETA GLUCAN; CD5 ANTIGEN; CD6 ANTIGEN; DECTIN 1; ECHINOCANDIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOPEROXIDASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; SCAVENGER RECEPTOR; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 1; CELL SURFACE RECEPTOR;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ASPERGILLUS FUMIGATUS; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BACTERIAL CELL WALL; BACTERIAL INFECTION; CANDIDA ALBICANS; CELLULAR IMMUNITY; CRYPTOCOCCUS NEOFORMANS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FUNGAL CELL; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; LEUKOCYTOSIS; MOLECULAR RECOGNITION; MYCOSIS; NONHUMAN; NOTE; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SCHIZOSACCHAROMYCES POMBE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; CELL LINE; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTIGENS, CD5; CELL LINE; HUMANS; LYMPHOCYTES; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 60849104138     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812579106     Document Type: Note

References (15)

1. Vera J, et al. (2009) The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. Proc Natl Acad Sci USA 106:1506-1511.
2. Sarrias MR, et al. (2007) CD6 binds to pathogen- associated molecular patterns and protects from LPS- induced septic shock. Proc Natl Acad Sci USA 104:11724-11729.
3. Berland R, Wortis HH (2002) Origins and functions of B-1 cells with notes on the role of CD5. Annu Rev Immunol 20:253-300.
4. Tarakhovsky A, et al. (1995) A role for CD5 in TCR- mediated signal transduction and thymocyte selection. Science 269:535-537.
5. Hippen KL, Tze LE, Behrens TW (2000) CD5 maintains tolerance in anergic B cells. J Exp Med 191:883-890.
6. Brossard C, Semichon M, Trautmann A, Bismuth G (2003) CD5 inhibits signaling at the immunological synapse without impairing its formation. J Immunol 170:4623-4629.
7. Gimferrer I, et al. (2003) The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. J Biol Chem 278:8564-8571.
8. Van de Velde H, von Hoegen I, Luo W, Parnes JR, Thielemans K (1991) The B-cell surface protein CD72/ Lyb-2 is the ligand for CD5. Nature 351:662-665.
9. Perez-Villar JJ, et al. (1999) CD5 negatively regulates the T cellantigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol 19:2903-2912.
10. Gary-Gouy H, et al. (2002) Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production. Blood 100:4537-4543.
11. Dillon S, et al. (2006) Yeastzymosan,astimulusforTLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest 116:916-928.
12. Tsoni SV, Brown GD (2008) β-Glucans and dectin-1. Ann NY Acad Sci 1143:45-60.
13. Gantner BN, Simmons RM, Underhill DM (2005) Dec- tin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 24:1277-1286.
14. Hohl TM, Feldmesser M, Perlin DS, Pamer EG (2008) Caspofungin modulates inflammatory responsesto Aspergillus fumigatus through stage-specific effects on fungal β-glucan exposure. J Infect Dis 198:176-185.
15. Humann J, Lenz LL (2008) Bacterial peptidoglycan- degrading enzymes and their impact on host muropep- tide detection. J Innate Immun, 10.1159/000181181.