-
1
-
-
20044386299
-
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA-4Ig with potent immunosuppressive properties
-
Larsen C, Pearson T, Adams A, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA-4Ig with potent immunosuppressive properties. Am J Transplant 2005; 5:443-453.
-
(2005)
Am J Transplant
, vol.5
, pp. 443-453
-
-
Larsen, C.1
Pearson, T.2
Adams, A.3
-
2
-
-
38949173232
-
Costimulation blockade in autoimmunity and transplantation
-
Vincenti F. Costimulation blockade in autoimmunity and transplantation. J Allergy Clin Immunol 2008; 121:299-306.
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 299-306
-
-
Vincenti, F.1
-
3
-
-
23944502334
-
Costimulation blockade with belatacept in renal transplantation
-
Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353:770-781.
-
(2005)
N Engl J Med
, vol.353
, pp. 770-781
-
-
Vincenti, F.1
Larsen, C.2
Durrbach, A.3
-
4
-
-
34247580749
-
Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with belatacept mediated CD28-CD80/86 blockade
-
Chavez H, Beaudreuil S, Abbed K, et al. Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with belatacept mediated CD28-CD80/86 blockade. Transpl Immunol 2007; 17:243-248.
-
(2007)
Transpl Immunol
, vol.17
, pp. 243-248
-
-
Chavez, H.1
Beaudreuil, S.2
Abbed, K.3
-
5
-
-
23944491219
-
Immunosuppression- the promise of specificity
-
Ingelfinge JR, Schwartz RS. Immunosuppression- the promise of specificity. N Engl J Med 2005; 353:836-839.
-
(2005)
N Engl J Med
, vol.353
, pp. 836-839
-
-
Ingelfinge, J.R.1
Schwartz, R.S.2
-
6
-
-
33645890847
-
New approaches to prevent transplant rejection: Costimulation blockers anti-CD40L and CTLA4Ig
-
Pree I, Wekerle T. New approaches to prevent transplant rejection: costimulation blockers anti-CD40L and CTLA4Ig. Drug Discov Today Ther Strateg 2006; 3:41-47.
-
(2006)
Drug Discov Today Ther Strateg
, vol.3
, pp. 41-47
-
-
Pree, I.1
Wekerle, T.2
-
7
-
-
34249696032
-
Immunosuppression on the horizon
-
Eisen HJ. Immunosuppression on the horizon. Heart Fail Clin 2007; 3:43-49.
-
(2007)
Heart Fail Clin
, vol.3
, pp. 43-49
-
-
Eisen, H.J.1
-
8
-
-
34047186008
-
T cell costimulation: A rational target in the therapeutic armamentarium for autoimmune diseases and transplantation
-
Vincenti F, Luggen M. T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation. Annu Rev Med 2007; 58:347-358.
-
(2007)
Annu Rev Med
, vol.58
, pp. 347-358
-
-
Vincenti, F.1
Luggen, M.2
-
9
-
-
33745257254
-
A new look at blockade of T-cell costimulation: A therapeutic strategy for long term maintenance immunosuppression
-
Larsen CP, Knechtle SJ, Adams A, et al. A new look at blockade of T-cell costimulation: a therapeutic strategy for long term maintenance immunosuppression. Am J Transplant 2006; 6 (5 Pt 1):876-883.
-
(2006)
Am J Transplant
, vol.6
, Issue.5 PART 1
, pp. 876-883
-
-
Larsen, C.P.1
Knechtle, S.J.2
Adams, A.3
-
10
-
-
34447542808
-
Costimulation blockade - what will the future bring?
-
Vincenti F. Costimulation blockade - what will the future bring? Nephrol Dial Transplant 2007; 22:1293-1296.
-
(2007)
Nephrol Dial Transplant
, vol.22
, pp. 1293-1296
-
-
Vincenti, F.1
-
11
-
-
34248159578
-
New treatments for acute humoral rejection of kidney allografts
-
Venetz JP, Pascual M. New treatments for acute humoral rejection of kidney allografts. Expert Opin Investig Drugs 2007; 16:625-633.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 625-633
-
-
Venetz, J.P.1
Pascual, M.2
-
12
-
-
34247275965
-
-
Créput C, Durrbach A, Deroure B, Charpentier B. New therapeutic targets for antibodies and recombinant proteins in organ transplantation. CurrOpin Mol Ther 2007; 9:153-159.
-
Créput C, Durrbach A, Deroure B, Charpentier B. New therapeutic targets for antibodies and recombinant proteins in organ transplantation. CurrOpin Mol Ther 2007; 9:153-159.
-
-
-
-
13
-
-
34347237615
-
Novel immunosuppression: Small molecules and biologics
-
Yabu JM, Vincenti F. Novel immunosuppression: small molecules and biologics. Semin Nephrol 2007; 27:479-486.
-
(2007)
Semin Nephrol
, vol.27
, pp. 479-486
-
-
Yabu, J.M.1
Vincenti, F.2
-
14
-
-
31644437625
-
Protein therapies and antiproliferatives: A new paradigm in immunosuppression
-
Vincenti F. Protein therapies and antiproliferatives: a new paradigm in immunosuppression. Transplant Rev 2005; 19:179-185.
-
(2005)
Transplant Rev
, vol.19
, pp. 179-185
-
-
Vincenti, F.1
-
15
-
-
28044462615
-
Enhanced immunosuppression induced by targeted mutation of cytotoxic T lymphocyte antigen 4-immunoglobulin
-
Kokko KE, Newell KA, Pearson TC, Larsen CP. Enhanced immunosuppression induced by targeted mutation of cytotoxic T lymphocyte antigen 4-immunoglobulin. Curr Opin Org Transplant 2005; 10:265-269.
-
(2005)
Curr Opin Org Transplant
, vol.10
, pp. 265-269
-
-
Kokko, K.E.1
Newell, K.A.2
Pearson, T.C.3
Larsen, C.P.4
-
16
-
-
35048869532
-
Induction therapy in pediatric renal transplant recipients: An overview
-
Moudgil A. Induction therapy in pediatric renal transplant recipients: an overview. Pediatr Drugs 2007; 9:323-341.
-
(2007)
Pediatr Drugs
, vol.9
, pp. 323-341
-
-
Moudgil, A.1
-
17
-
-
0028675006
-
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
-
Linsley PS, Greene JL, Brady W, et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1:793-801.
-
(1994)
Immunity
, vol.1
, pp. 793-801
-
-
Linsley, P.S.1
Greene, J.L.2
Brady, W.3
-
18
-
-
30544441366
-
Belatacept: Treatment of transplant rejection
-
McIntyre JA, Fernande D. Belatacept: treatment of transplant rejection. Drugs Future 2005; 30:873-876.
-
(2005)
Drugs Future
, vol.30
, pp. 873-876
-
-
McIntyre, J.A.1
Fernande, D.2
-
19
-
-
23344434758
-
Technology evaluation: Belatacept, Bristol-Myers Squibb
-
Vanhove B, Soulillou JP. Technology evaluation: belatacept, Bristol-Myers Squibb. Curr Opin Mol Ther 2005; 7:384-393.
-
(2005)
Curr Opin Mol Ther
, vol.7
, pp. 384-393
-
-
Vanhove, B.1
Soulillou, J.P.2
-
20
-
-
67649118864
-
Belatacept does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity
-
Davis PM, Nadler S, Suchard S. Belatacept does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity. Am J Transplant 2008; 8 (Suppl 2):619.
-
(2008)
Am J Transplant
, vol.8
, Issue.SUPPL. 2
, pp. 619
-
-
Davis, P.M.1
Nadler, S.2
Suchard, S.3
-
22
-
-
33644826737
-
Does belatacept provide equivalent suppression of acute renal transplant rejection to ciclosporin? Nat Clin Pract
-
SayeghM,ChrandrakerA. Does belatacept provide equivalent suppression of acute renal transplant rejection to ciclosporin? Nat Clin Pract Nephrol 2006; 2:134-135.
-
(2006)
Nephrol
, vol.2
, pp. 134-135
-
-
Sayegh, M.1
Chrandraker, A.2
-
23
-
-
67649974418
-
Current use and future trends in induction therapy
-
Vincenti F. Current use and future trends in induction therapy. Saudi J Kidney Dis Transpl 2005; 16:506-513.
-
(2005)
Saudi J Kidney Dis Transpl
, vol.16
, pp. 506-513
-
-
Vincenti, F.1
-
24
-
-
33746547309
-
Immunosuppression: Today, tomorrow, and withdrawal
-
Hirose R, Vincenti F. Immunosuppression: today, tomorrow, and withdrawal. Semin Liver Dis 2006; 26:201-210.
-
(2006)
Semin Liver Dis
, vol.26
, pp. 201-210
-
-
Hirose, R.1
Vincenti, F.2
-
25
-
-
33745235090
-
Transplant tolerance in nonhuman primates: Progress, current challenges and unmet needs
-
Kean LS, Gangappa S, Pearson TC, Larsen CP. Transplant tolerance in nonhuman primates: progress, current challenges and unmet needs. Am J Transplant 2006; 6 (5 Pt 1):884-893.
-
(2006)
Am J Transplant
, vol.6
, Issue.5 PART 1
, pp. 884-893
-
-
Kean, L.S.1
Gangappa, S.2
Pearson, T.C.3
Larsen, C.P.4
-
26
-
-
38149028526
-
Belatacept and basilix-imab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity
-
Emamaullee JA, Merani S, Larsen CP, Shapiro AMJ. Belatacept and basilix-imab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity. Transplantation 2008; 85:118-124.
-
(2008)
Transplantation
, vol.85
, pp. 118-124
-
-
Emamaullee, J.A.1
Merani, S.2
Larsen, C.P.3
Shapiro, A.M.J.4
-
27
-
-
0036061575
-
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogenic islets in nonhuman primates
-
Adams AB, Shirasugi Nozumu, Durham MM, et al. Calcineurin inhibitor-free CD28 blockade-based protocol protects allogenic islets in nonhuman primates. Diabetes 2002; 51: 265-270.
-
(2002)
Diabetes
, vol.51
, pp. 265-270
-
-
Adams, A.B.1
Shirasugi Nozumu, D.M.M.2
-
28
-
-
12644262358
-
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
-
Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997; 94:8789-8794.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 8789-8794
-
-
Kirk, A.D.1
Harlan, D.M.2
Armstrong, N.N.3
-
29
-
-
0000203537
-
Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation
-
Kirk A, Knechtle SJ, Sollinger HW, et al. Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation. Am J Transplant 2001; 1 (Suppl 1):191.
-
(2001)
Am J Transplant
, vol.1
, Issue.SUPPL. 1
, pp. 191
-
-
Kirk, A.1
Knechtle, S.J.2
Sollinger, H.W.3
-
30
-
-
19944412462
-
-
AdamsAB, ShirasugiN, Jones TR, et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174:542-550.
-
AdamsAB, ShirasugiN, Jones TR, et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174:542-550.
-
-
-
-
31
-
-
67649909304
-
Belatacept modulates T-cell proliferation and effector function independent of IDO induction
-
Davis PM, Nadler S, Suchard S. Belatacept modulates T-cell proliferation and effector function independent of IDO induction. Am J Transplant 2008; 8 (Suppl 2):620.
-
(2008)
Am J Transplant
, vol.8
, Issue.SUPPL. 2
, pp. 620
-
-
Davis, P.M.1
Nadler, S.2
Suchard, S.3
-
32
-
-
53549112519
-
-
Löb S, Königsrainer A. Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? Langenbecks Arch Surg 2007. 10.1007/ s00423-007-0245-7.
-
Löb S, Königsrainer A. Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? Langenbecks Arch Surg 2007. 10.1007/ s00423-007-0245-7.
-
-
-
-
33
-
-
67649983733
-
Effect of belatacept on circulating and intragraft regulatory T cells in kidney transplant patients
-
Yabu JL, Liu W, Putnam A, et al. Effect of belatacept on circulating and intragraft regulatory T cells in kidney transplant patients. Am J Transplant 2008; 8 (Suppl 2):282.
-
(2008)
Am J Transplant
, vol.8
, Issue.SUPPL. 2
, pp. 282
-
-
Yabu, J.L.1
Liu, W.2
Putnam, A.3
-
34
-
-
67649977439
-
The importance of persisting allostimulation for the maintenance of tolerance and regulatory T-cells
-
Takahasi K, Kawai M, Soma T, et al. The importance of persisting allostimulation for the maintenance of tolerance and regulatory T-cells. Am J Transplant 2008; 8 (Suppl 2):407.
-
(2008)
Am J Transplant
, vol.8
, Issue.SUPPL. 2
, pp. 407
-
-
Takahasi, K.1
Kawai, M.2
Soma, T.3
-
35
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
Suntharalingam G, Perry M, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006; 355:1018-1028.
-
(2006)
N Engl J Med
, vol.355
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.2
Ward, S.3
|